5. CRETIA: 50 substance are there
Synthesized by pre-synaptic neurons with the help
of synthesizing enzyme and stored in vesicles at
axon terminal.
Stimulation of nerve cause release of transmitters.
Travels between pre to post-synpatic membrane.
Associated with an enzyme system(inactivation).
Mimic the effects of nerve stimulation outside.
Drugs which modifies nerve stimulation also
modifies transmitter action the similar way.
7. ACTION OF NEUROTRANSMITTERS
general characteristics
Neurotransmitter travels pre post synaptic
Receptors associated with Ion channels and
enzyme(second messenger)
Acts in milliseconds
Activate both pre and post synaptic receptors.
More transmitter interact both pre and post
synaptically (Sp Rec & sp effects)
12. Acetycholine:
SYNTHESIS:
• Vasodilation,
• cardiac inhibition,
• GI peristalsis;
• control of thought, mood, sleep, muscles, bladder,
sweat glands
13. SYNTESIS
Catecholamines:
Dopamine:
Control of movements(parkinsonism)
Induction of vomiting
Inhibition of prolactin secretion
Stimulation of GnRH
Schizophrenia