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Neurotransmitters and its mechanism of action

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Neurotransmitters and its mechanism of action

  1. 1. Neurotransmitters and its mechanism of action Presented by R.Parthasarathy
  2. 2. INTRODUCTION: What is neurotransmitter Criteria General characteristics features Classification biochemical physiological Mechanism of action of individual chemical
  3. 3. ANATOMY OF NERVE: Postsynaptic: Muscle  Contraction Neuron  Action potential Glands  Secretion
  4. 4. DEFINITION: Neurotransmitters are the chemical substances which are responsible for transmission of an impulse through a synapse. Schematic diagram of synapse
  5. 5. CRETIA: 50 substance are there  Synthesized by pre-synaptic neurons with the help of synthesizing enzyme and stored in vesicles at axon terminal.  Stimulation of nerve cause release of transmitters.  Travels between pre to post-synpatic membrane.  Associated with an enzyme system(inactivation).  Mimic the effects of nerve stimulation outside.  Drugs which modifies nerve stimulation also modifies transmitter action the similar way.
  6. 6. Neuromediators or neurohormones: Neuromodulators: Neuromodulators: Eg: VIP,somatostatin,ckk,substance P etc
  7. 7. ACTION OF NEUROTRANSMITTERS general characteristics Neurotransmitter travels pre  post synaptic Receptors associated with Ion channels and enzyme(second messenger) Acts in milliseconds Activate both pre and post synaptic receptors. More transmitter interact both pre and post synaptically (Sp Rec & sp effects)
  8. 8. CLASSIFICATION: BIOCHEMICALLY
  9. 9. PYSIOLOGICALLY EXCITATORY INHIBITORY Eg:Acetylcholine GABA Aspartate Glycine Dopamine Histamine Norepinephrine Epinephrine Glutamate Serotonin
  10. 10. Excitatory neurotransmitters:
  11. 11. Inhibitory neurotransmitters:
  12. 12. Acetycholine: SYNTHESIS: • Vasodilation, • cardiac inhibition, • GI peristalsis; • control of thought, mood, sleep, muscles, bladder, sweat glands
  13. 13. SYNTESIS Catecholamines: Dopamine: Control of movements(parkinsonism) Induction of vomiting Inhibition of prolactin secretion Stimulation of GnRH Schizophrenia
  14. 14. Serotonin: SYNTHESIS: FUNCTIONS: Regulation Carbohydrate intake & Hypthalamic releasing hormone Pain inhibition Hallucinations and 5HT Depression of mood
  15. 15. Histamine: SYNTHESIS:
  16. 16. Amino acid: SYNTHESIS:
  17. 17. OVERVIEW .
  18. 18. Neuropeptide transmitters:
  19. 19. General mechanism of action
  20. 20. Acetylcholine esterase
  21. 21. Thank you

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