Platelet rich fibrin
•Transferir como PPT, PDF•
3 gostaram•2,678 visualizações
presentation by Dr Ramesh R
Recomendados
Mais conteúdo relacionado
Mais procurados
Mais procurados (20)
Destaque
Destaque (15)
Mais de Dr Ramesh R
Mais de Dr Ramesh R (18)
Último
Último (20)
Platelet rich fibrin
- 1. GDC Platelet Rich Plasma Dr Ramesh R Kannur dental College
- 2. GDC Definition • PRP (Pletelet rich plasma) :concentrated source of autologous PLTs. • Platelet concentrate • APG(Autologous platelet gel) • Buffy coat
- 3. GDC Α-granules • At least 7 different growth factors that stimulate bone & soft tissue healing • PDGF • TGF • VEGF • EGF
- 4. GDC Α-granules • Do not contain insulin-like growth factors nor BMP • Adhesion molecule fibronectin vitronectin fibrin
- 5. GDC The role of PLT in wound healing • Injury • PLT activation • Within 10 min, granule migrate to the cell membrane surface and secrete growth factors ( inactive)
- 7. GDC 7 days later • PLT exhausted after 7 days • Macrophage by low oxygen tension, acidity, lactate concentration • Secrete same growth factors • Activated until it is down regulated by the restoration of normal oxygen tension
- 8. GDC Day 3rd
- 9. GDC 17days • Graft is completely permeated by new capillaries • Initial osteoid formation • Osteoclast resorb osteoid and BMP released • New bone formation and maturation
- 10. GDC Days 14
- 11. GDC Growth factors in PLT
- 12. GDC PDGF(pletelet-derived growth factors) • PDGF • Promoting angiogenesis, re-epithelization,formation of granulation tissue • Chemotaxis for mesenchymal cell,monocyte,neutrophiles
- 13. GDC TGF(transforming growth factor) • TGF • Stimulate cell replication similar to PDGF • Stimulate matrix production and guide differentiation towards cartilage or bone
- 14. GDC • Most potent multifuctional regulator of bone cell metabolism
- 15. GDC VEGF(vascular endothelial growth factor) • Effects on endothelial cells
- 16. GDC EGF(epithelial growth facator) • Effect limited on the basal cells of skin and mucus membrane
- 17. GDC The mechanism of growth factor effects on cells Inactive state
- 19. GDC Clinical effects of PRP on bone regeneration Platelet RBC Normal blood PRP
- 20. GDC • 4~7 times above a concentration of platelets than peripheral blood plates level • Bone mineral density 1.6~2,2 times increased • Rapid bone formation & earlier maturation.
- 21. GDC Trabecular area Native mandible Autogenous BG PRP
- 22. GDC Clinical effects of PRP on soft tissue healing • Split thickness skin graft
- 23. GDC 6 days Thrombin side : 5% epithelization 95% granulation tissue PRP side ; 95% epithelization 5% granulation tissue
- 24. GDC 6 months Thrombin side scarring hypo and hyper- pigmentation area PRP side less scarring Much less pigmentation change
- 25. GDC Patient discomfort • Patient discomfort decrease
- 27. GDC 6days ↔ ↔
- 28. GDC 1 months
- 29. GDC Mechanism • Growth factors contained PRP stimulated complete revascularization earlier and more complete • Early epithelial covering of exposed granulation tissue and C.T, the development of dermis is the mechanism that reduced scarring and a maximum regeneration of normal skin pigmentation
- 30. GDC Bovine thrombin issue • Bovine thrombin + CaCl2 clot initiator to activate PRP • CJD mad cow disease • Postop bleeding 100mg/ml of bovine factor
- 31. GDC Contraindications • Pre-existing coagulation defect : thrombocytopenia, hypofibrinogen • Hypersensitivity to bovine thrombin
- 32. GDC Clinical Application Chronic & Non-Healing Wounds Ears, Nose and Throat Surgery Gerneral Surgery Neurosurgery Ophthalmology Oral Surgery, Peridontal, Dental Implant Orthopedic Surgery Reconstructive / Plastic Surgery Urology