1. Airborne Pathogens Can Induce Mad Cow Disease, New Findings Suggest AND Unfolding Pathogenesis in Parkinson’s: Breakthrough Suggests Damaged Proteins Travel Between Cells Mateo Zuluaga Gómez Medicine Student UPB Medellín-Colombia

2. FOLDING

3. FOLDING

4. INTRODUCTION PRION PROTEIN DNA REPLICATION Parkinson Disease affects the Central Neural System

5. Airborne Pathogens Can Induce Mad Cow Disease, New Findings Suggest Science Daily January 14,2011

6. Airborne Pathogens Can Induce Mad Cow Disease, New Findings Suggest Science Daily January 14,2011 PRION IS AN INFECTIOUS AGENT THAT COULD AFFECT THE HUMAN BODY ON DIFFERENT SITES PRION COULD REPLICATE HIS DNA INFORMATION

7. Airborne Pathogens Can Induce Mad Cow Disease, New Findings Suggest Science Daily January 14,2011 PRION COULD BE TRANSPORTED BY THE FOOD INGESTINS AND SURGICAL ELEMENTS PRION COULD BE TRANSPORTED BY THE AIR NEW INVESTIGATION

8. Airborne Pathogens Can Induce Mad Cow Disease, New Findings Suggest Science Daily January 14,2011 The investigators made tests with immunosupresed and immunocompetents mices to determine if they would be vulnerable to the air transmission prions Prions can induce mad cow disease

9. OBSERVATION

10. Unfolding Pathogenesis in Parkinson’s: Break through Suggests Damaged Proteins Travel Between Cells Science Daily January 26,2011

11. Unfolding Pathogenesis in Parkinson’s: Break through Suggests Damaged Proteins Travel Between Cells Science Daily January 26,2011 Parkinson is a degenerative disease that affects the neurons of the Substancia Nigra. It produces cognitive alteration , emotional alteration and loss of the autonomous functionality

12. Unfolding Pathogenesis in Parkinson’s: Break through Suggests Damaged Proteins Travel Between Cells Science Daily January 26,2011 The investigation found a misfolding of the protein alpha-synuclein (Implicated in Parkinson´s disease) Alpha-synuclein

13. Unfolding Pathogenesis in Parkinson’s: Break through Suggests Damaged Proteins Travel Between Cells Science Daily January 26,2011 Protein Alpha-synuclein could be transfered from one cell to other one, and also it can aggregate in cell receptors Cell Receptor

14. OBSERVATION

15. MEDICAL UTILITY The investigations about prions must be principal topics in health care and also it may has a real value, to find enigmatic solutions to problems that this pathogenic agent can develop as the BSE

16. MEDICAL UTILITY The parkinson´s disease is a great topic of world interest that must go stopping due to the advance in the investigations, it could have gone away distinguishing information that has not been reported about the disease and the manner for helping the patients who suffer it

17. MEDICAL UTILITY When the science knows the mechanism of the alpha sinucleina protein the world could work in different topics, for example the physiopatology of parkinson and the treatment indicated to diminish the symptoms of the patient

18. MEDICAL UTILITY The investigation is an important field in the medicine because it allows to quantify and to qualify variables and also it allows other actions for reaching the medicine

19. BIBLIOGRAPHY · MARTINEZ S, Lina María. Biología molecular. 3. ed. Medellín: UPB. Fac. de Medicina. · Unfolding Pathogenesis in Parkinson’s: Breakthrough Suggests Damaged Proteins Travel Between Cells. Science Daily. January 26, 2011 Airborne Pathogens Can Induce Mad Cow Disease, New Findings Suggest. Science Daily. January 14, 2011

20. THANK YOU