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Just-in-time assembly: Transcriptional and post-translational cell-cycle regulation of protein complexes
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Lars Juhl Jensen
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Centre for Computational and Systems Biology (CoSBi), Trento, Italy, January 12, 2010.
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Just-in-time assembly: Transcriptional and post-translational cell-cycle regulation of protein complexes
1.
Just-in-time assembly Transcriptional
and post-translational cell-cycle regulation of protein complexes Lars Juhl Jensen
2.
3.
sequence analysis
4.
Jensen & Knudsen,
Bioinformatics , 2000
5.
Jensen, Gupta et
al., Journal of Molecular Biology , 2002
6.
7.
data integration
8.
Jensen, Kuhn et
al., Nucleic Acids Research , 2009
9.
Jensen & Bork,
Science , 2008
10.
Campillos, Kuhn et
al., Science , 2008
11.
12.
signaling networks
13.
Linding, Jensen, Ostheimer
et al., Cell , 2007
14.
text mining
15.
Pafilis, O’Donoghue, Jensen
et al., Nature Biotechnology , 2009
16.
the cell cycle
17.
complex process
18.
one cell
19.
two cells
20.
21.
regulation
22.
gene expression
23.
protein complexes
24.
phosphorylation
25.
targeted degradation
26.
gene expression
27.
cell cultures
28.
S. cerevisiae
29.
30.
synchronization
31.
microarrays
32.
33.
time courses
34.
Gauthier et al.,
Nucleic Acids Research , 2007
35.
cycling genes
36.
renormalization
37.
reanalysis
38.
new scoring scheme
39.
benchmarking
40.
Gauthier et al.,
Nucleic Acids Research , 2007
41.
protein complexes
42.
interaction data
43.
temporal network
44.
de Lichtenberg, Jensen
et al., Science , 2005
45.
de Lichtenberg, Jensen
et al., Science , 2005
46.
hypothesis
47.
just-in-time assembly
48.
de Lichtenberg, Jensen
et al., Cell Cycle , 2007
49.
how can we
test it?
50.
evolutionary flexibility
51.
reanalysis
52.
microarray time courses
53.
S. pombe
54.
H. sapiens
55.
A. thaliana
56.
cycling genes
57.
orthologous genes
58.
Jensen, Jensen, de
Lichtenberg et al., Nature , 2006
59.
protein complexes
60.
Jensen, Jensen, de
Lichtenberg et al., Nature , 2006
61.
phosphorylation
62.
63.
CDK substrate
64.
low-throughput data
65.
high-throughput data
66.
NetPhosK
67.
correlation
68.
Jensen, Jensen, de
Lichtenberg et al., Nature , 2006
69.
Jensen, Jensen, de
Lichtenberg et al., Nature , 2006
70.
correlated changes
71.
Jensen, Jensen, de
Lichtenberg et al., Nature , 2006
72.
Jensen, Jensen, de
Lichtenberg et al., Nature , 2006
73.
co-evolution
74.
transcriptional regulation
75.
posttranslational regulation
76.
phosphoproteomics
77.
SILAC study of
HeLa cells
78.
multi-block strategy
79.
Olsen, Vermeulen et
al., Science Signaling , 2010
80.
cycling proteins
81.
Olsen, Vermeulen et
al., Science Signaling , 2010
82.
regulation of kinases
83.
Olsen, Vermeulen et
al., Science Signaling , 2010
84.
regulation by kinases
85.
Olsen, Vermeulen et
al., Science Signaling , 2010
86.
evolution of cycles
87.
other periodic processes
88.
microarray time courses
89.
ultradian cycle
90.
S. cerevisiae
91.
Trachana, Jensen &
Bork, EMBO Reports , 2010
92.
diurnal cycle
93.
A. thaliana
94.
Trachana, Jensen &
Bork, EMBO Reports , 2010
95.
mammals
96.
Trachana, Jensen &
Bork, EMBO Reports , 2010
97.
paralogous genes
98.
same cellular functions
99.
different periodic processes
100.
three independent lineages
101.
summary
102.
reanalysis
103.
integration
104.
high-throughput data
105.
biological discoveries
106.
107.
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