Biology 280S - Advanced in DNA Nanomedicine

DNA Nanotechnology ,[object Object],[object Object],[object Object],[object Object],In Cancer Therapeutics

Outline ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Cancer ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Cancer: Barriers to Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Standing Order: Diagnostics & Therapeutics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],In situ : Breast Cancer tissue 400x

State of the Art: Cancer Nanotechnology Detection Treatment DNA Microarrays Bio “Finger” Nanoparticles Nanoparticles Earlier detection Better Targeting Imaging Receptor Mediated Lab on Chip Radiation Activated Gene based Metabolic based Tissue Engineering Cells GF scaffolding

Cancer Nanotechnology: Detection ,[object Object]

Cancer Nanotechnology: Treatment

Cancer Nanotechnology: Treatment continued . . .

Movie: National Cancer Institute ,[object Object],[object Object]

Outline: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

DNA Nanotechnology: Properties ,[object Object],[object Object],[object Object],State Dependent: f(x):  Energy  Environment  H =  E + P  V

Designed DNA molecules: Principles and Applications of Nanotechnology Condon, Anne Nature Reviews (2006) 7 : 565-575

An Autonomous Molecular Computer for Logical Control of Gene Expression Yaakov Benenson, Binyamin Gil, Uri Ben-Dor, Rivka Adar & Ehud Shapiro Nature (2004) 429 : 423-429 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

DNA-folding Pathways and their uses continued…

The Shape of Things to come ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Next Generation Gene Therapy: IL-2 MHC-I/II Bool statement IFN-  IFN-  IFN-  Constitutive Promotor Viral/Bacterial Ag Bool statement Constitutive Promotor Apoptosis Array Immune System Mobilization coupled with Antigen Presentation: Self-Destruct Program: Anti-cyclin Array Bool statement Constitutive Promotor Cell Cycle Downregulation (Growth): Nuclear Reprogramming (Repair): p53 Bool statement Constitutive Promotor Rb Reporter Reporter Reporter Reporter

Conclusion: What does this mean? ,[object Object],[object Object],[object Object],[object Object],[object Object]

References: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Biology 280S - Advanced in DNA Nanomedicine

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Biology 280S - Advanced in DNA Nanomedicine