The document describes the Healthcare Institute for Neuro-Recovery and Innovation (HINRI) Labs, which aims to advance patient-centered research, rehabilitation, restoration, and recovery from neurological impairments. HINRI Labs will create translational laboratories in Atlanta, Palo Alto, and Boston to link scientific innovation with clinical application. The goals are to speed research into practice, develop coordinated patient care, engage various stakeholders, and establish best practices. Areas of focus include spinal cord injury, traumatic brain injury, stroke, and neurological disorders.

1. Healthcare Institute for Neuro-Recovery and Innovation HINRI Labs © 2009 “ Turning knowledge into practice to transform lives.” Translational

8. Translational Research HINRI Labs © 2008 Atlanta* Boston* Palo Alto* HINRI LABS Finding Patient Centered Solutions Restoration Rehabilitation Recovery * Academia, Science, Medicine, Business, Philanthropy, and Public Policy

9. Translational Rehabilitation HINRI Labs HINRI Labs HINRI Labs Activity-Based Electrophysiology Patients Payors Nutrition/Supplements Mental, Spiritual Emotional Health Locomat & Armin Tissue Regeneration Manual Therapy Medical Monitoring Patient Centered Best Practices Improved Functionality Optimum Capabilities Hyperbaric Chamber Collaboration Traditional Rehab Non-Traditional Rehab Assistive Technology Clinical Trials Clinical Practice Academia, Business HINRI Labs © 2008

10. Translational Restoration HINRI Labs © 2008 Basic Research “ P of P” Research Clinical Research Clinical Practice University Partners HINRI Labs Shepherd Center Trauma Centers “ Proof of Principle” Research – Does the basic science & new ideas hold true for human patients? HINRI Translational Lab’s patient-centered clinical trial platform will foster collaboration between universities and clinical research centers.

11. Translational Recovery HINRI Labs © 2008 Medication Therapy Physical Health Nutrition Socialization Readiness for Employment Education Spirituality Leisure Activities Family and Friends Patient Centered Goals Normality Functionality Fulfillment Independence

13. HINRI Labs – Action Plan HINRI Labs © 2008 1A Complete SCI Measurement – Neural Plasticity, Functional Recovery Electrophysiology and Robotics 1B Complete SCI Translation – Bench to Bedside Assistive Technology, Holistic Medicine, Stem Cell Research 2 Brain Injury Measurement and Translation Imaging, Surgery, Pharmaceuticals, Stem Cells, Emerging Therapies 3 Neuro-Disease Neural Injury and Degeneration - Cell death, nerve regeneration and reconnection Basic Research Phase Target Focus Method

15. HINRI Labs Timeline 2009 JAN FEB MAR APR MAY JUN JUL AUG SEP OCT NOV DEC Atlanta – 1A ($3 MM) Atlanta – 1B ($5 MM) Palo Alto – 1A* ($10 MM) Boston – 1A ($2.5 MM) Atlanta – 2 ($7.5 MM) Atlanta – 3 ($5 MM) Phase HINRI Labs © 2008 *10 MM to be raised for Dr. Gary Steinberg and Dr. Graham Creasey at Stanford

16. Test & Develop Best Practices Rehabilitation Business Model Promote/Conduct Clinical Trials Restoration Collaborate on Best Practices Rehabilitation Foundations & Charities Common Mission Collaborate on Best Practices Rehabilitation Venture Philanthropy Common Goals Coordinate & Support Research Strategic Partners Collaboration Translational US Military Wounded Veterans Patients Patient Centered Clinical & Lifestyle Recovery Government, VA, Private Insurance Capital