The presentation my group made to explain the lysosome and a little on the Tay-Sachs disease. This was also uploaded to the maTrix.

1. TSD and the lysosome: maTrix edition Created by: Phagocytes, TJC CG 30/06 This presentation has been edited to reduce its file size. A Quick Note

2. Tay-Sachs Disease and the lysosome LEFT: Akari Yamada holds her son, Davis Jr., nicknamed DJ. He suffers from Tay-Sachs, a rare disease that has left him blind and taken away most of the skills he had as a baby . Daily Herald Photo/ Bill Zars Tay-Sachs Disease Lysosome

3. In This Presentation What is TSD? Genetically Speaking… e - Micrograph Functions About TSD (Tay-Sachs Disease) Structure About the Lysosome Structure-Function Among Organelles The Lysosome’s Relationships

4. Brain and nerve cells become damaged and gradually lose their ability to function properly. About TSD What is TSD? Genetic disorder caused by a deficient enzyme which results in the extreme accumulation of a fatty substance in the nervous system. No cure; death by about age 5 hex-A ganglioside GM2 Tay-Sachs Disease is… the lysosomes don’t contain a certain enzyme to break down a certain fat… a lysosomal storage disease! Fatty materials Normal brain cell Tay-Sachs brain cell 1) Development of mental and motor f(x) fails. 2) Nervous system is shut down.

6. About the Lysosome URL ASF Structure Generally… what the lysosome is about TSD and the lysosome: maTrix edition Source: United Streaming Saved As: lysosomes (general) (unitedstreaming).asf The video clip has been removed to reduce file size.

8. About the Lysosome e - Micrograph

10. About the Lysosome Functions 1.Digestion of materials from phagocytosis 2.Autophagy (Autophagocytosis) URL ASF TSD and the lysosome: maTrix edition Source: United Streaming Saved As: lysosomes (phagocytosis) (unitedstreaming).asf The video clip has been removed to reduce file size.

11. About the Lysosome Functions 3.Autolysis Example with tadpole URL ASF TSD and the lysosome: maTrix edition Source: United Streaming Saved As: lysosomes (tadpole) (unitedstreaming).asf The video clip has been removed to reduce file size.

14. X Quick summary of lysosomes TSD and the lysosome: maTrix edition Source: McGraw-Hill Saved As: lysosomes (mcgraw-hill).swf The video clip has been removed to reduce file size.

15. Tay-Sachs Disease and the lysosome Thank you for your kind attention.