1. Current Indications for Endoscopic Transoral Incisionless Fundoplication - TIF Stefan J.M. Kraemer, M.D . [email_address] July 24, 2008
2.
3.
4.
5. But the Root Cause in Moderate/Severe GERD is Anatomical changes (LES) Angle of HIS Fundus Diaphragm Z - Line (LES) Angle of HIS Fundus Gastroesophageal Flap Valve (GEV) Esophagus Diaphragm Z - Line Lower Esophageal Sphincter Normal Anatomy GERD
9. Excellent Results for Curing Esophagitis and Ulcer Loss of efficacy Side-effects such as dry mouth Calcium and Iron absorption Gastric polyps Bacterial gastroenteritis Unclear cancer risk Only short-term indication cleared PPIs Under Increasing Pressure
10. Lundell et al. British Journal of Surgery 2007; 94: 198-203 Conclusion : After 7 years, surgery was more effective in controlling overall symptoms of chronic GERD , but specific post-fundoplication complaints remained a problem. With Clinical Data of TIF Approaching Reported Data on LARS…
23. Pharmaceutical Palliation; treatment of esophagitis and ulcer Surgical Treatment of anatomical root cause Severe GERD Hiatal hernia Mild GERD Before EsophyX 12 mo after EsophyX Functional Change Anatomic Change Mechanism and Progression of GERD Tranoral Incsionless Fundoplication TIF2
Here is an animated video of the EsophyX ELF procedure. The device rides over a standard endoscope. One technical challenge is that the device needs to be flexible and soft to make the 90 degree bend in the throat, then stiff and strong to perform surgery in the stomach. The endoscope is always introduced first so that the entire procedure is performed under visual control. The stomach is insufflated and the endoscope is placed in retroflex view. Under visual control, the device is advanced into the stomach. Before creating the valve, the anatomy needs to be in the correct configuration, so any hiatal hernia is reduced first. To do this, the endoscope is retracted back into the EsophyX device up to the clear window in the shaft of the device. Through this window the z-line is visualized. Once located, the invaginator is engaged which uses suction to bring the esophagus onto the shaft of the device. The device is advanced to elongate the esophagus, bringing the z-line to the level of the diaphragm, thus reducing hiatal hernia. Now that the anatomy is in the correct configuration, the valve can be created. The endoscope is advanced and returned to retroflex view. The tissue mold is partially closed, and the helical retractor is advanced out the tip of the tissue mold and twisted to engage it in the fundus tissue. The mold is opened out of the way and a long flap of tissue is pulled down (3-5 cm long flap). The flap mold is closed to compress the tissue and fasteners are delivered across the top of this length of tissue. This shows a close up of the fastener delivery, with the sylet pushing across, and the trailing leg, then lead leg of the H fastener dropping, as the fastener is pushed until it drops off the stylet. These are tension-free fasteners, because they do not put tension on the tissue in any one place. 2 fasteners (one posterior and one anterior) can be delivered at any one placement of the tissue mold. The system is disengaged, you move to a new location of the valve and repeat this procedure until a 270-310 degree circumference, tight valve has been created.