MDROs are microorganisms that are resistant to one or more classes of antimicrobial agents such as MRSA, VRE, and certain gram-negative bacteria. They are transmitted through the same routes as other pathogens but can be more difficult to treat. Hospitals have implemented isolation precautions and infection control strategies to prevent transmission and properly manage MDROs. These include contact precautions, surveillance testing, antibiotic stewardship programs, and guidelines from the CDC for identifying and containing MDROs, especially for at-risk patients and units. A multidisciplinary approach is needed between clinical staff, microbiology laboratories, and infection prevention teams to effectively control MDROs.