2. Presented by P.Bindu, M.Pharmacy 1 st year, Department of Pharmacology, Sri padmavathi mahila viswavidyalayam, Tirupati.

14. Ligand binding site

19. GATING MECHANISM IN GABA A RECEPTOR

23. MOLECULAR STRUCTURE

29. G-PROTEIN RECEPTOR FOR SIGNALLING PATHWAY G O NT ,Opioid cannabinoid Not clear G q mAchR, serotonin 5HT 1C PLC IP 3 , DAG Cytoplasmic Ca G t1 , G t2 Rhodopsin and colour opsins in retinal rod and cone cells cGMP phosphodiesterase- cGMP

36. RHO A / RHO KINASE SYSTEM

38. Structure of Kinases linked receptors Y Y Y Y Y Y Extracellular domain Binds to the ligand (growth factor) Trans membrane domain Intracellular domain Endogenous kinases bind and get phosphorlated

40. Kinase cascade Gene transcription

43. Zn fingers;hor response elements -Binds with corepressor coactivator ptns AF 1 AF 2

45. homo HRE- hormone response elements CLASS - I

46. CLASS II

47. COMPARISON OF RECEPTORS TYPES INOTROPIC METABOTROPIC KINASE LINKED NUCLEAR NO.OF FAMILIES 483 217 135 48 LOCATION MEMBRANE MEMBRANE MEMBRANE INTRACELLULAR TIME SCALE MILLI SECONDS SECONDS HOURS HOURS COUPLING DIRECT VIA G-PROTIEN DIRECT VIA DNA EXAMPLES nAchR, GABA A ADRENOCEPTORS, mAchR INSULIN CYTOKINES GF STEROIDS