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Introduction to defense systems of the body ,[object Object],[object Object],[object Object]
The non-specific defenses of our  normal flora ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The non-specific defenses of our normal flora ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Examples of interruption of normal flora ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
C. difficile  and antibiotic-associated colitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],C diff  proliferation
Acids as a barrier ,[object Object],[object Object],[object Object],[object Object],[object Object]
The epidermis as a mechanical barrier ,[object Object],[object Object],[object Object],[object Object],[object Object]
The anti-microbial role of surface acid ,[object Object],[object Object],[object Object],[object Object],[object Object]
Antibacterial “lysozyme” ,[object Object],[object Object],[object Object]
The respiratory mucociliary escalator  ,[object Object],[object Object],[object Object],[object Object]
Natural chemical protection against the spread of viral infections:  interferon ,[object Object],[object Object],[object Object]
Cellular response to viral infection:  INTERFERON
Our 1 st  line of defense against invading bacteria: neutrophils ,[object Object],[object Object],[object Object],[object Object]
NEUTROPHILS are attracted to bacteria ,[object Object],[object Object],Infection- bacteria cause release of the chemical signals
Macrophages are “multi-taskers” ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
“ Activated” macrophages and fever production ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
A macrophage has various microbe-specific receptors on its surface ,[object Object],[object Object],[object Object],[object Object],[object Object]
Another chemical defense: the “defensins” ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Introduction to defense systems of the body ,[object Object]
Overview of the lymphatic system ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
The specific defense system: the IMMUNE SYSTEM   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The origins of lymphocytes (B-cell and T-cells) ,[object Object],[object Object],[object Object],[object Object],[object Object]
The steps involved in activating the immune system ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The macrophage as an APC ,[object Object],[object Object]
Activating a B-cell ,[object Object],[object Object],[object Object],[object Object],[object Object]
The 5 classes of antibodies/immunoglobins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The 5 antibody classes ,[object Object],[object Object],[object Object],[object Object]
Antibody class-switching from IgM to IgG ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
How pathogens are destroyed by antibodies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
3 roles of antibodies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The multiple roles of pathogen-bound antibodies ,[object Object],[object Object]
The antibody-activation of complement ,[object Object],[object Object]
Cytotoxic T-cell response to viral infections ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The cytotoxic T-cell and cell-mediated cytotoxicity ,[object Object],[object Object],[object Object],[object Object],[object Object]
Perforin molecules put holes in the infected cell
The perforin molecules of cytotoxic T-cells ,[object Object],[object Object],[object Object],[object Object],[object Object]
Antibody-dependent cell-mediated cytotoxicity: (ADCC) ,[object Object],[object Object],[object Object]
B-cell activation independent of helper T-cells ,[object Object],[object Object],[object Object],[object Object],[object Object]
The activated B-cell: memory B cell and plasma cell clones
Antibody class-switching from IgM to IgA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Natural immunity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Vaccines and immunization ,[object Object],[object Object],[object Object],[object Object],[object Object]
Vaccines: an artificial mechanism of active immunity ,[object Object],[object Object],[object Object],[object Object],[object Object]
Memory cells are essential for a 2 0  response ,[object Object],[object Object],[object Object]
Vaccines and “length” of immunity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Long-term vaccines given to children in the USA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
More long-term vaccines ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Need for other vaccines ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
Immunological clinical tests for infections ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Latex bead-bound antibody tests for pathogens   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The ELISA tests ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The indirect ELISA test to  detect antibodies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The direct ELISA test to  detect antigen ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The Western blot test ,[object Object],[object Object],[object Object],[object Object],[object Object]
Florescent-linked antibody tests for pathogens ,[object Object],[object Object],[object Object]
Immune system disorders ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
An allergy is a type I hypersensitivity ,[object Object],[object Object],[object Object],[object Object],[object Object]
Anaphylactic shock is a severe type I hypersensitivity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
HDNB is a Type II hypersensitivity ,[object Object],[object Object],[object Object]
Drug-induced thrombocytopenic purpura is a Type II hypersensitivity ,[object Object],[object Object],[object Object]
Post-streptococcal acute glomerulonephritis is a type III hypersensitivity ,[object Object],[object Object],[object Object],[object Object]
A poison ivy rash is a type IV hypersensitivity ,[object Object],[object Object],[object Object]
The tuberculin skin test utilizes type IV hypersensitivity   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Auto-immune diseases ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Examples of autoimmune diseases ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Transplants and immunosuppression ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Immune deficiencies ,[object Object],[object Object],[object Object]
Latent and active HIV infection ,[object Object],[object Object],[object Object]
The progression of an HIV infection
HIV antiviral drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Introduction to antimicrobial drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Introduction to antibiotics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Narrow-spectrum antibiotics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The penicillin tree ,[object Object],[object Object],[object Object],[object Object],[object Object]
Beta-lactam ring narrow-spectrum antibiotics
Penicillin drugs inhibit bacterial cell wall synthesis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MRSA  Staphylococcus aureus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Vancomycin and Bacitracin inhibit bacterial cell wall synthesis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Penicillinase is an enzyme of bacterial drug resistance ,[object Object],[object Object],[object Object],[object Object],[object Object]
Semi-synthetic penicillins have a “broader” affect ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Other beta-lactam drugs that disrupt peptidoglycan synthesis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Erythromycin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],A 70S bacterial ribosome
“ Zyvox” ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Antibiotics and “the pill” ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The natural penicillin drugs ,[object Object],[object Object],[object Object]
Broad spectrum drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The 70s RIBOSOME is a major target ,[object Object],[object Object]
Broad-spectrums that interfere with bacterial protein synthesis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Broad-spectrum drugs that inhibit bacterial protein synthesis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Antimicrobials that inhibit bacterial nucleic acid synthesis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Sulfa drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Summary of antibiotic modes of action
Drug resistance
Targets of antibacterial drugs
Drug resistance
The disk-diffusion test to assess drug effectiveness ,[object Object],[object Object],[object Object],[object Object],[object Object]
Drug treatment for TUBERCULOSIS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Some bacterial strategies against drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
An antibiotic that damages the plasma membrane of bacteria ,[object Object],[object Object]
Anti-viral herpes drugs: ACYCLOVIR ,[object Object],[object Object],[object Object],[object Object],[object Object]
Cellular response to viral infection:  INTERFERON
Other antiviral drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Anti-fungal, -protozoan, and –helminth drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
A graph of anti-septic effectiveness ,[object Object],[object Object],[object Object],[object Object]
Sterilization: the AUTOCLAVE and filtering ,[object Object],[object Object],[object Object],[object Object]

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Biology Exam 2

Notas do Editor

  1. For artificially acquired immunity, what’s the difference between active and passive, which is better and why?
  2. Active infections = the highest time which you’re body is producing the most antibodies