This document discusses systemic lupus erythematosus (SLE), also known as lupus, which is a chronic autoimmune disease that can affect multiple systems of the body. It presents in episodes or flares and remissions. Common symptoms in teens include fever, rash, mouth sores, and hair loss. Organs that can be involved include the blood, joints, skin, kidneys, heart, and lungs. Treatment focuses on minimizing symptoms, preventing organ damage, and reducing toxicity through medications like hydroxychloroquine and prednisone. With treatment, long-term outcomes have improved significantly, though organ damage can still occur in severe cases. An optimal treatment approach requires a multidisciplinary team and