1. Medical Imaging Technologies for
Ocular Disease Primary
O l i i
Care Screening
Jimmy Liu
jliu@i2r.a‐star.edu.sg
Institute for Infocomm Research (I2R)
March 2012

2. I2R Technologies on Different Image
Modalities for Major Ocular Disease
M d liti f M j O l Di
Primary Care Screening

3. Major Causes of Blindness
Causes of blindness as a percentage of total blindness
C f bli d t f t t l bli d
“Global data on visual impairment in the year 2002”
World Health Organization Bulletin

4. Ocular Diseases Primary Care Screening
Automatic Cataracts grading from Lens images
g g g
Automatic Cup‐to‐Disc Ratio (CDR) Calculation from fundus
images for Glaucoma screening
Automatic Glaucoma subtype classification from RETCAM
images
Automatic Glaucoma subtype classification from OCT images
Automatic Glaucoma subtype classification from OCT images
Automatic Drusen detection from fundus images for AMD
assessment
Automatic Cornea Analysis from OCT images
Automatic Pathological Myopia screening from fundus images

5. AGLAIA
Architecture for Automatic
GLaucoma Diagnosis and Its Genetic
Association Study through Medical
Image InformAtics

6. Glaucoma
Irreversible loss of optic nerves
p
Second leading cause of blindness
5.7 million glaucoma blind (total 38 million blind in the world)
Glaucoma can be slowed if detected early

7. Validation
Air puff eye
pressure
measurement
N = 1,676 subjects
Diagnostic
Mean Age: 57.7 years performance
Retinal fundus
Gender (M/F): 832 / 844 analysis:
photography + Receiver
Mean CDR: 0 40
0.40 AGLAIA Operating
(range: 0.10 to 0.95)
Characteristic
(ROC) curve
(Glaucoma Dx: 46 subjects
(2.7%))
(2 7%)) Full
ophthalmic
exam at SERI

8. Results

9. We look forward to working with you