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1.
2.
3.
4.
5.
Signal transduction: on
and off Weinberg, Sci Am 275-3, 1996, 32-40 Avoid words such as ‘fires’
6.
7.
8.
9.
The cell cycle
Weinberg, Sci Am 275-3, 1996, 32-40
10.
The cell cycle
Weinberg, Sci Am 275-3, 1996, 32-40
11.
12.
The pRb switch
Weinberg, Sci Am 275-3, 1996, 32-40 E2F-member
13.
The cell cycle
Weinberg, Sci Am 275-3, 1996, 32-40
14.
The pRb switch
Weinberg, Sci Am 275-3, 1996, 32-40 E2F-member
15.
Progression to cell
division Weinberg, Sci Am 275-3, 1996, 32-40 mdm2 p21 p21 waf : see Vogelstein Proteins involved in DNA synthesis Liberated Transcription factors Active pRb protein complexed with inactive transcription factors (master brake) Transforming growth factor ß (an inhibitor) Cell division DNA synthesis Growth promoting signals issued vy neighboring cells
16.
Progression to cell
division Weinberg, Sci Am 275-3, 1996, 32-40 mdm2 p21 p21 waf : see Vogelstein Proteins involved in DNA synthesis Liberated Transcription factors Active pRb protein complexed with inactive transcription factors (master brake) Transforming growth factor ß (an inhibitor) Cell division DNA synthesis Growth promoting signals issued vy neighboring cells
17.
18.
Effect of activating
c-myc (from Alberts et al. 2002)
19.
Effect of activating
c-myc (from Alberts et al. 2002)
20.