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Factors influencing force of contracton
1. FACTORS INFLUENCING FORCE OF CONTRACTION
MOTOR UNIT RECRUITMENT
FATIGUE
RK Goit, Lecturer
Department of Physiology
2. The Muscle Twitch
the mechanical response of a muscle fiber to a
single action potential
starts about 2 ms after the start of depolarization
of the membrane
3.
4. Peak tension
an ocular muscle- 7.5 msec (fast twitch fibers)
gastrocnemius muscle- 40 msec (mixture of fast
& slow twitch fibers)
soleus muscle- about 90msec (slow twitch fibers)
ocular movements must be extremely rapid to
maintain fixation of the eyes on specific objects
gastrocnemius muscle must contract moderately
rapidly to provide sufficient velocity of limb
movement for running & jumping
soleus muscle is concerned with slow contraction
for continual, long-term support of the body
5. Classification of skeletal muscle fiber types
Type I Type II
Other names Slow; Oxidative; Red Fast; Glycolytic; White
Myosin ATPase activity Low High
Ca2+ Pumping capacity of
sarcoplasmic reticulum
Moderate High
Diameter Moderate Large
Glycolytic capacity Moderate High
Oxidative capacity High Low
Twitch duration 100 ms 7.5 ms
Number of fibers Few (100-500) Many (1000-2000)
Contraction velocity Moderate Fast
Fatigability Low high
Motor unit size Small Large
Size of motor neuron Small Large
Function Concerned with strong,
gross, sustained
movements
Concerned with fine,
rapid, precise movement
8. increase in muscle tension from successive action
potentials -summation
a maintained contraction in response to repetitive
stimulation -tetanus
at low stimulation frequencies, the tension may
oscillate as the muscle fiber partially relaxes
between the stimuli-unfused tetanus
a fused tetanus, with no oscillation, is produced at
higher stimulation frequencies
9. Fatigue
decrease in performance due to continuous &
prolonged activity
can occur in the whole organism or in isolated
preparations
is a reversible phenomenon & there is no
permanent functional or structural damage to the
tissue
if a muscle is allowed to rest after the onset of
fatigue, it can recover its ability to contract upon
restimulation
10. Major sites of fatigue
Central nervous system
encouragement & motivation increases the
performance of the subject
encouragement stimulates the frontal lobe of the
cortex that increases the activity in the motor
cortex
Neuromuscular junction
exhaustion of ACh
fast twitch muscle fibers seem to be more prone
to fatigue while slow fibers get fatigued later on
11. Muscle
Depletion of energy reserves
Depletion of creatine phosphate & glycogen
Accumulation of metabolites
↑ lactic acid concentration
↓ pH
↓ affinity of Ca++ for troponin
Inhibits some key glycolytic enzymes (glycogen
phosphorylase & phosphofructokinase)
Accumulation of Ca++ in T-tubules
Motor nerve
nerve is theoretically unfatiguable
12. Recruitment
the process of increasing the number of motor
units that are active in a muscle at any given time
slow twitch motor units tend to be small (100 to
500 muscle fibers) & is easily excited
fast twitch motor units tend to be large (1000 to
2000 muscle fibers) & are more difficult to excite
slow twitch motor units tend to be recruited first
fast twitch motor units are recruited when more &
more force is needed
13. process of increasing the force of contraction by
recruiting additional motor units is called
summation
14. Factors determining force of contraction
1. Action potential frequencies (frequency-
tension relation)
2. Fiber length (length-tension relation)
3. Fiber diameter
4. Fatigue
5. Number of active fibers
15. References
Berne & Levy Physiology, 6/E
Ganong Review of Medical Physiology, 23/E
Textbook of Medical Physiology, 12/E Guyton &
Hall
Understanding Medical Physiology, 4/E Bijlani &
Manjunatha
Vander’s Human Physiology: The Mechanisms of
Body Function, 11/E