This document summarizes an MRSA eradication program implemented at New England Baptist Hospital. It describes increasing rates of MRSA infections, both in the hospital and community. The hospital implemented universal pre-operative MRSA/MSSA screening and decolonization treatment for patients undergoing inpatient surgery to reduce surgical site infections. Rapid PCR testing was used to screen over 6,000 patients annually. While costly to implement, the program aimed to improve patient outcomes and reduce costs associated with treating surgical site infections. Preliminary results showed reduced MRSA colonization and bacteremia post-surgery.