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AMR Collaborative Grants at the University of Bristol
- 1. Dr Matthew B. Avison, Senior Lecturer in Microbiology School of Cellular & Molecular Medicine AMR Collaborative Grants at the University of Bristol
- 2. AMR transmission in the real world. • Dairy Farming uses a lot of cephalosporins. • Is there a link with AMR and can it be reversed? • Do dogs and people pick up E. coli from the environment? • Is there a link to UTIs caused by Cephalosporin Resistant E. coli in humans? • And can this be reversed? 2 Theme 3
- 3. AMR transmission in the real world. 3 Theme 3
- 4. 4
- 5. 5 Driving Down Antibiotic Usage on Farms.
- 6. Proteomics to Identify AMR. 6 Theme 2
- 7. 7 •Comparative proteomics to identify putative mechanisms of resistance. E.g. coming out of pK/pD models. •Knockouts/over-expression studies to confirm involvement in AMR and relative importance. •Surveys of clinical isolates to identify if novel AMR mechanism is present; how different mechanisms work together. •Impact includes development of strain collections. Identifying AMR Mechanisms.
- 8. 8 Finding New Antibiotic Lead Compounds Theme 2