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Meningococcemia - Pediatric

   History
   2 y/o boy. Taken to Pediatrician with history of sudden onset of fever, vomiting
   and lethargy for 4 hours.
   Referred to walk-in clinic at hospital.

   Presentation
   Drowsy and pale, dark rings around eyes
   Temperature 38.7o C
   CVS:     HR 180 bpm,
            BP 70/26 mmHg
            Cool peripheries, capillary refill time 5 sec
   RS:               RR 54 ipm, dyspnea, cyanosis
                              SaO2 100% in oxygen
   NS:               GCS 10 then 9, no neck stiffness
   Fine blanching rash on abdomen/chest. Petechial spot on the face.
www.uscom.com.au                                   The Measure of Life
Meningococcemia - Pediatric
                      Distance blood cell travels / minute
                                                               Treatment
   Parameter            Base               Age wise            Fluid bolus 40 ml/kg
                        Measure            norms               Epinephrine 0.15 mcg/kg/min
   MD (m/min)           12                 18-30
                                                                      Hypodynamic
   SVI   (ml/m2)        30                 40-55
   SV (ml/kg)           1.2                1.5-2.4
   SVV (%)              45                 <15                        Hypovolemia /
   FTc (ms)             278                300-375                   Fluid responsive
   HR                   180                85-115
   SVRI (d.s.cm/m2)     1120               1000-1600                Normal Systemic
   SVR (d.s.cm)         1889               1500-2000               Vascular Resistance
   CI (l/min/m2)        2.8                3.5-5.0
   CO (l/min)           2.0                2.5-4.0
                                                                    Low Cardiac Index
   Vpk (ms)             0.8                1.1-1.6

www.uscom.com.au                                             The Measure of Life
Meningococcemia - Pediatric

   60 minutes
   Sedated, mechanical ventilation
   Afebrile
   CVS:     HR 180 - 150 bpm,
            BP 70/26 - 90/30 mmHg
            Capillary refill time 5 - 3 sec
   Acidosis improved
   SaO2 100% in oxygen




www.uscom.com.au                              The Measure of Life
Meningococcemia - Pediatric
                                                  Treatment
   Parameter          Base   60mins   Age wise    Fluid bolus 20 ml/kg
                                      norms       Norepinephrine 0.1 mcg/kg/min
   MD (m/min)         12     21       18-30
                                                       Normodynamic
   SVI   (ml/m2)      30     50       40-55
   SV (ml/kg)         1.2    20       1.5-2.4
   SVV (%)            45     38       <15              Hypovolemia /
   FTc (ms)           278    312      300-375         Fluid responsive
   HR                 180    150      85-115
   SVRI (d.s.cm/m2)   1120   690      1000-1600        Low Systemic
   SVR (d.s.cm)       1889   899      1500-2000     Vascular Resistance
   CI (l/min/m2)      2.8    3.8      3.5-5.0
   CO (l/min)         2.0    2.6      2.5-4.0            Adequate
   Vpk (ms)           0.8    1.3      1.1-1.6           Cardiac Index

www.uscom.com.au                            The Measure of Life
Meningococcemia - Pediatric

   Sedated, mechanical ventilation
   Afebrile
   CVS:     HR 150 - 115 bpm,
            BP 90/30 - 100/48 mmHg
            Capillary refill time 3 - < 2 sec
   No acidosis




www.uscom.com.au                                The Measure of Life
Meningococcemia - Pediatric
                                                    Treatment
   Parameter        Base   60min 90min Age wise
                                                    Fluid bolus 20 ml/kg
                                       norms
                                                    Norepinephrine 0.2
   MD (m/min)       12     21    32     18-30       mcg/kg/min
   SVI (ml/m2)      30     50    58     40-55
   SV (ml/kg)       1.2    20    2.6    1.5-2.4
   SVV (%)          45     38    19     <15
                                                      Mild volume
   FTc (ms)         278    312   310    300-375
                                                       deficit and
   HR               180    150   112    85-115        vasodilation
   SVRI (d.s.cm/m2) 1120   690   897    1000-1600
   SVR (d.s.cm)     1889   899   1324   1500-2000
   CI (l/min/m2)    2.8    3.8   4.6    3.5-5.0
   CO (l/min)       2.0    2.6   3.8    2.5-4.0
   Vpk (ms)         0.8    1.3   1.5    1.1-1.6

www.uscom.com.au                          The Measure of Life
Meningococcemia - Pediatric

   Summary
   Paracetamol and appropriate antibiotics for meningococcemia were given
   within the first hour. Hemodynamics monitored as appropriate treatment
   administered.

   Conclusion
   USCOM gave guidance during the resuscitation, in a very rapid way, without
   any invasive procedure.




www.uscom.com.au                                 The Measure of Life

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Non-invasive hemodynamic monitoring guides resuscitation in pediatric meningococcemia

  • 1. Meningococcemia - Pediatric History 2 y/o boy. Taken to Pediatrician with history of sudden onset of fever, vomiting and lethargy for 4 hours. Referred to walk-in clinic at hospital. Presentation Drowsy and pale, dark rings around eyes Temperature 38.7o C CVS: HR 180 bpm, BP 70/26 mmHg Cool peripheries, capillary refill time 5 sec RS: RR 54 ipm, dyspnea, cyanosis SaO2 100% in oxygen NS: GCS 10 then 9, no neck stiffness Fine blanching rash on abdomen/chest. Petechial spot on the face. www.uscom.com.au The Measure of Life
  • 2. Meningococcemia - Pediatric Distance blood cell travels / minute Treatment Parameter Base Age wise Fluid bolus 40 ml/kg Measure norms Epinephrine 0.15 mcg/kg/min MD (m/min) 12 18-30 Hypodynamic SVI (ml/m2) 30 40-55 SV (ml/kg) 1.2 1.5-2.4 SVV (%) 45 <15 Hypovolemia / FTc (ms) 278 300-375 Fluid responsive HR 180 85-115 SVRI (d.s.cm/m2) 1120 1000-1600 Normal Systemic SVR (d.s.cm) 1889 1500-2000 Vascular Resistance CI (l/min/m2) 2.8 3.5-5.0 CO (l/min) 2.0 2.5-4.0 Low Cardiac Index Vpk (ms) 0.8 1.1-1.6 www.uscom.com.au The Measure of Life
  • 3. Meningococcemia - Pediatric 60 minutes Sedated, mechanical ventilation Afebrile CVS: HR 180 - 150 bpm, BP 70/26 - 90/30 mmHg Capillary refill time 5 - 3 sec Acidosis improved SaO2 100% in oxygen www.uscom.com.au The Measure of Life
  • 4. Meningococcemia - Pediatric Treatment Parameter Base 60mins Age wise Fluid bolus 20 ml/kg norms Norepinephrine 0.1 mcg/kg/min MD (m/min) 12 21 18-30 Normodynamic SVI (ml/m2) 30 50 40-55 SV (ml/kg) 1.2 20 1.5-2.4 SVV (%) 45 38 <15 Hypovolemia / FTc (ms) 278 312 300-375 Fluid responsive HR 180 150 85-115 SVRI (d.s.cm/m2) 1120 690 1000-1600 Low Systemic SVR (d.s.cm) 1889 899 1500-2000 Vascular Resistance CI (l/min/m2) 2.8 3.8 3.5-5.0 CO (l/min) 2.0 2.6 2.5-4.0 Adequate Vpk (ms) 0.8 1.3 1.1-1.6 Cardiac Index www.uscom.com.au The Measure of Life
  • 5. Meningococcemia - Pediatric Sedated, mechanical ventilation Afebrile CVS: HR 150 - 115 bpm, BP 90/30 - 100/48 mmHg Capillary refill time 3 - < 2 sec No acidosis www.uscom.com.au The Measure of Life
  • 6. Meningococcemia - Pediatric Treatment Parameter Base 60min 90min Age wise Fluid bolus 20 ml/kg norms Norepinephrine 0.2 MD (m/min) 12 21 32 18-30 mcg/kg/min SVI (ml/m2) 30 50 58 40-55 SV (ml/kg) 1.2 20 2.6 1.5-2.4 SVV (%) 45 38 19 <15 Mild volume FTc (ms) 278 312 310 300-375 deficit and HR 180 150 112 85-115 vasodilation SVRI (d.s.cm/m2) 1120 690 897 1000-1600 SVR (d.s.cm) 1889 899 1324 1500-2000 CI (l/min/m2) 2.8 3.8 4.6 3.5-5.0 CO (l/min) 2.0 2.6 3.8 2.5-4.0 Vpk (ms) 0.8 1.3 1.5 1.1-1.6 www.uscom.com.au The Measure of Life
  • 7. Meningococcemia - Pediatric Summary Paracetamol and appropriate antibiotics for meningococcemia were given within the first hour. Hemodynamics monitored as appropriate treatment administered. Conclusion USCOM gave guidance during the resuscitation, in a very rapid way, without any invasive procedure. www.uscom.com.au The Measure of Life

Notas do Editor

  1. Low MD - 12 (Typical 18-30) = Hypodynamic circulationLow SVI &amp; High SVV = probably HypovolemiaNormal SVRI – 1120 (Typical 1000-1600)Low CI – 2.8 (Typical 3.5-5.0)Low Vpk – 0.8 (Typical 1.1-1.6)Epinephrine (also known as adrenaline) is used as a drug to treat cardiac arrest and other cardiac dysrhythmias resulting in diminished or absent cardiac output. Its actions are to increase peripheral resistance via α1receptor-dependent vasoconstriction and to increase cardiac output via its binding to β1 receptors.http://en.wikipedia.org/wiki/Epinephrine
  2. Normal MD - 21 (Typical 18-30) =Normodynamic circulationNormal SVI 50 &amp; Normal-Low FTc 312 = probably mild HypovolemiaLowSVRI – 690 (Typical 1000-1600) = Relative HypovolemiaNormal CI – 3.8 (Typical 3.5-5.0)Normal Vpk – 1.3 (Typical 1.1-1.6)
  3. Normal MD - 32 (Typical 18-30) =Normodynamic circulationNormal SVI 58, CI 4.6 &amp; FTc 310 = Relative HypovolemiaLowSVRI – 897 (Typical 1000-1600) = HypovolemiaNormal Vpk – 1.5 (Typical 1.1-1.6)