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Parkinsonism
1.
DR.UMA KADAM
M.B.B.S. MD ASSOCIATE PROFESSOR PHARMACOLOGY SKNMC
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GABA DOPAMINE ACETYLCHOLINE
PARKINSONISM + -
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↓ GSH Mitochondrial
Damage ↑ H 2 O 2 FREE RADICALS Cell Death Mitochondrial Damage Excitotoxicity ↑ Cytosolic Ca 2+ Ca 2+ activated Degradative enzymes DA Fe 2+ ↑ Free radical Production (?PD) ↓ Free radical Defenses (?ALS)
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THANK YOU