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L
10




                 L

100mg                 2μg/ml(=2mg/L)
100(mg)/2(mg/L)=50L
                          1kg         ...
11
12




(L)=   (mg)/               (mg/L)



               Vd (L/kg)

               0.3

         0.5-1

                ...
13
14
15
16




    1-1.5mg/kg




17mg/kg
17




                   1.5mg/kg        ×
                                                        10


        50kg     ...
18




                     1.5mg/kg      ×


         50kg                                    Vd
Vd=1.1L/kg
×Vd 50kg×1.1L...
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                                  17mg/kg
                                3.6            30


        50kg         ...
20




                                                  17mg/kg


              50kg
Vd                Vd=1.9L/kg

     ×...
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    50kg                          250mg


                  50kg                                    Vd


          ...
22




    50kg                              250mg


                   50kg                                     Vd
      ...
23




    1-1.5mg/kg




17mg/kg
24
25
26




               (CCB)




loading dose
27
28




4   5
29




4         5
    95%
30
31




H2 blocker



      iatrogenic
32




             4




iatrogenic
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Pharmacokinetics icu setting_2007_nagoya Slide 1 Pharmacokinetics icu setting_2007_nagoya Slide 2 Pharmacokinetics icu setting_2007_nagoya Slide 3 Pharmacokinetics icu setting_2007_nagoya Slide 4 Pharmacokinetics icu setting_2007_nagoya Slide 5 Pharmacokinetics icu setting_2007_nagoya Slide 6 Pharmacokinetics icu setting_2007_nagoya Slide 7 Pharmacokinetics icu setting_2007_nagoya Slide 8 Pharmacokinetics icu setting_2007_nagoya Slide 9 Pharmacokinetics icu setting_2007_nagoya Slide 10 Pharmacokinetics icu setting_2007_nagoya Slide 11 Pharmacokinetics icu setting_2007_nagoya Slide 12 Pharmacokinetics icu setting_2007_nagoya Slide 13 Pharmacokinetics icu setting_2007_nagoya Slide 14 Pharmacokinetics icu setting_2007_nagoya Slide 15 Pharmacokinetics icu setting_2007_nagoya Slide 16 Pharmacokinetics icu setting_2007_nagoya Slide 17 Pharmacokinetics icu setting_2007_nagoya Slide 18 Pharmacokinetics icu setting_2007_nagoya Slide 19 Pharmacokinetics icu setting_2007_nagoya Slide 20 Pharmacokinetics icu setting_2007_nagoya Slide 21 Pharmacokinetics icu setting_2007_nagoya Slide 22 Pharmacokinetics icu setting_2007_nagoya Slide 23 Pharmacokinetics icu setting_2007_nagoya Slide 24 Pharmacokinetics icu setting_2007_nagoya Slide 25 Pharmacokinetics icu setting_2007_nagoya Slide 26 Pharmacokinetics icu setting_2007_nagoya Slide 27 Pharmacokinetics icu setting_2007_nagoya Slide 28 Pharmacokinetics icu setting_2007_nagoya Slide 29 Pharmacokinetics icu setting_2007_nagoya Slide 30 Pharmacokinetics icu setting_2007_nagoya Slide 31 Pharmacokinetics icu setting_2007_nagoya Slide 32
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Pharmacokinetics icu setting_2007_nagoya

薬物動態のレクチャー用スライドです。

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Pharmacokinetics icu setting_2007_nagoya

  1. 1. / /
  2. 2. / /
  3. 3. 3
  4. 4. 4
  5. 5. 5
  6. 6. 6
  7. 7. 7
  8. 8. 8
  9. 9. 9 L
  10. 10. 10 L 100mg 2μg/ml(=2mg/L) 100(mg)/2(mg/L)=50L 1kg 1L
  11. 11. 11
  12. 12. 12 (L)= (mg)/ (mg/L) Vd (L/kg) 0.3 0.5-1 >1
  13. 13. 13
  14. 14. 14
  15. 15. 15
  16. 16. 16 1-1.5mg/kg 17mg/kg
  17. 17. 17 1.5mg/kg × 10 50kg Vd ×Vd 50kg×1.1L/kg L kg×1.5mg/kg× mg mg / L mg/L =μg/ml
  18. 18. 18 1.5mg/kg × 50kg Vd Vd=1.1L/kg ×Vd 50kg×1.1L/kg 55 L kg×1.5mg/kg× 150 mg 150 mg / 55 L 2.7 mg/L =μg/ml 2-5μg/ml
  19. 19. 19 17mg/kg 3.6 30 50kg Vd ×Vd 50kg×1.9L/kg L kg×17mg/kg mg mg / L mg/L =μg/ml
  20. 20. 20 17mg/kg 50kg Vd Vd=1.9L/kg ×Vd 50kg×1.9L/kg 95 L kg×17mg/kg 850 mg 850 mg / 95 L 8.95 mg/L =μg/ml 4-10μg/ml
  21. 21. 21 50kg 250mg 50kg Vd ×Vd 50kg×0.5L/kg L 250mg mg / L mg/L =μg/ml →
  22. 22. 22 50kg 250mg 50kg Vd Vd=0.5L/kg ×Vd 50kg×0.5L/kg 25 L 250mg 250 mg / 25 L 10 mg/L =μg/ml 5-15μg/ml >20μg/ml → 10μg/ml 20μg/ml
  23. 23. 23 1-1.5mg/kg 17mg/kg
  24. 24. 24
  25. 25. 25
  26. 26. 26 (CCB) loading dose
  27. 27. 27
  28. 28. 28 4 5
  29. 29. 29 4 5 95%
  30. 30. 30
  31. 31. 31 H2 blocker iatrogenic
  32. 32. 32 4 iatrogenic
  • shioyayumiko

    May. 18, 2017
  • akiraen

    Oct. 24, 2015

薬物動態のレクチャー用スライドです。

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