Open 2013: Teaching Medical Technology Innovation: Lessons learned from a new master's program in translational medicine

Teaching Medical
Technology Innovation
Lessons learned from a new masters program in
translational medicine

Kyle Kurpinski, PhD
Executive Director, Master of Translational Medicine Program
March 21, 2013
NCIIA Open Minds 2013 conference
Masters of Translational Medicine
UC Berkeley/UCSF

What “Bench to bedside”
is “Translational Medicine?”

UC Berkeley / UCSF - Master of Translational Medicine Program UC Berkeley/UCSF

From Bench to Bedside
Problem Discovery Product
(at the lab bench) (at the bedside)
cardiovascular disease Atorvastatin Lipitor

Research Translation
Synthesizing 20 structurally
novel HMGR inhibitors

Early 1960s
Plasma cholesterol
lowered by
As it looked back then
inhibiting synthesis
1962
Triparanol causes
cataracts in humans

1982
Compactin and
lovastatin*
development
suspended due to
pre-clinical toxicity
1985
Atorvastatin
synthesized
1992
Call for a moratorium on
cholesterol-lowering drugs
UC Berkeley / UCSF - Master of Translational Medicine Program *temporarily
UC Berkeley/UCSF

How is translational
medicine different?


What do students need to
know to succeed in this field?


Who are the players?



How do I move a project forward?

Do experiments

Write Publish
grants results

Retire

Image courtesy of The Space Cowboy

Pre-
Pre-clinical FDA
/Clinical
prototyping review
Studies

Needs Write grants and negotiate contracts Start
finding sleeping
and >5 hours
concept Establish Refine a night
Respond Commercial
design Quality Quality again
to FDA manufacturing
System System

Lock down Distribution &
your IP Process marketing
Process
develop-
Pre-IDE* validation Reimbursement
ment
meeting coding

Hire staff and consultants

Years of your life
*Investigational
UC Berkeley / UCSF - Master of Translational Medicine Program Device Exemption
UC Berkeley/UCSF

RockHealth 2011 survey


What do I need to unlearn?
Research
fundamental
problem; multiple
potential end goals

+


Translation
specific end goal; better, cheaper, and/or faster than
the competition

+
$1,000

+
$700

How do we train leaders in
this field?
(Besides letting them try and fail
repeatedly.)


Master of Translational Medicine
(MTM) Overview

MTM Mission: To provide
engineers, clinicians, and life scientists with
the engineering, business, and biomedical
training necessary to take new medical
innovations from initial idea to clinical use.


MTM Program Overview
Bioengineering and Therapeutic
Bioengineering
Sciences
College of Engineering
Schools of Medicine and Pharmacy

Haas School of Business Clinical and Translational Science Institute
School of Public Health Entrepreneurship Center

MTM Curriculum

Bioengineering Clinical/Regulatory
(10 semester (6 semester units)
units)

Capstone Business/Leadership
(8 semester units)
Project

MTM Sample Program
Fall Semester (UCB) Spring Semester (UCB)
Categories
Fall Quarter (UCSF) Winter Quarter (UCSF) Spring Quarter (UCSF) Business /
Engineering Leadership I Engineering Leadership II Leadership
Ethics and Social Issues
in Translational Principles of Magnetic Resonance Imaging Bioengineering
Medicine
“Translational Translational Challenges Clinical /
Challenges in Medicine: in Diagnostics, Devices,
Anti-Medical School” and Therapeutics
Regulatory
Designing Clinical Health Care Finance and Capstone
Research Economics
Project
Physics of Medical
Clinical Trials Idea to IPO
Imaging
Required
CAPSTONE PROJECT* CAPSTONE PROJECT*
Elective
*Project work continues into summer Masters of Translational Medicine

Capstone project

Needs finding Lab projects
• Clinical problem • Research problem
• Limited to early • Early, middle, or
late-stage
stage

Capstone project

Connect students to projects mentored by engineers
and clinicians

Project Example 1:
“Gauss Surgical”

Client: Dr. David Rempel Problem: Monitoring Solution: Modify existing
UCB/UCSF blood loss during surgery technology to help quantify

Notable achievements
– Created and tested initial prototypes
– Now operating as a startup company
– Recently received two 510(k) clearances from FDA

Project Example 2:
“NanoNerve”

Client: Dr. Shyam Patel Problem: Dura mater Solution: Create a synthetic patch
NanoNerve, Inc. repair that enhances dural regeneration

Notable achievements
– Designed and tested prototypes in a canine duraplasty model
– Assisted with submission of SBIR grant proposal
– Multiple publications in progress

MTM Calendar

Program UCSF Fall UCSF Winter UCSF Spring Program
START Quarter Quarter Quarter END

Aug Sep Oct Nov Dec Jan Feb Mar Apr May Jun Jul Aug

UCB Fall UCB Spring
Semester Semester

CAPSTONE PROJECT
Full time
Vetting 15-20 hours/week
(40+ hr/wk)


Master of Translational Medicine vs.
Master of Science
MS MTM
~2 years 11 months (Aug-Jun)

Focus on technology translation
Focus is on basic research
and product development

Curriculum is predominantly Curriculum includes clinical and
science / engineering business components

Individual thesis project Team-based capstone project


Who are we aiming for?
Early stage clinicians
and engineers

• New graduate engineers
• Engineers with 1-4 years
of industry experience
• Late medical school
students and medial
professionals
• Wild cards!

This is all easier said than done

Equipment /
Donors Faculty
supplies
Infrastructure
Sponsors Staff
Projects
Student fees Student aid
Advertising

And yet… it’s working!
San Francisco VA Medical Center
Children’s Hospital Oakland
Kaiser Permanente Various startup companies

Student population is interdisciplinary and growing
35
Medical students / MDs
30
Non-CA resident (non-medical)
25 CA resident (non-medical)
20
15
10
5
0
2010-11 2011-12 2012-13 2013-14 2014-15 2015-16 2016-17

Projected

MTM Graduates – 2012
9 in industry
 Abbott Vascular  Cepheid  InSite Vision
 BD Biosciences  dQ&A Market Research  Pocket Gems
 C1 Consulting  Hansen Medical  Siemens Healthcare
1 in government
 Singapore Economic Development Board, Biomedical
Sciences
2 in medical school
 UC San Diego & UCLA
1 in a PhD program
 U Penn, Biomedical Imaging
3 continuing Capstone project work

The Master of Translational
Medicine Program
Training students how to
transform cutting-edge
medical research into better
patient care
Visit us on the web
bioeng.berkeley.edu/mtm

MTM Executive Director
Kyle Kurpinski, PhD
kkurpins@berkeley.edu
510-664-4472
UC Berkeley/UCSF

Open 2013: Teaching Medical Technology Innovation: Lessons learned from a new master's program in translational medicine

Recomendados

Recomendados

Mais conteúdo relacionado

Semelhante a Open 2013: Teaching Medical Technology Innovation: Lessons learned from a new master's program in translational medicine

Semelhante a Open 2013: Teaching Medical Technology Innovation: Lessons learned from a new master's program in translational medicine (20)

Mais de the nciia

Mais de the nciia (20)

Open 2013: Teaching Medical Technology Innovation: Lessons learned from a new master's program in translational medicine

Notas do Editor