1. PRINCIPLES OF
PHARMACEUTICALS PROCESSING
OF HERBAL AND MINERAL DRUGS
Anand Chaudhary
Associate Professor
Department of Rasa Shastra
Faculty of Ayurveda
Institute of Medical Sciences
Banaras Hindu University
Varanasi
email-anandayubhu@gmail.com

2. Ayurvedic Astuteness

3. Questions /Contents
01- Are the principles of herbal drug processing and mineral
drug processing same ?
02-Are there any parameters to know the physical change
in source material ?
03-What are the reasons for selection of particular process
of particular drug ?
04-What is the basis of selection of particular drugs for
particular formulations ?
CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 3

4. Contd.
05 -What is the relevance of repetition cycles especially for
production of Bhasma and Khalviya rasa kalpa ?
06-Principles of Stability are based on what logic ?
07-Is there any co relation between principles of
formulations applied to Ayurvedic drugs and modern
drugs ?
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5. Herbal Drug – Ayurvedic Medicine
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6. Authoritative Authentication
 Classical considerations
 Contemporary contemplations
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7. Sanitization & Storage
 Separation
 Segregation
 Sustainable
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8. Processing
Mass transfer Solubility
Herbal
Comminution Extraction
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9. Container Consensus
 Primary dosage forms
 Secondary dosage forms
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10. Comminution
Size Reduction
Mechanical Pressure Solvency Procedures
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11. Extraction
 Universal Solvent
 Other Solutions
 Suspensions
 Nano suspensions
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12. Energy Agenda
Natural
Intrinsic Extrinsic
Formulations
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13. Solvents
Aqueous
Oleaginous Alcohol
Oil Ghee Ethyl
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14. Completion Criteria
As per different dosage forms
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15. Procurement & Packing
As per Prepared Medicaments
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16. Delivery & Dispensing
As per indications of Physicians
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17. Mineral Drug – Ayurvedic Medicine
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18. Classical Connotation

19. Individualistic Identification
 Conventional connotations
 Current conjectures
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20. Processing
Shodhan – Specific
Bhavana – Bravura
Marana – Magnificent
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21. Contd .
Jarana
Satvapatan
Amritikaran
Lohitikaran
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22. Adaptations
Modification –
 Physical (Heterogeneous to homogenous)
 Chemical Conversion
 Enhancement
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23. Impacts
 Purification
 Reduction in adverse effects
 Induction of trace elements
 Alteration in Constituencies
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24. Metallographic findings
Metallographic figure of Raw Metallographic figure of Shodhita
Swarna Makshika (M= 400X). Swarna Makshika (M= 400X).
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25. Initial Stride
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26. Marana
• Sukshmikaran (Fine powdering)
• Chakrika Nirmana (Pellet formation)- With other ingredients.
• Samputi Karana (Sealing in earthen vessels)
• Puta
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27. Intrinsic Worth
• Maximum Temperature range
• Duration of Maximum temperature
• Self Cooling
• Repetition of process
1. Hardness
2. Particle size
3. Chemical Constituents
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28. Vividness
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29. Explicitness
1200
1000
temperature
800
Temperature
600
(0C)
400
200
0
1 4 7 10 13 16 19
time in min. (1 = 15 units)
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30. Magnitude
 Conversion
 Potentiation
 Elimination
 Safety
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31. Makshika
SEM Feature of Raw S. M SEM Feature of Bhasma S. M
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32. Lauha Bhasma
Neetu Singh et al , Chemical Characterization of Lauha Bhasma by X-Ray Diffraction
and Vibrating Sample Magnetometry International Journal of Ayurvedic Medicine,
2010, 1(3), 143-149
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33. Rasa Sindoor
Transmission electron microscopy (TEM) images (a, b, and c) along with
selected area electron diffraction pattern (SAED) pattern (d) showing the
presence of sub-micron size, agglomerated, and crystalline particles in the drug
Rasa-Sindoor. S K Singh et al 2011 ,dept of Physics, BHU
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34. Rasa Sindoor
Scanning electron microscopy (SEM) image of the Rasa-Sindoor
showing the plate like porous surface morphology. Inset to the figure
shows the tiny voids presents in the material, S K Singh et al ,2011, Dept
of Physics ,BHU
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35. Miscellaneous
 Procurement  Packing
 Dispensing
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36. Recent Researches
Manufacturing
Characterization
Safety & Efficacy
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37. Observations
Scientific Approach Stakeholders
 Deptt of AYUSH,GOI
 Deptt of DST,GOI
 Academic Institutes
 Research Organizations
 ???????
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38. Characterizations
 IIT ,Rooraki
Kumar A
 IIT, Mumbai
Bellare Jayesh
 IIT ,Kharagpur
Roy Subrato
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39. Safety
 Schedule Y , D & C Rule
1945
 Rule 170 , D & C Rule
1945 – 24 Dec , 2008
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40. Rays of Radiance
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41. Selective Selection
Artificial Addition Inherent Innate
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42. Supervises Solubility
Developmental Doctrine Progressive Preferences
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43. Probable Postulation
Bio accumulation Bio detoxification
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44. Reductionist Relativity
Contour Conversion Eternal Endowment
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45. Procedural Principles
Blending Thermodynamics
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46. Assertive Assumptions
Visionary Validation Rational Realization
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47. Extended Elegance
Explanation Elucidation
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48. Prominent Paramount
Herculean Herbal Metamorphic Metal
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49. Absolve Absorption
Organic Order Actual Accomplishment
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50. Pragmatic Paradigms
Momentous Mercury Poise Parada
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51. Authentic Authenticity
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52. Bhasma as Nano-medicine
Global Guidance Crucial Clause
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53. Exceptional Embodiment

54. Stop Press
Additional GMP Additional Certification
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55. Enlighten Endorsement
Causative Consultation Comprehensive communication
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56. Special Submission
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57. Wisdomnary Vision
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58. Exigency in Education
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59. Take Home Message
Indian Inheritance Authoritative Agenda
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60. Conclusion
Ayurveda is Super Science!
Rasa Shastra is Super Chemistry!
All is Well
Dosage forms of Rasa Shastra & Bhaishjya
Kalpana - Super Pharmaceutics ?
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61. Acknowledgement
 Prof A Wele ,Head , Dept of Rasa Shastra,
College of Ayurveda, Bharati Vidyapeetha
,Pune
 All Team Rasa Shastra , BV ,Pune
 All Scholastic Scholars of Rasa Shastra at
Pune from 25/07/2011 to 30/07/2011
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62. Thanks & All Good Wishes ---
--
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