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Benign prostatic hyperplasia

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BPH- Pathology & Investigations
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Benign prostatic hyperplasia

  1. 1. VOIDING DISORDERS  Presented By:  Sukhpreet Kaur PPT-3
  2. 2. Function of Lower Urinary Tract  STORAGE of adequate volumes of urine at low pressure & with no leakage  EMPTYING that is  Voluntary  Efficient  Complete  Low pressure 5/8/2020 2
  3. 3. Anatomy of the Lower Urinary Tract  Bladder (detrusor)  Stores urine at low pressure  Compresses urine for voiding  Urethra  Conveys urine from bladder to outside world  Sphincter(s) internal & external  Controls urine flow & maintain continence between voidings 5/8/2020
  4. 4. ADULT VOINDING DYSFUNCTION 1.URINARY INCONTINENCE:-  Urinary incontinence means involuntary urination or leakage of urine. 5/8/2020 4
  5. 5. EPIDEMIOLOGY  More than 17 million adults in the united states are estimated to have urinary incontinence. 5/8/2020 5
  6. 6. RISK FACTORS  Pelvic muscle weakness  Age- related changes  Urinary disorders  High-impact exercise  stress 5/8/2020 6
  7. 7. TYPES  STRESS INCONTINENCE  URGE INCONTINENCE  REFLEX INCONTINENCE  OVERFLOW INCONTINENCE 5/8/2020 7
  8. 8. MANAGEMENT  Behavioral therapy  Pharmacologic therapy 5/8/2020 8
  9. 9. 2.URINARY RETENTION  Urinary retention is inability to empty the bladder completely during attempts to void. CAUSES:- Prostatic enlargement Pregnancy Infection Neurologic disorders 5/8/2020 9
  10. 10. 3.NEUROGENIC BLADDER  Neurologic bladder is a dysfunction that results from a lesion of the nervous system.  CAUSES  Spinal injury  Multiple sclerosis 5/8/2020 10
  11. 11. 5/8/2020 11 Benign Prostatic Hyperplasia  Generalised disease of the prostate due to hormonal derangement which leads to enlargement of the gland .
  12. 12. INCIDENCES  Occurs in 50% of men over 50 and in 80% of men over 80 have BPH.  Many men with BPH may have mild symptoms and may never need treatment.  In India total no patients 1,696,347. 5/8/2020 12
  13. 13. BPH Etiologies  Cause not completely understood  Change in hormonal with alterations in the testosterone/estrogen balance  Induction of prostatic growth factors  Increased stem cells  Accumulation of dihydroxytestosterone.
  14. 14. 5/8/2020 14 Benign Prostatic Hyperplasia
  15. 15. BPH Pathophysiology Normal BPH Hypertrophied detrusor muscle Obstructed urinary flow PROSTATE BLADDER URETHRA Kirby RS et al. Benign prostatic hyperplasia. Health Press, 1995.
  16. 16. BPH Pathophysiology  Slow and insidious changes over time  Complex interactions between prostatic urethral resistance, intravesical pressure, detrussor functionality, neurologic integrity, and general physical health.  Initial hypertrophydetrussor decompensation poor tonediverticula formationincreasing urine volumehydronephrosisupper tract dysfunction
  17. 17. 5/8/2020 17 Clinical manifestations  Voiding symptoms  decrease in the urinary stream  Dribbling at the end of urination  Hesitancy  Pain or burning during urination  Feeling of incomplete bladder emptying
  18. 18. 5/8/2020 18 Clinical manifestations  Irritative symptoms urinary frequency dysuria bladder pain nocturia incontinence symptoms associated with infection
  19. 19. 5/8/2020 19 Diagnostic Tests  History & Examination  Digital rectal exam (DRE)  Urinalysis  Urine culture  BUN  Prostate specific antigen (PSA)  Transrectal ultrasound – biopsy  Uroflometry
  20. 20. 5/8/2020 20 DRE
  21. 21. MANAGEMENT OF BPH 5/8/2020 22
  22. 22. MANAGEMENT OF BPH  Catheterization (stylet)  Watchful waiting and behavioral modification  Medical Management  Alpha blockers  5-alpha reductase inhibitors  Combination therapy  Surgical Management  Urethral stents
  23. 23. Watchful Waiting and Behavioral Modification  “is the preferred management technique in patients with mild symptoms.  AUA score < 7,
  24. 24. Watchful Waiting and Behavioral Modification  Decrease caffeine, alcohol )diuretic effect(  Avoid taking large amounts of fluid over a short period of time  Void whenever the urge is present, every 2-3 hours  Maintain normal fluid intake, do not restrict fluid  Avoid bladder irritants to include dairy products, artificial sweeteners, carbonated beverages  Limit nighttime fluid consumption  BPH symptoms can be variable, intermittent
  25. 25. 5/8/2020 26 Medical Management Alpha adrenergic receptor blockers  promote smooth muscle relaxation in the prostate  Relaxation of the muscles facilitates urinary flow  Doxazosin (Cardura), Terazosin (Hytrin), Tamsulosin (Flomax), Alfuzosin (Uroxatral)
  26. 26. 5/8/2020 27 Medical Management 5 alpha reductase inhibitor )finasteride : Proscar(  Reduce size of prostate gland by up to 30 %  Blocks the enzyme of 5 alpha reductase which is necessary to stop the conversion of testosterone to dihydroxytestostersone
  27. 27. Combination Therapy  Concomitant use of alpha blockers and 5-alpha reductase inhibitors  Should be reserved for patients who are at significant risk of progression and adverse outcome  Poor surgical candidate  Patient wants to avoid surgery  Significant cost associated with dual medications
  28. 28. 5/8/2020 29 Medical Management  Herbal therapy – saw palmetto fruit – use to improve urinary symptoms and urinary flow  Problem with herbal therapy – long term effectiveness
  29. 29. surgical treatment
  30. 30. Surgical Management  Minimally Invasive techniques  1. Transurethral Microwave thermotherapy  2.Transurethral needle ablation.
  31. 31. Surgical Management  Open simple prostatectomy  TURP (Transurethral Prostatectomy)  Transurethral incision of the prostate  Laser Prostatectomy
  32. 32. TURP “Gold Standard” of care for BPH
  33. 33. NURSING MANAGEMENT 5/8/2020 34
  34. 34. 5/8/2020 35 Preoperative care  Antibiotics  Allow pt to discuss concerns about surgery on sexual functioning  Prostatic surgery may result in retrograde ejaculation
  35. 35. 5/8/2020 36 Postoperative Goals  No complications  Restoration of urinary control  Complete bladder emptying
  36. 36. 5/8/2020 37 Postoperative Care  Monitoring  Continuous irrigation & maintain catheter patency  Blood clots and hematuria are expected for the first 24-36 hours  After catheter is removed – check for urinary retention and urinary stream
  37. 37. 5/8/2020 38 Discharge planning  Catheter care  Managing urinary incontinence  Oral fluid intake – 2,000-3,000 cc per day  Observe for s/s of urinary tract infection  Prevent constipation  Avoid lifting  No driving or intercourse after surgery
  38. 38. BPH TREATMENT New Modalities  Minimally invasive: (Prostatic Stents,TUNA,TUMT, HIFU,Water- induced Thermotherapy)  Laser prostatectomy (VLAP,ILC,CLAP,TULIP,HoLRP)  Electrovaporization (TUVP,TVRP)
  39. 39. summary 5/8/2020 40

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