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What conditions does hydrogen therapy have a positive effect on?
Project The current conclusion of the subject
Eye, Ear, And Dental Disease
Ischemia Retinae Reperfusion
Inhaled H2 significantly reduced the damage to the retinal cells, while significantly
reducing both 4-HNE and pediatric L1-and TNF-a levels. Inhalation can exert its
neuroprotective effects through the antioxidant, antiinflammatory, and antiapoptotic
pathways
Retinal Damage Hydrogen-rich water improves light-induced retinal damage in rats
Optic Nerve Clip
Experimental study of the protective effect of saturated hydrogen water on retinal
ganglion cells in rat optic nerve clip model
Amphiblestritis
Inhalation can exert its neuroprotective effects through the antioxidant, antiinflammatory,
and antiapoptotic pathways
Rhinallergosis Hydrogen absorption can improve the symptoms of allergic rhinitis in rats

2. Cataract
The lens opacity degree of the model group was significantly enhanced compared with the
control group, while the hydrogen water treatment reduced the lens opacity degree
compared with the model group. Hydrogen water enhances the antioxidant enzyme
activity while decreasing the MDA levels.
Glaucomatous Ocular Hypertension
Hydrogen absorption can reduce the visual degeneration caused by high intraocular
pressure
Uveitis
Hydrogen absorption inhibited the elevated AqH protein, and reduced microglial
activation, and ameliorated uveitis eye disease
Retinosis
The intervention with high concentration of hydrogen works well on MNU-induced retinal
degeneration in mice
Retinal Vein Obstruction High concentrations of hydrogen worked well in rats with retinal vein occlusion
Explosive Deafness
Hydrogen absorption can significantly improve the hearing loss caused by blast sound
waves
Sudden Deafness Hydrogen absorption can significantly reduce hearing loss in sudden deafness
Deafness Noise Establishment and protection of recessive hearing loss
Noise Deaf
Hydrogen absorption significantly improves noise-induced hearing loss and is closely
related to NRF2 expression in hair cells
Allergic Rhinitis Relief of allergic rhinitis in mice with high concentrations of hydrogen
Paradentitis
In the experimental group, the tooth loosening, gingival index and alveolar bone loss
values were significantly reduced compared with the positive control group, the
pathological atrophy and erosion of the sulcal epithelium was reduced, the exudation of
inflammatory cells in the periodontal tissue was less, and less osteoclasts were formed in
the alveolar bone.
Endocrine And Metabolic Diseases
Osteoporosis
Hydrogen inhalation can regulate the balance of osteoblasts and osteoclasts through
RANKL pathway and prevent osteoporosis after menopause

3. Cholesterol Metabolism
Molecular mechanisms of molecular hydrogen in regulating inflammatory polarization of
macrophages and cholesterol metabolism transport
Chronic Inflammation And Aging
Effects of hydrogen inhalation on the chronic inflammation and aging of nematodes (or
mice)
Diabetes Mellitus Hydrogen absorption helps to lower blood sugar and relieve insulin resistance
Cisplatin Kidney Injury
Hydrogen gas can effectively alleviate the nephrotoxicity caused by high concentration of
cisplatin and reduce cell apoptosis
Type 1 Diabetes
Hydrogen promotes glucose uptake through the glucose transporter 4, and hydrogen
significantly enhances the expression of the membrane glucose transporter 4 in the
skeletal muscle cells of type 1 diabetic mice, and significantly promotes ascending insulin
regulation.
Tumour
Dermoid Tumor
Inhalation of high concentration of hydrogen significantly inhibited the growth of rat
ovarian teratoma
Hydrogen Protection In Colon Cancer And
Oesophageal Cancer Tumors
Inhalation of high concentration of hydrogen has an obvious inhibitory effect on tumor
proliferation and metastasis
Carcinoma Of The Lungs Hydrogen gas inhibits the metastasis of lung cancer cells
Cancer Of The Liver
Inhalation of high concentration of hydrogen has a significant inhibitory effect on rat liver
cancer
Gliocytoma Inhalation of a high concentration of hydrogen has an obvious inhibitory effect on glioma
Oophoroma There is a large database analysis of the transcriptome and proteome of cancer cells
The A549 Cell Line Was Used
Inhalation of high concentration of hydrogen has a significant inhibitory effect on rat liver
cancer
Carcinoma Of The Lungs Hydrogen inhibits tumor growth by inhibiting the cell cycle of lung cancer cells
Angiocardiopathy

4. Ischemia Myocardial Hydrogen absorption has a protective effect against myocardial injury. The expression of
the downstream target genes was regulated by biochemical, histological,
immunohistological, and immunohistochemical assays, and via the IP3K, / AKt1 signaling
pathway
Reperfusion Injury
Pulmonary Hypertension
The protective effect of hydrogen and water as an antioxidant on pulmonary hypertension
Hydrogen because of its antioxidant activity can reduce the lung inflammatory response,
thus having a protective effect.
Myocardial Hypertrophy Hydrogen absorption reduces cardiac hypertrophy
Atherosclerosis Hydrogen absorption inhibits spontaneous atherogenesis in rats
Vascular Protection Vascular protection effect of Hydrogen gas (H2) and its research progress
Aging Heart And Kidney Injury
Hydrogen-containing water relieves aging-related heart-kidney injury in salt-sensitive rats
The common water group showed a progressive increase in blood pressure, increased
urinary albumin content, enhanced cardiac reconstruction, and significant pathological
changes at 48 weeks, such as glomerular sclerosis and renal tubular fibrosis, cardiac
myocyte hypertrophy, and interstitial fibrosis. These pathological changes are associated
with enhanced inflammation and oxidative stress in the organs. Hydrogen water can
reduce the level of inflammation and oxidative stress, and reduce the pathological
changes.
Aneurism
Effect of hydrogen-saturated saline on residual stress in the aorta of rats with abdominal
aortic aneurysm
At 28 d after the modeling, the abdominal aorta diameter in both the experimental group
and the control group increased significantly compared with the preoperative patients; and
the expansion rate was significantly lower than that in the control group. The open Angle
of the abdominal aorta was significantly greater than that of the control group, while the
vessel wall thickness was significantly less than that of the control group. Histological
observation showed that there were a few inflammatory cells in the aortic wall, while the
aortic wall was not significantly damaged, and the elastic fibers were significantly
damaged.

5. Cardiac Ischemia And Reperfusion
Inhalation of nitric oxide or hydrogen alone reduces the size of myocardial infarction, and
the combination has an enhanced effect, and can reduce reactive oxygen species and
neutrophil infiltration, and improve heart function.
Disease Of Respiratory System
Asthma
Hydrogen absorption improves airway resistance, and MDA (lipid hyperhydride) is
significantly reduced in the division tissue. Hydrogen absorption reduces airway
inflammation and improves large M lung function
Acute Lung Injury
Protective effect of hydrogen-rich normal saline on acute lung injury in rats caused by
smoke inhalation
Being Poisoned By Agricultural Chemicals
survival rate, SOD, MDA, MPO, LDH, liver and kidney function indicators. Hydrogen
absorption can slow down injuries caused by pesticide poisoning
Lps, Injury Of Lungs
Hydrogen absorption can reduce the slash mortality of acute lung injury in LPS and
reduce the inflammatory response
Pulmonary Fibrosis
Hydrogen absorption does not improve the degree of fibrosis caused by Berlin (once a
day)
Organ Mucus Increases From Smoking
Hydrogen-rich saline relieved the increased tracheal mucus induced by smoking in rats
Pretreatment with hydrogen-rich water alleviated bronchial mucus accumulation caused
by cigarette exposure, endotracheal epithelial goblet cell hyperplasia, muc5ac
overexpression, and abnormal cell apoptosis, and increased MDA levels in
bronchoalveolar lavage fluid. Hydrogen-rich water also inhibited Tyr phosphorylation at
EGFR1068 and elevated Nrf2 expression in the lung caused by cigarette exposure
COPD
Hydrogen inhalation improves COPD pulmonary function, pulmonary pathology, and
cardiovascular function o reduces the inflammatory response through the lowering of
TNF-a, IL-6, IL-17, IL-23, MMP-12, TIMP-l, caspase-3., and caspase-8 expression levels
PAH
Hydrogen gas intervention plays a certain role in preventing pulmonary hypertension by
reducing the right ventricular systolic blood pressure, the right heart hypertrophy index,
and the degree of remodeling of small pulmonary vessels

6. Carcinoma Of The Lungs
Hydrogen absorption can significantly reduce the growth and propagation of implant
swelling and pain cells
Organic Moraine Poisoning
Hydrogen absorption improves the respiratory circulation disorders caused by
organophosphorus poisoning
Pneumoconiosis
Hydrogen absorption can improve lung function and reduce inflammatory response in
pneumoconiosis rats
In Vitro Studies Of Lung Cancer Hydrogen inhibits the painful cell growth of lung cancer swelling in vitro
Chronic Fibrous Pneumonia Intervention study of hydrogen inhalation therapy on master fibrosis in rats
Radiation Pneumonitis
Hydrogen gas is able to reduce the inflammatory response of radiation-induced
pneumonia
Lung Injury, Pulmonary Arterial Hypertension
Hydrogen intervention occurs by reducing right ventricular systolic blood pressure, right
heart hypertrophy index, and pulmonary small vessel remodeling Degree, so that
pulmonary hypertension plays a certain preventive role
Effect Of Hydrogen On Pulmonary
Microvascular Endothelial Dysfunction In Lps
Hydrogen significantly relieved the endothelial injury induced by LPS
Severe Asthma Mice Macrophage Endocytosis
Function
High concentrations of hydrogen enhance the function of alveolar macrophages to
swallow phagocytic bacteria
Phagocytosis Function Of Alveolar Macroonly
Cells After Cigarette Stimulation
High concentrations of hydrogen can repair damaged lung epithelial cells and enhance the
function of alveolar macromile cells
Transplant The Lung
The mechanism of hydrogen improving lung compliance based on the change of lung
surfactant
Respiratory Disorder During Sleep
Hydrogen absorption on significant relief of sleep disordered breathing caused by
intermittent low hydrogen (cardiovascular)
Respiratory Disorder During Sleep
Hydrogen absorption has significant relief of sleep breathing caused by intermittent low
hydrogen (brain)
Agenesis Of Lung Effect of hydrogen inhalation on respiratory system development in preterm rats

7. Acute Lung Injury
Inhaled hydrogen helps to alleviate acute lung injury and reduce inflammatory factor
levels in mice
Septic Shock
Effect of fluid resuscitation combined with hydrogen inhalation on the lungs of rats with
septic shock
Comparing the fluid resuscitation group and the hydrogen inhalation group with the
simple fluid resuscitation group, the level of pro-inflammatory mediators in the
bronchoalveolar lavage fluid was significantly reduced, and the Fas expression and Bcl-2
expression were significantly decreased
Hyperbaric Lung Injury Hydrogen inhibits hyperbaric oxygen lung injury through the Nrf2 pathway
Liver Disease Therapy
Hepatic Ischemia Hydrogen absorption significantly improved liver function, decreased serum inflammatory
cytokines, induced the activation of the PI3K-Akt pathway, and inhibited hepatocyte
apoptosis
Reperfusion Injury
Hepatic Fibrosis
Oral hydrogen water can significantly inhibit the liver fibrosis caused by the inducer.
Isolating hepatocytes, hydrogen-rich medium can selectively inhibit the generation of
hydroxyl radicals and hepatocyte cell death.
Alcoholic Liver Injury Protective effect of hydrogen saline on alcoholic liver injury in rats
Lung Transplantation
Hydrogen has a protective effect on lung transplantation through the anti-inflammatory,
antioxidant, and anti-apoptotic mechanisms.
Urology And Reproductive System Diseases
Rhabdomyolysis And Acute Kidney Injury
Hydrogen-rich water pretreatment reduces glycerol-induced rhabdomyolysis and acute
kidney injury
Eclampsia
Protective effect of hydrogen-rich saline in preeclampsia rats
After the hydrogen-rich saline treatment, the rat blood pressure did not change
significantly; the urinary protein content and the serum VEGF content increased
significantly in the hydrogen-rich saline group.

8. Hepatitis
Effects of hydrogen-rich water on oxidative stress level, liver function and viral load in
patients with chronic hepatitis B
Compared with normal, hepatitis B patients obvious oxidative stress response, and liver
function is seriously impaired. After hydrogen water treatment, oxidative stress improved
significantly, but no significant difference in liver function and HBV DNA levels.
Kidney Stone
Hydrogen absorption can reduce the kidney damage caused by stones. Successfully
reduced the MAD,
8 – 0HdG performance, elevated antioxidant SOD, GSH and CAT expression.same
It uated OPN, CD44 and MCP-1, but upregulated IL-10 expression
Endometria
Respiratory hydrogen can improve the performance of SOD, CAT and GSH in blood and
tissues
Ectopic Disease
Low MMP-9 and COX-2 performance. Hydrobiogenic group ectopic inner membrane
grows slowly or
Without growth, prostacyclin secretion expression was significantly reduced, pain was
reduced, and blood vessels were reduced
Expression of other growth factors were significantly reduced
Kidney Ischemia-Reperfusion Injury
Treatment effect of hydrogen gas on ischemia-reperfusion injury in rat kidney
Hydrogen can significantly ameliorate the early and late renal injury caused by ischemia
and reperfusion.
Kidney Aging
Effects of saturated hydrogen-salt solution on renal aging in aged rats
Compared with the adult group, SOD activity, propylene dehyde and 8-OHdG, SOD, and
8-OHdG. Compared with the adult group, both p35 and p16 mRNA, SIRT1, p35 and p16
mRNA and SIRT1 in the older age group.
Ovariotomy Hydrogen water prevents osteopenia in ooptomized rats

9. Hydrogen water has no significant effect on estradiol production in ovariectomized rats,
but it can prevent reduced bone mass, including femoral and vertebral bone mineral
content and bone mineral density, and can maintain bone strength (including maximum
load, hardness, energy) and bone structure. In addition, hydrogen water can inhibit
oxidative stress and the expression of IL-6 and TNFα mRNA in ovaritomized rats; it can
enhance endothelial nitric oxide synthase activity to increase circulating nitric oxide
levels.
Digestive System Disease
Injury Of Small Intestine
Respiratory hydrogen reduced the necrotic area of the small intestine, and by HE staining
and the inflammatory factor IL-1, the TL-6 detection was found to reduce the small
intestinal mucosal edema and inflammatory response
Peritoneal Adhesion Sated hydrogen water reduced postoperative adhesion caused by cecal abrasions in rats
Nec
Protective effects of hydrogen-rich saline against necrotizing enterocolitis in neonatal rats
Hydrogen-rich water can maintain the animal body weight, reduce the incidence of
necrotizing enterocolitis, improve the animal survival rate, and can reduce the disease
level. Hydrogen water can also inhibit the expression of pro-inflammatory mediators,
reduce lipid peroxidation, and enhance the antioxidant capacity. However, hydrogen water
had no effect on interleukin-10 expression.
Cancer Of Colon
Hydrogen absorption enables significantly less colorectal cancer tumor formation and
development
Pancreatitis Hydrogen absorption can improve the pancreatitis mortality rate
Intestinal Injury
Effect of hydrogen-rich saline on intestinal injury in rats with delayed resuscitation of
severe scald
Compared with the normal saline group, the intestinal pathology was significantly reduced
at 24 and 48 h, the diamine oxidase was significantly increased, and the apoptosis rate of
interleukin 1 and intestinal mucosal epithelial cells was significantly decreased.

10. Acute Pancreatitis Effect of hydrogen-rich normal saline on acute pancreatitis in rats
Hydrogen water reduced the plasma inflammatory factors level and the pancreatic
histopathology score, reduced the MDA level and the myeloperoxidase activity, and
increased the SOD and GSH. Hydrogen water reduced both pancreatic TNF and ICAM-1
mRNA levels.
Metastasizing Septicemia
Hydrogen gas is effective in improving the mortality rate from sepsis and reducing the
inflammatory response
Septic Blood Blood Intestinal Injury
Effect of hydrogen-rich fluid on intestinal injury in septic rats
Compared with the sham group, TNF-, IL-6, HMGB1 and MDA, SOD and GSH-PX,
IL-6, HMGB1 and MDA, SOD and GSH-PX, and the injury was reduced.
Colitis Gravis
Protective effects of hydrogen-rich water on ulcerative colitis in rats
Animals in the model group developed symptoms of acute ulcerative colitis, including
diarrhea, weight loss, and colonic mucosal injury. Hydrogen water can relieve these
symptoms. In addition, hydrogen water can also inhibit the elevated expression of
vascular endothelial growth factor.
Gastric Mucosal Injury Protective effects of hydrogen-rich water on aspirin-induced gastric mucosal injury in rats
Spinal Cord And Neurological Diseases
Cerebral Ischemia Reperfusion
Effect of hydrogen-rich fluid on the mitochondrial permeability switch pore and cell
apoptosis in the hippocampus after cerebral ischemia / reperfusion injury in rats
Hydrogen-rich solution can effectively reduce the whole brain ischemia and reperfusion
injury and reduce Cyt C translocation to the cytosol, thus inhibiting cell apoptosis after
brain ischemia and reperfusion in rats, and the mechanism is related to the inhibition of
mPTP opening in hippocampal cells.
Cerebral Ischemia Reperfusion
Effect of hydrogen-rich fluid on the mitochondrial permeability conversion pore in rats
with focal cerebral ischemia-reperfusion injury
Alzheimer'S Disease, Senile Dementia
Effect of hydrogen-saturated saline on oxidative stress injury in Alzheimer's disease
model rats

11. Cerebral Ischemia Reperfusion
Maternal hydrogen intake attenuated fetal mouse hippocampal damage induced by uterine
ischemia and reperfusion
Bowel Ischemia And Reperfusion In The Brain
Injury
Compared with the sham group, the normal neurons count, incubation period and
swimming distance in prefrontal cortex of model group and hydrogen group decreased,
decreased platform crossing time, increased brain water content, and increased apoptotic
neurons, and increased normal neurons count, decreased latency and swimming distance,
decreased brain water content, and decreased apoptotic neurons. Brain histopathological
damage was evident in the model group and significantly decreased in the hydrogen
group.
Cognitive Impairment Caused By Cerebral
Ischemia
Hydrogen gas relieves the cognitive impairment induced by transient cerebral ischemia by
inhibiting oxidative stress
Inhalation of hydrogen can significantly reduce the latency of ischemic rats and
significantly prolong the residence time in the target quadrant. Hydrogen significantly
increases the neuronal density in the CA1 region of ischemic rats, and hydrogen can also
inhibit the increase of MDA levels in the brain caused by ischemia, and restore the SOD
and catalase activity to normal
Gliosis Caused By Spinal Cord Injury Molecular hydrogen inhibits oxidative damage-related astrogliosis in SCI in rats
Brain Injury Caused By Subarachnoid
Hemorrhage
Hydrogen water may play a neuroprotective role on the nervous system injury and
apoptosis after subarachnoid hemorrhage by regulating the Akt / GSK3β signaling
pathway
The Spinal Cord Neuron Injury
Protective effects of molecular hydrogen on rat spinal neurons of H2O2 induced oxidative
injury in vitro
Behavioral Deficiency
Hydrogen can significantly reduce the neural apoptosis and oxidative stress caused by
sevoflurane exposure, and hydrogen can alleviate the impaired adult long-term memory
and the social behavior abnormalities caused by sevoflurane exposure in neonatal mice.

12. Sudden Cardiac Arrest
Injection of hydrogen water can improve the 72-hour survival rate and neurological score,
and reduce nerve damage and neuronal apoptosis. Hydrogen water can reduce the
oxidative stress index and enhance the antioxidant enzyme activity in blood and
hippocampus.
Cerebral Injury
After 24 hours and 72 hours, animals showed impaired blood-brain barrier, brain edema,
neurological defects and Lyn kinase phosphorylation and trypsin, indicating that mast cell
activation, hydrogen can reduce Lyn kinase phosphorylation and trypsin release, reduce
mast cell aggregation and degranulation, alleviate impaired blood and brain barrier,
improve the neurobehavioral function.
Neurovascular Dysfunction
Hydrogen gas can alleviate the neurovascular dysfunction induced by hypoxia or
ischemia, and thus has a neuroprotective effect.
Agitans Paralysis Hydrogen water can significantly improve the PD patient scale score.
Inflammation, Allergies, Radiation, Skin And Other Diseases
Rheumatic Arthritis
Interleukin 6, an inflammatory index in the blood, decreased by 37.3 ± 62.0% at 4 weeks
after treatment, and the study found that injecting hydrogen normal saline was safe and
effective in treating human rheumatoid arthritis.
Pyemia
Hydrogen-rich water significantly decreased the plasma levels of HMGB, alanine
aminotransferase, creatinine and blood urea nitrogen, pulmonary interleukin 6, HMGB,
nitric oxide and MDA levels, and lung wet-to-dry weight ratio and histological score,
which enhanced the SOD activity.
Oxidative Stress And Antioxidant Levels
Running exercise significantly increased the oxidative stress and antioxidant levels in
horses, and hydrogen water has antioxidant effect.
Infectious Shock
The combination of early fluid resuscitation and hydrogen inhalation can protect the lungs
and intestines of septic shock rats from oxidative stress and inflammatory response
damage.
Cardiopulmonary Bypass Hydrogen inhibits inflammatory responses in a cardiopulmonary bypass rat model
Aplastic Anemia Treatment effect of hydrogen-rich water on aplastic anemia

13. Hydrogen water can promote the recovery of blood and immune function in aplastic
anemia animals.
Ionizing Radiation Damage
Effect of intraperitoneal injection of hydrogen saline on cochlear injury induced by
ionizing radiation in guinea pigs
The ABR threshold value at 8 days after irradiation was lower than that of the irradiation
group; the ABR threshold value of 8 days after the hydrogen plus irradiation group and
the irradiation group was increased compared with the 4 days before medication. Eight
days after irradiation, the MDA of the hydrogen plus irradiation group was lower than the
irradiation group, the SOD content was higher than the irradiation group, and the helger
tissue structure of the hydrogen plus irradiation group was better than the irradiation
group.
Pressure Ulcer (Bedsores)
Effect of hydrogen water on pressure ulcer patients and the reconstruction of normal skin
cells in vitro
Pressure Sores
Hydrogen respiration can significantly reduce the pressure ulcer skin lesions group by the
activation of the Nrf2 pathway
The levels of reactive oxygen radicals in vascular endothelial cells, in Fig
To enhance the expression level of its antioxidant reductase
Melanoma
Hydrogen gas can effectively reduce the level of oxidative damage in human skin cells
and relieve the oxidation
Stress impaired melanocyte proliferation, migration, apoptosis and melanogenic activity
Injury level, with the potential clinical intervention effect of vitiligo, and its protective
effect
Closely related to its regulatory role on the Nrf2 and Wnt / Bcatenin pathways
White Madness Hydrogen gas can effectively reduce the level of oxidative damage in human skin cells
Skin Ischemia-Reperfusion Injury
Protective effects of hydrogen-rich water on ischemia-reperfusion injury in rat skin
plaques

14. Hydrogen water significantly improved the skin survival and blood perfusion in the
ischemic sites compared with the control group, significantly reduced the generation of
lipid peroxidation marker MDA, and hydrogen water suppressed the increased
inflammatory cytokines, chemokines and growth factors. Hydrogen water can also reduce
the inflammatory cell infiltration induced by ischemia-reperfusion.
Allergic Dermatitis
Effect of hydrogen water on allergic dermatitis
Hydrogen water significantly reduced the plasma levels of IL-10, TNF-, IL-12p70, and
GM-CSF in the animals when compared with the control animals. Hydrogen water may
regulate allergic dermatitis by regulating the Th1 and Th2 balance.
The Uvb-Mediated Skin Damage
Effect of hydrogen-electrolysis water bath treatment on UV-mediated skin damage
Electrolytic water bathing can reduce the skin damage and inflammatory factor levels
caused by UVB radiation, and has a protective effect on UVB-induced cell damage.
Others (Cytological Studies, Reviews)
Cell Trauma
Hydrogen can alleviate TNF-induced osteoblast damage by inhibiting oxidative stress,
protecting mitochondrial function, inhibiting inflammation, and improving NO
bioavailability.
In Vitro Studies Of Tumors Hydrogen inhibits tumor cell growth of lung cancer in vitro
Fatty Acid Uptake, And Lipid Deposition
Hydrogen pretreatment reduced the fatty acid uptake and lipid deposition by hepatocytes
upon soft-quality acid excess, which is associated with the inhibition of JNK activation.
Hydrogen treatment had no effect on the CD36 mRNA expression level, but could reduce
its protein expression.
Drug Addiction
Hydrogen absorption can significantly improve the death of mice caused by a medium
dose of METH
In other drugs
Pulmonary Alveolar Epithelial Cell Damage
Caused By Hyperbaric Oxygen
Protective effect of hydrogen on alveolar epithelial cell injury