Uremic Bleeding

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This document summarizes evidence-based treatment recommendations for uremic bleeding. Uremic bleeding is a complication of renal failure caused by multiple factors including dysfunctional von Willebrand factor, accumulation of uremic toxins, anemia, and platelet dysfunction. Treatment options aim to address specific pathophysiological mechanisms and may include erythropoietin to increase red blood cell count, cryoprecipitate to provide clotting factors, desmopressin to release von Willebrand factor and factor VIII, and estrogens to decrease nitric oxide levels and increase platelet aggregation. Early prevention and treatment that targets multiple disease mechanisms may most effectively manage uremic bleeding.

Health & Medicine Technology

09/05/11 Laboratory Services and Consultations Limited Presents Case Review 27 th August 2011 Susan Forde

09/05/11 Evidence-Based Treatment Recommendations for Uremic Bleeding

Normal Hemostatic Mechanisms ,[object Object],09/05/11

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Pathophysiology ,[object Object],09/05/11

Von Willebrand Factor ,[object Object],[object Object],09/05/11

Anemia ,[object Object],[object Object],09/05/11

Prevention by Dialysis ,[object Object],09/05/11

Erythropoietin ,[object Object],09/05/11

Cryoprecipitate ,[object Object],09/05/11

MECHANISMS OF ACTION OF DESMOPRESSIN ,[object Object],09/05/11

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