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Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.

Cell Therapy Expansion and Challenges in Autoimmune Disease

Health Advances

There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities. In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions. Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved. Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.

Role of Mukta Pishti in the Management of Hyperthyroidism

Dr. Jyothirmai Paindla

CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1

rishi2789

The Electrocardiogram - Physiologic Principles

MedicoseAcademics

These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram. Learning objectives: 1. Define an electrocardiogram (ECG) and electrocardiography 2. Describe how dipoles generated by the heart produce the waveforms of the ECG 3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II) 4. Differentiate between intervals and segments 5. Enlist some common indications for obtaining an ECG 6. Describe the flow of current around the heart during the cardiac cycle 7. Discuss the placement and polarity of the leads of electrocardiograph 8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained 9. Define mean electrical vector (axis) of the heart and give the normal range 10. Define the mean QRS vector 11. Describe the axes of leads (hexagonal reference system) 12. Comprehend the vectorial analysis of the normal ECG 13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation 14. Explain the concepts of current of injury, J point, and their significance Study Resources: 1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition 2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition 3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition 4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/ 5. ECG in Medical Practice by ABM Abdullah, 4th edition 6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/ 7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics

CHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdf

rishi2789

Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx

Dr. Rabia Inam Gandapore

Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...

Oleg Kshivets

Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).

CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf

rishi2789

OCT Training Course for clinical practice Part 1

KafrELShiekh University

Does Over-Masturbation Contribute to Chronic Prostatitis.pptx

walterHu5

Hemodialysis: Chapter 5, Dialyzers Overview - Dr.Gawad

NephroTube - Dr.Gawad

- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ - Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0 - Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html - Link to NephroTube website: www.NephroTube.com - Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html

Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx

Dr. Rabia Inam Gandapore

Clinic ^%[+27633867063*Abortion Pills For Sale In Tembisa Central

19various

REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx

LaniyaNasrink

Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad

NephroTube - Dr.Gawad

- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0 - Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc - Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html - Link to NephroTube website: www.NephroTube.com - Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html

Hiranandani Hospital Powai News [Read Now].pdf

Dr. Sujit Chatterjee CEO Hiranandani Hospital

Hiranandani Hospital in Powai, Mumbai, is a premier healthcare institution that has been serving the community with exceptional medical care since its establishment. As a part of the renowned Hiranandani Group, the hospital is committed to delivering world-class healthcare services across a wide range of specialties, including kidney transplantation. With its state-of-the-art facilities, advanced medical technology, and a team of highly skilled healthcare professionals, Hiranandani Hospital has earned a reputation as a trusted name in the healthcare industry. The hospital's patient-centric approach, coupled with its focus on innovation and excellence, ensures that patients receive the highest standard of care in a compassionate and supportive environment.

The Nervous and Chemical Regulation of Respiration

MedicoseAcademics

These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration: Learning objectives: 1. Describe the organisation of respiratory center 2. Describe the nervous control of inspiration and respiratory rhythm 3. Describe the functions of the dorsal and respiratory groups of neurons 4. Describe the influences of the Pneumotaxic and Apneustic centers 5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration 6. Explain the role of central chemoreceptors in regulation of respiration 7. Explain the role of peripheral chemoreceptors in regulation of respiration 8. Explain the regulation of respiration during exercise 9. Integrate the respiratory regulatory mechanisms 10. Describe the Cheyne-Stokes breathing Study Resources: 1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition 2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition 3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition

Learn About Things We Do That Our Felines Hate

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