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Pharmacology

Pain Management
Pain Management
• Analgesics relieve pain without producing loss of
  consciousness or reflex activity
• Should be potent
• Should not cause dependence
• Should exhibit little adverse effects: constipation,
  hallucinations, respiratory depression, N/V
• Should not cause tolerance
• Should act promptly 7 over a long period w/little
  amount of sedation
Pain Management
•   Classifications:
•   Opioid Agonist
•   Partial Opioid Agonist
•   Opioid Antagonists
•   Salicylates
•   NSAIDs
•   Misc. Analgesic Agents
Pain Actions
• Pathways to pain tranasmission from the site
  of injury to the brain for processing & reflexive
  action
• First step:
• Nociceptors
  – Transduction
  – Transmission
  – Perception
  – modulation
Pain Action
• Nociceptor
  – Stimulation of receptors at nerve endings (skin,
    blood vessel, joints, SQ, periosteum, viscera)
  – Classified—thermal, chemical, mechanical-
    thermal based on type of sensation they transmit
Pain Actions
• Important to Nociceptors is the transduction
  phase for meds to causing their effects
• Transduction
  – 1. noxious stimuli causes cell damage with release of
    sensitizing chemicals
     •   Prostaglandins
     •   Bradykinin
     •   Serotonin
     •   Substance P
     •   Histamine
  – 2. these substances activate nociception and lead to
    generation of action potential
Pain Actions
• Neurotransmitters role in tranmission of nerve
  impulses
• Somatostatin
• Cholecystokinin
• Substance P
Pain Actions
• In the CNS there are 4 pain-transmitting
  pathways to various areas of the brain for
  response—opiate receptors
  – Mu—induce central analgesia, euphoria, dependence,
    miosis, resp. depression
  – Delta—limbic for euphoria
  – Kappa—responsible for analgesia, sedation, dysphoria
  – Epsilon-
  – Sigma (opioid & partial agonists)—autonomic
    stimulation, hallucinations, sysphoria
Pain Actions
•   Blocking chemicals:
•   Histamine
•   Prostaglandins
•   Serotonin
•   Leukotrienes
•   Substance P
•   Bradykinin
•   Antihistamines—benadryl,
•   Prostglandins Inhibitors—NSAIDs
•   Substance P Antagonists—capsaicin
•   Antidepressants—prolong norepinephrine and serotonin-
    TCA, SSRI
Pain Actions
• Adjunct Agents
• Adrenergic
    – Norepinephrine
    – Clonidine
• GABA Receptor Stimulants—block nociceptor activity
• Baclofen
• Gabapentin
• Valproic Acid--block trigeminal neuralgia
• Phenytoin
• Gabapentin
• Caarbamazepine
• TCA—inhibit reuptake of serotonin & norepinephrine causing rapid
  anagelsia
• Bisphosphonate—pamidronate effective treating bony metastases
Pain Stepwise Approach
1. Non-opioid +/- Adjuvant—pain persisting or
   increasing
2. Opioid for mild to moderate pain—pain
   persisting or increasing
      +/- Non-opioid
      +/-Adjuvant
3. Opioid for moderate to severe pain
     Non-opioid
     +/- Adjuvant
Pain Recommendations
• Mild acute pain—ASA, NSAIDs, or Tylenol
• Inflammatory pain—NSAIDs
• Unrelieved moderate pain—moderate potency—
  codeine or oxycodone often combination
  w/Tylenol or ASA
• Severe acute pain—opioid agonist-Morphine,
  hydromorphone, levophanol
• Severe chronic pain—Morphine sulfate
• Other adjunctive—antidepressants or
  anticonvulsants—depending on pain cause!
Joint Commission Standards
• Primary therapeutic outcomes:
• Relief of pain intensity and duration of pain complaint
• Prevention of the conversion of persistent pain to
  chronic pain
• Prevention of suffering and disability associated with
  pain
• Prevention of psychological & socioeconomic
  consequences associated with inadequate pain
  management
• Control of adverse effects
• Optimization of the ability to perform ADL’s
• Placebo therapy should never be used with pain
  management
Nursing Process: Pain Management
•   Pain is 5th Vital Sign
•   Assessed every time VS are taken & recorded
•   Pain flow sheets
•   Evaluate pain immediately before and after
    administration at 1, 2, and 3 hour intervals PO
•   At 15-30 min intervals after parenteral administration
•   Data Sheets:
•   Rating before and after
•   Nonpharmacologic measures initiated
•   Patient teaching performed
•   Breakthrough pain measures implemented
Nursing Process: PM
•   Believe patients report
•   Consider past history, subjective experiences, feelings
•   Consider psychological, physical and environmental factors—rest, low lighting,
    quiet, hydration, back rub, repositioning, hot or cold applications, relaxation
    techniques, diversion activities
•   Be consistent
•   Tools:
•   Riley for Infants—face, legs, activity, cry consolability FLACC Scale nonverbal client
•   Pain Observation Scale—young children 1-4 yrs. POCIS
•   Modified Objective Pain Score MOPS—children 1-4 yrs. after ENT surgery
•   Toddler-Preschooler Postop Pain Scale TPPPS—following medical or surgical
    procedures
•   Postop Pain Score POPS—infants surgical procedures
•   Neonatal Infant Pain Scale NIPS—preterm and full-term neonates painful
    procedures
•   Wong-Baker– 3 yrs. And older as well as adults with language barriers, who don’t
    read, select faces
Nursing Process: PM
• Scale 0-10
1—pulsing, throbbing
2—shooting, jumping
3—pricking, stabbing, boring
4—sharp, cutting, lacerating
5—pinching, gnawing, cramping, crushing
6—tugging, pulling, wrenching
7—hot, burning, scalding, searing
8—tingling, itchy, stinging
9—dull, sore, hurting, aching, heavy
10—tender, taut, rasping, splitting
Others
11—exhausting                             16—annoying, miserable, intense,
                                                    unbelievable
12—sickening, suffocating                 17—spreading, radiating, penetrating,
                                                    piercing
13—fearful, frightening, terrifying       18—tight, numb, squeezing, tearing
14—punishing, cruel, vicious, killing     19—cool, cold, freezing
15—wretched, blinding                     20—nagging, nauseating, agonizing,
dreadful,                                 torturing
Nursing Process: PM

•   How does your pain change with time?
•   1. Continuous
•       Steady
•       Constant
•   2. Rhythmic
•       Periodic
•       Intermittent
•   3. Brief
•      Momentary
•      Transient
•   What kinds of things relieve your pain?
•   What kinds of things increase your pain?
Nursing Process: PM
Lifespan Considerations:
Maintain steady blood level of analgesic—best control
ADME are affected by age
Dosages & frequency increased in children, especially
teenager (metabolism)
Older Adults smaller dosages (slow metabolism &
excretion)
Make regular assessments on pain level
Contact provider for adjustments in dose & frequency
based on responses
Before initiating pain assessment: assess hearing & visual
impairment
Nursing Process: PM Assessment
• Medication history
   – What meds
   – How effective
   – Adverse effects
• Patient’s perception—causes
• Believe pain experience
• Onset—when pain was 1st noticed, abrupt, occur with
  eating food
• Location--exactly where is your pain
• Depth—does sensation spreading out or diffusing, localized
• Quality—actual sensation felt like dull, sharp stabbing
• Duration—continuous or intermittent, how often
• Severity—rate your pain using pain methodology
Nursing Process: PM Assessment
• Nonverbal Observations—body position, facial
  grimace, immobility of particular part, holding
  extremity, think about developmental differences--
  clingy to parents, irritable baby, teens deny pain in
  front of peers
• Pain relief—specific measure, measure tried, beneficial
• Physical Data—always examine affected part for
  alterations in appearance, sensational changes,
  limitation or ROM
• Behavioral Responses—coping mechanisms, manages,
  crying, anger, withdrawal, depression, anxiety, fear,
  ADL’s
Nursing Diagnoses
•   Acute Pain
•   Chronic Pain
•   Urinary Retention
•   Impaired Gas Exchange
•   Risk for Constipation
Nursing Process: PM Planning
•   History of Pain Experience
     – Evaluate pain location, depth, quality, duration and severity
     – Perform baseline VS at least Qshift or more by condition and type of meds
•   Pain Relief
     – Goal of treatment established when initiating regimen, prevention, reduction or elimination,
       capacity, QOL, and ability to retain independence
          •   Pain at rest < 3
          •   Pain with movement < 5
          •   At least 6 hrs. of sleep uninterrupted by pain
          •   Able to work at hobby
•   Update care plan
•   Implement nonpharmacologic & pharmacology
•   During 1st 24 hours reassess often evaluate degree of pain relief provide reassurance
•   Environmental Control of quiet, little distraction of rest, modify schedules, schedule
    diversional activities
•   Psychological Interventions get staff involve in rest, understanding, providing
    diversional activities
•   Med Administration
     – Check degree of pain relief
     – Keep adequate supply
Nursing Process: PM Implementing
• Comfort Measures
    – Basic hygiene
    – Back rubs, massage, hot/cold application
    – Support affected part, give med in advance
• Exercise and Activity
    – Moderate if not contraindicated
• Non-pharmacologic Approaches
    –   Relaxation
    –   Visualization
    –   Meditation
    –   Biofeedback
    –   TENS
• Medication
    – Request pain meds
    – Encourage open communication
    – PCA
• Pain Control
    – Anticipate their need
• Nutritional Aspects
    – Eat well balanced diet high in B-complex, vitamins, limit or eliminate sugar,
      nicotine, caffeine, alcohol, 8 glass of water daily
Education and Health Promotion
• Orient client, family & significant others to benefits of adequate
  pain control
• Work with them to determine perception of pain management, use
  of drug & non-pharmacologic approaches
• Stress addiction is not a major factor with short-term use
• With long term use is to obtain sufficient pain control to ensure
  comfort
• Teach what meds are available
• Teach how and when to request them
• Discuss patient expectations
• Ask what level of exercise is attainable without severe pain
• Assess changes in expectations
• Constantly report duration and intensity to provider
• Assist with effective coping
• Teach self-administration
• Make sure family understand how to obtain assistance
Education and Health Promotion
• Fostering Health Maintenance
   – Discuss med information
   – How it will benefit
   – Combination of meds & comfort measures, relaxation, meditation, stress
     reduction, meeting total care needs to ensure ADL’s
   – Provide important information
   – Health teaching of adverse effects
   – Seek cooperation & understanding of:
        •   Adherence
        •   Name of Meds
        •   Dosage
        •   Route
        •   Times
        •   Common & Serious Adverse effect
• Written Record
   –   Frequency of attack
   –   Activity performed
   –   When
   –   Techniques used for control
   –   Degree of relief
Drug Class: Opiate Agonist
• Opiate Agonists—naturally occurring semisynthetic and synthetic drugs
    –   Relieve severe pain without loss of consciousness
    –   Stimulate opiate receptor in CNS
    –   Produce physical dependence
    –   Prolonged use produce tolerance or psychological & physical dependence
        (addiction)
• Uses: relieve acute or chronic moderate to severe pain…injury, postop,
  renal or biliary, MI or cancer
• Perform neurologic assessment: orientation, alertness, hand grip, motor
  function
• Take VS hold if RR < 12/min
• Check prior analgesics
• Check bowel sounds and consistency of stools
• Review voiding pattern & urine output
• CAE: lightheaded, dizziness, sedation, confusion, orthostatic hypotension,
  N/V, constipation
• SAE: respiratory depression, urinary retention, abuse
• Interactions CNS, Dilantin, Tegretol, SSRI—tramadol, warfarin
Class: Opiate Partial Agonist
•   Nubain, Talwin, Stadol…etc.
•   Depends of previous agonist administration
•   Potency 1st few weeks similar to Morphine
•   Prolonged use tolerance
•   Increasing dose doesn’t produce increase analgesia but increase adverse effects—
    ceiling effect
•   Will induce withdrawal in those addicted to agonist opioids
•   Uses: short term relief up to 3 wks of moderate to severe pain in cancer, burns,
    renal colic, preop, obstetric
•   Outcomes: relief of intensity & duration, conversion of persistent pain, prevention
    of suffering, control adverse effects, ADL’s
•   Perform baseline neurocheck: orientation, mental alertness, hand grip, motor
    functioning
•   Take VS
•   Check bowel sounds and prior opiate agonist use
•   Review voiding pattern & urine output
•   CAE: clamminess, sedation, sweating, dizziness, N/V/dry mouth, constipation
•   SAE: confustion, disorientation, hallucination, respiratory depression, Abuse
Class: Opiate Antagonists
• Naloxone pure because it has no effect on its own other
  than reverse CNS depressant
• Withdrawal in addicted clients of agonists
• Added to Talwin to reduce abuse by blocking euphoria
• Choice treatment for reversal of respiratory depression
• Neurocheck: orientation, LOC, hand grip, motor
  functioning
• VS: BP, HR, RR at frequent intervals
• Check prior dependence of agonists
• Have supportive equipment available
• Check bowel sign. Review voiding & urine output
• CAE: apathy, N/V, anorexia, mental depression
Drug Class: Salicylates
•   Most common used
•   Relief of slight to moderate pain
•   Analgesic, antipyretic, anti-inflammatory
•   Inhibit formation, production of S/S of inflammation, synthesis &
    release of prostaglandins
•   Combination effects as choice drug for above
•   Can be taken long term without dependence
•   Inhibition of platelet aggregation by blocking thromboxane A2
•   Enhances bleeding time
•   Reduce risk of recurrent TIAs or stroke, MI with previous episodes
•   Outcomes: reduced pain, inflammation, eliminate fever,
    antiplatelet
Drug Class: NSAIDs
Drug Class: Misc Analgesics
•   Acetaminophen—Tylenol
•   Synthetic non-opiate analgesic
•   Works by prostaglandin inhibition in CNS
•   Blocks generation of pain impulses in peripheral tissue
•   Antipyresis by inhibiting heat regulating center in hypothalamus
•   Used: discomfort associated with bacterial & viral infection,
    headache, musculoskeletal pain
•   Client who can’t take ASA products, anticoagulants, or possible
    bleeding problems from Gastric or Duodenal Gastritis & Hiatus
    Hernia
•   Not effective in RA
•   Outcome: Reduced pain & fever
•   CAE: gastric irritation
•   SAE: liver toxicity

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Pharmacology -pain management 3

  • 2. Pain Management • Analgesics relieve pain without producing loss of consciousness or reflex activity • Should be potent • Should not cause dependence • Should exhibit little adverse effects: constipation, hallucinations, respiratory depression, N/V • Should not cause tolerance • Should act promptly 7 over a long period w/little amount of sedation
  • 3. Pain Management • Classifications: • Opioid Agonist • Partial Opioid Agonist • Opioid Antagonists • Salicylates • NSAIDs • Misc. Analgesic Agents
  • 4. Pain Actions • Pathways to pain tranasmission from the site of injury to the brain for processing & reflexive action • First step: • Nociceptors – Transduction – Transmission – Perception – modulation
  • 5. Pain Action • Nociceptor – Stimulation of receptors at nerve endings (skin, blood vessel, joints, SQ, periosteum, viscera) – Classified—thermal, chemical, mechanical- thermal based on type of sensation they transmit
  • 6. Pain Actions • Important to Nociceptors is the transduction phase for meds to causing their effects • Transduction – 1. noxious stimuli causes cell damage with release of sensitizing chemicals • Prostaglandins • Bradykinin • Serotonin • Substance P • Histamine – 2. these substances activate nociception and lead to generation of action potential
  • 7. Pain Actions • Neurotransmitters role in tranmission of nerve impulses • Somatostatin • Cholecystokinin • Substance P
  • 8. Pain Actions • In the CNS there are 4 pain-transmitting pathways to various areas of the brain for response—opiate receptors – Mu—induce central analgesia, euphoria, dependence, miosis, resp. depression – Delta—limbic for euphoria – Kappa—responsible for analgesia, sedation, dysphoria – Epsilon- – Sigma (opioid & partial agonists)—autonomic stimulation, hallucinations, sysphoria
  • 9. Pain Actions • Blocking chemicals: • Histamine • Prostaglandins • Serotonin • Leukotrienes • Substance P • Bradykinin • Antihistamines—benadryl, • Prostglandins Inhibitors—NSAIDs • Substance P Antagonists—capsaicin • Antidepressants—prolong norepinephrine and serotonin- TCA, SSRI
  • 10. Pain Actions • Adjunct Agents • Adrenergic – Norepinephrine – Clonidine • GABA Receptor Stimulants—block nociceptor activity • Baclofen • Gabapentin • Valproic Acid--block trigeminal neuralgia • Phenytoin • Gabapentin • Caarbamazepine • TCA—inhibit reuptake of serotonin & norepinephrine causing rapid anagelsia • Bisphosphonate—pamidronate effective treating bony metastases
  • 11. Pain Stepwise Approach 1. Non-opioid +/- Adjuvant—pain persisting or increasing 2. Opioid for mild to moderate pain—pain persisting or increasing +/- Non-opioid +/-Adjuvant 3. Opioid for moderate to severe pain Non-opioid +/- Adjuvant
  • 12. Pain Recommendations • Mild acute pain—ASA, NSAIDs, or Tylenol • Inflammatory pain—NSAIDs • Unrelieved moderate pain—moderate potency— codeine or oxycodone often combination w/Tylenol or ASA • Severe acute pain—opioid agonist-Morphine, hydromorphone, levophanol • Severe chronic pain—Morphine sulfate • Other adjunctive—antidepressants or anticonvulsants—depending on pain cause!
  • 13. Joint Commission Standards • Primary therapeutic outcomes: • Relief of pain intensity and duration of pain complaint • Prevention of the conversion of persistent pain to chronic pain • Prevention of suffering and disability associated with pain • Prevention of psychological & socioeconomic consequences associated with inadequate pain management • Control of adverse effects • Optimization of the ability to perform ADL’s • Placebo therapy should never be used with pain management
  • 14. Nursing Process: Pain Management • Pain is 5th Vital Sign • Assessed every time VS are taken & recorded • Pain flow sheets • Evaluate pain immediately before and after administration at 1, 2, and 3 hour intervals PO • At 15-30 min intervals after parenteral administration • Data Sheets: • Rating before and after • Nonpharmacologic measures initiated • Patient teaching performed • Breakthrough pain measures implemented
  • 15. Nursing Process: PM • Believe patients report • Consider past history, subjective experiences, feelings • Consider psychological, physical and environmental factors—rest, low lighting, quiet, hydration, back rub, repositioning, hot or cold applications, relaxation techniques, diversion activities • Be consistent • Tools: • Riley for Infants—face, legs, activity, cry consolability FLACC Scale nonverbal client • Pain Observation Scale—young children 1-4 yrs. POCIS • Modified Objective Pain Score MOPS—children 1-4 yrs. after ENT surgery • Toddler-Preschooler Postop Pain Scale TPPPS—following medical or surgical procedures • Postop Pain Score POPS—infants surgical procedures • Neonatal Infant Pain Scale NIPS—preterm and full-term neonates painful procedures • Wong-Baker– 3 yrs. And older as well as adults with language barriers, who don’t read, select faces
  • 16. Nursing Process: PM • Scale 0-10 1—pulsing, throbbing 2—shooting, jumping 3—pricking, stabbing, boring 4—sharp, cutting, lacerating 5—pinching, gnawing, cramping, crushing 6—tugging, pulling, wrenching 7—hot, burning, scalding, searing 8—tingling, itchy, stinging 9—dull, sore, hurting, aching, heavy 10—tender, taut, rasping, splitting Others 11—exhausting 16—annoying, miserable, intense, unbelievable 12—sickening, suffocating 17—spreading, radiating, penetrating, piercing 13—fearful, frightening, terrifying 18—tight, numb, squeezing, tearing 14—punishing, cruel, vicious, killing 19—cool, cold, freezing 15—wretched, blinding 20—nagging, nauseating, agonizing, dreadful, torturing
  • 17. Nursing Process: PM • How does your pain change with time? • 1. Continuous • Steady • Constant • 2. Rhythmic • Periodic • Intermittent • 3. Brief • Momentary • Transient • What kinds of things relieve your pain? • What kinds of things increase your pain?
  • 18. Nursing Process: PM Lifespan Considerations: Maintain steady blood level of analgesic—best control ADME are affected by age Dosages & frequency increased in children, especially teenager (metabolism) Older Adults smaller dosages (slow metabolism & excretion) Make regular assessments on pain level Contact provider for adjustments in dose & frequency based on responses Before initiating pain assessment: assess hearing & visual impairment
  • 19. Nursing Process: PM Assessment • Medication history – What meds – How effective – Adverse effects • Patient’s perception—causes • Believe pain experience • Onset—when pain was 1st noticed, abrupt, occur with eating food • Location--exactly where is your pain • Depth—does sensation spreading out or diffusing, localized • Quality—actual sensation felt like dull, sharp stabbing • Duration—continuous or intermittent, how often • Severity—rate your pain using pain methodology
  • 20. Nursing Process: PM Assessment • Nonverbal Observations—body position, facial grimace, immobility of particular part, holding extremity, think about developmental differences-- clingy to parents, irritable baby, teens deny pain in front of peers • Pain relief—specific measure, measure tried, beneficial • Physical Data—always examine affected part for alterations in appearance, sensational changes, limitation or ROM • Behavioral Responses—coping mechanisms, manages, crying, anger, withdrawal, depression, anxiety, fear, ADL’s
  • 21. Nursing Diagnoses • Acute Pain • Chronic Pain • Urinary Retention • Impaired Gas Exchange • Risk for Constipation
  • 22. Nursing Process: PM Planning • History of Pain Experience – Evaluate pain location, depth, quality, duration and severity – Perform baseline VS at least Qshift or more by condition and type of meds • Pain Relief – Goal of treatment established when initiating regimen, prevention, reduction or elimination, capacity, QOL, and ability to retain independence • Pain at rest < 3 • Pain with movement < 5 • At least 6 hrs. of sleep uninterrupted by pain • Able to work at hobby • Update care plan • Implement nonpharmacologic & pharmacology • During 1st 24 hours reassess often evaluate degree of pain relief provide reassurance • Environmental Control of quiet, little distraction of rest, modify schedules, schedule diversional activities • Psychological Interventions get staff involve in rest, understanding, providing diversional activities • Med Administration – Check degree of pain relief – Keep adequate supply
  • 23. Nursing Process: PM Implementing • Comfort Measures – Basic hygiene – Back rubs, massage, hot/cold application – Support affected part, give med in advance • Exercise and Activity – Moderate if not contraindicated • Non-pharmacologic Approaches – Relaxation – Visualization – Meditation – Biofeedback – TENS • Medication – Request pain meds – Encourage open communication – PCA • Pain Control – Anticipate their need • Nutritional Aspects – Eat well balanced diet high in B-complex, vitamins, limit or eliminate sugar, nicotine, caffeine, alcohol, 8 glass of water daily
  • 24. Education and Health Promotion • Orient client, family & significant others to benefits of adequate pain control • Work with them to determine perception of pain management, use of drug & non-pharmacologic approaches • Stress addiction is not a major factor with short-term use • With long term use is to obtain sufficient pain control to ensure comfort • Teach what meds are available • Teach how and when to request them • Discuss patient expectations • Ask what level of exercise is attainable without severe pain • Assess changes in expectations • Constantly report duration and intensity to provider • Assist with effective coping • Teach self-administration • Make sure family understand how to obtain assistance
  • 25. Education and Health Promotion • Fostering Health Maintenance – Discuss med information – How it will benefit – Combination of meds & comfort measures, relaxation, meditation, stress reduction, meeting total care needs to ensure ADL’s – Provide important information – Health teaching of adverse effects – Seek cooperation & understanding of: • Adherence • Name of Meds • Dosage • Route • Times • Common & Serious Adverse effect • Written Record – Frequency of attack – Activity performed – When – Techniques used for control – Degree of relief
  • 26. Drug Class: Opiate Agonist • Opiate Agonists—naturally occurring semisynthetic and synthetic drugs – Relieve severe pain without loss of consciousness – Stimulate opiate receptor in CNS – Produce physical dependence – Prolonged use produce tolerance or psychological & physical dependence (addiction) • Uses: relieve acute or chronic moderate to severe pain…injury, postop, renal or biliary, MI or cancer • Perform neurologic assessment: orientation, alertness, hand grip, motor function • Take VS hold if RR < 12/min • Check prior analgesics • Check bowel sounds and consistency of stools • Review voiding pattern & urine output • CAE: lightheaded, dizziness, sedation, confusion, orthostatic hypotension, N/V, constipation • SAE: respiratory depression, urinary retention, abuse • Interactions CNS, Dilantin, Tegretol, SSRI—tramadol, warfarin
  • 27. Class: Opiate Partial Agonist • Nubain, Talwin, Stadol…etc. • Depends of previous agonist administration • Potency 1st few weeks similar to Morphine • Prolonged use tolerance • Increasing dose doesn’t produce increase analgesia but increase adverse effects— ceiling effect • Will induce withdrawal in those addicted to agonist opioids • Uses: short term relief up to 3 wks of moderate to severe pain in cancer, burns, renal colic, preop, obstetric • Outcomes: relief of intensity & duration, conversion of persistent pain, prevention of suffering, control adverse effects, ADL’s • Perform baseline neurocheck: orientation, mental alertness, hand grip, motor functioning • Take VS • Check bowel sounds and prior opiate agonist use • Review voiding pattern & urine output • CAE: clamminess, sedation, sweating, dizziness, N/V/dry mouth, constipation • SAE: confustion, disorientation, hallucination, respiratory depression, Abuse
  • 28. Class: Opiate Antagonists • Naloxone pure because it has no effect on its own other than reverse CNS depressant • Withdrawal in addicted clients of agonists • Added to Talwin to reduce abuse by blocking euphoria • Choice treatment for reversal of respiratory depression • Neurocheck: orientation, LOC, hand grip, motor functioning • VS: BP, HR, RR at frequent intervals • Check prior dependence of agonists • Have supportive equipment available • Check bowel sign. Review voiding & urine output • CAE: apathy, N/V, anorexia, mental depression
  • 29. Drug Class: Salicylates • Most common used • Relief of slight to moderate pain • Analgesic, antipyretic, anti-inflammatory • Inhibit formation, production of S/S of inflammation, synthesis & release of prostaglandins • Combination effects as choice drug for above • Can be taken long term without dependence • Inhibition of platelet aggregation by blocking thromboxane A2 • Enhances bleeding time • Reduce risk of recurrent TIAs or stroke, MI with previous episodes • Outcomes: reduced pain, inflammation, eliminate fever, antiplatelet
  • 31. Drug Class: Misc Analgesics • Acetaminophen—Tylenol • Synthetic non-opiate analgesic • Works by prostaglandin inhibition in CNS • Blocks generation of pain impulses in peripheral tissue • Antipyresis by inhibiting heat regulating center in hypothalamus • Used: discomfort associated with bacterial & viral infection, headache, musculoskeletal pain • Client who can’t take ASA products, anticoagulants, or possible bleeding problems from Gastric or Duodenal Gastritis & Hiatus Hernia • Not effective in RA • Outcome: Reduced pain & fever • CAE: gastric irritation • SAE: liver toxicity