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Clinical Trials –
Randomised Treatment
Allocation using Excel
SC Chopra
sccpharma@gmail.com
Plus points of Excel method
Easy to use
Predictably
unpredictable
Immune to
manipulations
Problems of Excel Method
Technical
Proficiency
required
Removes
Blinding of User
Utility of Presented Method
Pharmacist
Director of
Program
Clinical
Investigator
Highlights of Presented Method
• Advance allocation for required “n”
• Uncovered as the Patient ID is filled in
• Can be m...
Let Us Start
Open Sheet 2 of
a new workbook
Prepare sheet as
in next slide
Maximum No. of Treatments
• Enter 1 in A4
• Enter formula in A5
• Copy formula in A6:A13
• Shows Sr. No. upto no. of
treat...
`
• Enter formula in B4
• Copy formula In B5:B13
• Gives alphabetic characters
as treatment code
Description of required
treatments in Column C
• Enter formula in D4
• Copy formula in D5:D13
• Shows no. of patients
allocated to each treatment
(Results will appear af...
Sum of D4:D13 (Total no.
of patients allocated to all
treatments.
Should be = Total no. of
patients
What Have We Done So Far
Sr. No. of Treatments
Treatment Codes
Treatment Description
No. of patients allocated to each
tre...
Next Step
Entering no.
of patients
Random
allocation
Sr No of Patients (SN_P)
from 1 to desired no. by
your preferred method
• Randomised treatment
(Formula in Formula Box)
• Copy formula to all
patients by your preferred
method
Link the two tables on Sheet 1
On sheet 1, put in the compiled information
• SN_P in Column A of sheet1
• You may copy from SN_P of Sheet B
• Leave Patient ID blank at present
• Enter this formula in C4 (Gives treatment
code for patiemt)
• No result will be visi...
• Enter this formula in D4 (Gives Description
of Treatment Code)
• No result will be visible in D4
• Copy formula down for...
• If distribution of patients allocated to each treatment (Col. D of Sheet 2)
is NOT acceptable, press F9 to change the al...
Acceptable
Allocation?`
• After obtaining an acceptable allocation, make it permanent by
selecting Treatment No. Column (Col J), copying it and th...
Blank look except for SN_P
• Enter Patient ID for 1st patient.
• Treatment Code and Description
appear automatically
• Other columns can be used for
...
4 stands
for D
4 stands
for D
4 stands
for D
In case of difficulty, please email me.
Mail ID is given on title slide
Random treatment allocation in clinical trials
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Helps in allocating patients to different treatment groups in Clinical Trials, using MS Excel

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Random treatment allocation in clinical trials

  1. 1. Clinical Trials – Randomised Treatment Allocation using Excel SC Chopra sccpharma@gmail.com
  2. 2. Plus points of Excel method Easy to use Predictably unpredictable Immune to manipulations
  3. 3. Problems of Excel Method Technical Proficiency required Removes Blinding of User
  4. 4. Utility of Presented Method Pharmacist Director of Program Clinical Investigator
  5. 5. Highlights of Presented Method • Advance allocation for required “n” • Uncovered as the Patient ID is filled in • Can be modified by any Excel-literate person
  6. 6. Let Us Start Open Sheet 2 of a new workbook Prepare sheet as in next slide
  7. 7. Maximum No. of Treatments • Enter 1 in A4 • Enter formula in A5 • Copy formula in A6:A13 • Shows Sr. No. upto no. of treatments & then “”
  8. 8. ` • Enter formula in B4 • Copy formula In B5:B13 • Gives alphabetic characters as treatment code
  9. 9. Description of required treatments in Column C
  10. 10. • Enter formula in D4 • Copy formula in D5:D13 • Shows no. of patients allocated to each treatment (Results will appear after next step)
  11. 11. Sum of D4:D13 (Total no. of patients allocated to all treatments. Should be = Total no. of patients
  12. 12. What Have We Done So Far Sr. No. of Treatments Treatment Codes Treatment Description No. of patients allocated to each treatment Total No. of Patients
  13. 13. Next Step Entering no. of patients Random allocation
  14. 14. Sr No of Patients (SN_P) from 1 to desired no. by your preferred method
  15. 15. • Randomised treatment (Formula in Formula Box) • Copy formula to all patients by your preferred method
  16. 16. Link the two tables on Sheet 1 On sheet 1, put in the compiled information
  17. 17. • SN_P in Column A of sheet1 • You may copy from SN_P of Sheet B
  18. 18. • Leave Patient ID blank at present • Enter this formula in C4 (Gives treatment code for patiemt) • No result will be visible in C4 at present (Will appear only when Patient ID is filled) • Copy formula down for other patients too
  19. 19. • Enter this formula in D4 (Gives Description of Treatment Code) • No result will be visible in D4 • Copy formula down for other patients too
  20. 20. • If distribution of patients allocated to each treatment (Col. D of Sheet 2) is NOT acceptable, press F9 to change the allocation. If this too is NOT acceptable, go on pressing F9 till you get an acceptable distribution. • Please remember that it is very rare for each group to be allocated the same number of patients
  21. 21. Acceptable Allocation?`
  22. 22. • After obtaining an acceptable allocation, make it permanent by selecting Treatment No. Column (Col J), copying it and then using the Paste Special => Values functions • Switch to Sheet 1.
  23. 23. Blank look except for SN_P
  24. 24. • Enter Patient ID for 1st patient. • Treatment Code and Description appear automatically • Other columns can be used for relevant patient data From where did this Treatment Code come?
  25. 25. 4 stands for D 4 stands for D 4 stands for D
  26. 26. In case of difficulty, please email me. Mail ID is given on title slide

Helps in allocating patients to different treatment groups in Clinical Trials, using MS Excel

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