Cell within a tumor that possess the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor”. “CSC can thus only be defined experimentally by their ability to recapitulate the generation of a continuously growing tumor”.

1. By
SATHISHKUMAR G
(sathishsak111@gmail.com)

2. TUMOR HETEROGENEITY
ANGIOSARCOMA

3. PROMOTIO
N
INITIATI
ON
PROGRESS
ION
NORMAL
CELL
BENIGN
TUMOR
MUTATED
CELL
MALIGNANT
TUMOR
FIRST
MUTATION
PROLIFERATI
ON
MALIGNANT
PHENOTYPE
ACQUISITION

5.  1874 – Durante - hypothesis of cancer origin
from a rare population of normal cells with stem
cell properties
 1875 – Cohnheim - embryonal rest theory

6.  1956 – Makino - Further evidence favoring the concept of the
stem cell in ascites tumors of rats.
 1963 - Bruce & Van Der Gaag - A quantitative assay for the
number of murine lymphoma cells capable of proliferation
in vivo.
 1967 – Pierce - Teratocarcinoma: model for a
developmental concept of cancer.
 1977 - Hamburger and Salmon - hypothesis that some
cancers contain a small subpopulation of cells that are similar
to normal stem cells

7.  “Cell within a tumor that possess the capacity to
self-renew and to cause the heterogeneous
lineages of cancer cells that comprise the tumor”.
 “CSC can thus only be defined experimentally by
their ability to recapitulate the generation of a
continuously growing tumor”.

8. 

9.  Somatic stem cells
 Adult progenitor cells
 Adult somatic cells

10.  Self-renewal
 Diverse progeny
 Immortality
asymmetric mitosis

12. TELOMERASEACTIVITY

13.  Metastases formation
 Chemotherapy resistance
 Radiotherapy resistance
 Reccurence

14. 
PRIMARY
TUMOR
METASTASIS

16.  THERAPY
 DIAGNOSTICS

18.  Brain tumours - the ability of tumour cells to
propagate neurospheres in culture and high
CD133 expression associated with a reduced
time of disease-free survival and overall survival

19.  Some tumors consists mainly of tumorigenic cells
 CSC model tested on only a small subset of cancers
 Currently used methods underestimate the frequency of
human cancer cells with tumorigenic potential
 Tumors contain neoplastic as well as non-neoplastic stromal
and immune cells
 Debris from dying cells and necrotic tissue can appear
indistinguishable from live cells by flow cytometry

20.  Stem cells show great promise for regenerative
medicine.
 Ethical concerns need to be taken into account.
 Proper guidelines are needed to ensure
appropriate conduct of the research.