Israel is a global leader in innovative neurological therapies and research. It hosts numerous companies developing advanced technologies like deep brain stimulation devices, MRI-guided focused ultrasound for brain disorders, and transcranial magnetic stimulation systems that have shown efficacy in treating Alzheimer's, depression, and other conditions. Israel also supports large clinical trials and prizes for breakthroughs in neurotechnology due to factors like government funding and a culture valuing scientific innovation.
1. “Deeper understanding of how the brain operates
will enable us to better understand ourselves.”
His Excellency Shimon Peres, President of the
State of Israel
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2. Israel Brain Technologies and the $1M
B.R.A.I.N. Prize
September 12, 2012:$1 Million Global B.R.A.I.N. Prize
Announced by Israel Brain Technologies. $1M Prize for
Breakthroughs in Neurotechnology
Inspired by Israeli President Shimon Peres, Prize Will
Recognize a Breakthrough Achievement in Brain
Technology That Will Change Lives.
Winner to be announced at BrainTech Israel 2013
Conference 14-15 October.
http://www.youtube.com/watch?v=QZ0rTxWTvIA&fe
ature=youtu.be
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3. Obama Brain Mapping Initiative
April 2, 2013. President Obama on Tuesday announced
a broad new research initiative, starting with $100
million in 2014, to invent and refine new technologies
to understand the human brain
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4. What are neurological conditions?
Neurological diseases and disorders are those which
affect the brain, spinal cord and nerves throughout the
body. They refer to a malfunction in a portion or
several areas of the nervous system, which cause a
number of difficulties to occur immediately or
progressively over time. Some of these challenges
include problems with mobility, mental tasks (such as
learning and memory), basic functions (such as
swallowing and breathing), or emotional changes in
mood. In the worst cases, a neurological deficit can
lead to a shortened life expectancy.
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5. The USA Business Conference Board
give us a human reason for interest
Cognitive neuroscience, by showing us how we look at
the world, can teach us new ways to improve
performance.
Knowing how the brain works — how people think
and why they act and react as they do — can be an
advantage in the workplace, where leading change and
convincing people to follow are cornerstones of
effective leadership.
Decision making, it turns out, is not all logical; it is
emotional, too.
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6. Huge and unsustainable costs as a
reason for concern, research & action.
The cost of caring for Americans with Alzheimer's and
other forms of dementia may now be as high as $215
billion a year -- more than the cost of caring for heart
disease or cancer, a new study finds.
And that number is expected to escalate as the elderly
population grows.
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7. There are, correct, emotional, human
reasons for brain disease focus
Americans fear developing Alzheimer’s disease more
than cancer, stroke, heart disease and any other life-
threatening illness, according to a Marist Institute poll
released this week on behalf of Home-Instead Senior
Care.
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8. There is a visual ecomap of the large
extent of Israeli brain research
http://www.israelbrain.org/wp-
content/uploads/2012/08/DA_Israel_brain_Eco_w_lin
ks.pdf
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9. BioNess
BioNess is the world leader developing and marketing
Neuro-Stimulation devices for the leg and arm to give
victims of stroke and other neuro-conditions, such as
MS and CP, effective motion. The devices know the
relevant nerves and how to stimulate them to enable
patients to walk and grasp, for example.
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10. BioNess enables young woman with MS
to resume full life
http://www.bioness.com/L300_for_Foot_Drop/In_
the_News.php
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11. Alpha Omega Engineering
Alpha Omega is a leader in developing and marketing
sophisticated and pioneering systems and micro-
electrodes that enable online neural stimulation and
recording for Neurosurgery & Neuroscience
Customer base: About 500 hospitals and research labs
throughout the world
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12. Alpha Omega systems for neuro-
surgery
The MicroGuide Pro™ by Alpha Omega is the world’s most advanced
intra-operative MER (Micro Electrode Recording) system for functional
neurosurgery - a comprehensive guidance unit available for target
localization in the surgical treatment of movement disorders.
NeuroNav Si™ is a state-of-the-art MER system used clinically in the
localization of surgical targets for the implantation of Deep Brain
Stimulators (DBS) or ablation of target structures, in the treatment of
neurological and psychiatric diseases. The NeuroNav Si ™ allows for the
safe an accurate introduction of electrodes into the brain, while
recording neural activity, stimulating neural tissue, and guiding the
user to the optimal target.
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13. Insightec
InSightec® is the pioneer and global leader in MRI guided focused
ultrasound technology for image guided acoustic surgery.
InSightec’s ExAblate® Neuro integrates high intensity Focused
Ultrasound Surgery with continuous Magnetic Resonance imaging
(MRI) to provide a non invasive, acoustic surgery platform for treating
neurological disorders without ionizing radiation through an intact
skull.
ExAblate® is the first system to use the MRI guided focused ultrasound
technology. In November 2012, ExAblate received the CE Mark for the
treatment of three neurological disorders, Essential Tremors,
Parkinson's and Neuropathic Pain.
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14. TMS—TransCranial Magnetic Stimulation
The next two companies use TMS technology
Transcranial magnetic stimulation (TMS) is a noninvasive
technique used to apply brief magnetic pulses to the brain.
The pulses are administered by passing high currents
through an electromagnetic coil placed adjacent to a
patient's scalp. The pulses induce an electric field in the
underlying brain tissue. When the induced field is above a
certain threshold, and is directed in an appropriate
orientation relative the brain's neuronal pathways,
localized axonal depolarizations are produced, thus
activating the neurons in the relevant brain structure.
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15. Neuronix
Neuronix is the only company in the world that has developed a system
that is clinically proven to increase cognitive levels in early and mid-stage
Alzheimer’s patients every day, and, based on the CE mark, is selling
systems and treating patients every day.
Neuronix systems utilize surface TMS in six cognitive areas of the brain,
the left and right parietals, the left and right frontal lobes and Broca’s area
(integrates speech) and Wernicke’s area (integrates hearing) with an
innovation that combines the TMS with a relevant “cognitive event”.
For example, when TMS is applied to Broca’s area for 20 seconds, the
patient reads for 20 seconds, and repeat; TMS is applied to Wernicke’s area
for 20 seconds and a recording is played for 20 seconds.
In a small but compelling trial at Harvard-Beth Israel, the Alzheimer's
patients increased their cognitive ability by about 1/3, from 20 on the
standard ADAS-COGS scale, they realized an improvement by 5.83 points.
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Neuronix Treatment Procedure
How is it actually performed?
1. Pre-Treatment:
a) Perform an MRI scan on patient’s brain
b) Locate and mark brain regions of
interest
Broca
Wernicke
Dorsolateral
Prefrontal
cortex
Somatosensor
y Association
Cortex
3.Cognitive Training:
a) “Tailor made” exercises, set to fit with
patient’s specific abilities
2. Focused Magnetic Stimulation:
a) Position coil to stimulate specific region
Concurrent
TMS coil
Patient
Cognitive
Training
screen
• Treatment phase
– 30 sessions:
5 days a week, 6 weeks, 45-60 mins
– Each session: 3 regions per day
17. BRAINSWAY
Brainsway has patented deep TMS, penetrating 4-5 mm into the brain
compared to the 1.5-3mm penetration of standard TMS. Deep TMS is
the non-invasive analog to the very invasive deep brain electrode
implant.
Brainsway has CE approval for the following indications
Major Depressive Disorder (FDA indication)
Bipolar Depression
Post-Traumatic Stress Disorder
Schizophrenia (negative symptoms)
Parkinson's Disease
Chronic Pain
Brainsway has FDA approval for depression.
Brainsway has been doing clinical trials for indications such as PSTD,
bi-polar disorder, autism, Tourette’s, MS, MCI & Alzheimer’s and
ADHD.
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18. Mazor Robotics
Mazor Robotics’ Renaissance™ , FDA approved, is transforming spine
surgery from freehand procedures to highly-accurate, state-of-the-art
robotic procedures, with less radiation—even for minimally invasive
surgery (MIS), scoliosis, and other complex spinal deformity cases.
Powered by Clinically Validated Technology -- Highly Accurate and Safe
Based on surgeons’ experience with thousands of SpineAssist® surgeries worldwide
tens of thousands of implants placed
No cases of permanent nerve damage
1.5 mm accuracy
Wide Range of Clinical Applications
Hardware and software tools enable a variety of spine procedures
Open, MIS, and percutaneous posterior thoracolumbar approaches
Scoliosis and other complex spinal deformities
Pedicle screws – short and long fusions
Transfacet screws and translaminar-facet screws
Osteotomies
Biopsies
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19. CNS Companies in Clinical Trials
Brainstorm is using mesenchymal stem cells converted to secrete
neurotrophic factors successfully to slow down always fatal ALS, Lou
Gehrig’s disease.
Neurim has successful phase 2 clinical trials for its Circadin to show
attenuation of cognitive deficits is early stage Alzheimer’s patients and
Piromelatine to be an effective non-hypnotic and non-narcotic soporific.
Brainsgate is developing a medical device to increase blood flow to the
brain to treat ischemic stroke and vascular issuficiencies.
ElMindA’s Brain Network Activation Pattern technology is in trials to give an
objective measurement of concussion and other neuro-indications by
sophisticated processing of high-channel EEG information.
Nervomatrix is using automatic probes to diagnose and treat lower back
pain.
Novocure is doing a Phase 3 clinical trial for glioblastoma in the brain using
an external, non-invasive AC generator to disrupt the tumor cells.
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20. Summary
Neuro-cognitive and degenerative (CNS) diseases, with
Alzheimer’s leading, are among the most intractable and costly
and distressing diseases. Without effective therapies with
minimal side effects, these diseases will break the healthcare
systems, patients and caregivers.
Current therapies are inadequate and so many standard
pharmaceutical responses have failed in late stage trials.
Only the most innovative solutions will yield effective therapies.
Israel, with its history & culture of scientific innovative
innovation, government support & early recognition of the
challenges of CNS, is poised to be a leader in effective CNS
therapies.
How can we make Israel’s leadership known to the world?
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21. For copy please email: howard.david.sterling@gmail.com
http://www.slideshare.net/sabahow/ilsi-conference-biomed-
presentation-brain-game-change-israel-leadership-in-cns-hds-
6-1013
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Notas do Editor
President Peres was not just talking the talk but presciently offered a $1 million prize for practical, human therapeutic breakthroughs.
So about a year later President Obama picks up on the idea Bout a year later, albeit at a 100x size.
Here is a quick definition of the diseases we care covering. Why are they important.
Now we will go onto individual Israeli companies involved in neurological disease. For want to a better system, the ones with systems in the market will be listed first. I am going to go pretty quickly to give a view of the number of companies and their importance. If you miss anything, please email me at howard.david.sterling@gmail.com , tell me you connection and reason for interest and I will email you a copy of the presentation.
Those of you who know Hebrew know Ness means Miracle and that well describes BioNess. BioNess is a hybrid company insofar as the devices were developed and are manufactured here in Israel and the headquarters of the company are in California.
With BioNess, a picture is worth more than any words I can say. So listen for one minute.
I would bet you did not know that here in Nazareth Illit is a leader in the most sophisticated equipment that enable neurosurgeons, the proverbial brain surgeons, to operate safely and successfully in the most difficult brain conditions such as epilepsy and brain tumors.
These types of devices are as sophisticated as it get, patients life and cognitive ability depend on the Alpha Omega devices.
So Broca’s area in the brain is considered to be where speech is integrated, you put your thoughts together your lips and tongue to make words so Neuronix gives 20 seconds of TMS to Broca’s area and the patient reads something for 20 seconds, and repeat. It is based on an old principle that neurons that fire together wire together.