A comprehensive presentation on Selenium metabolism and its clinical significance for MBBS ,BDS ,B.Tech ,B.Pharma and biotechnology students for self-study.

1. Selenium metabolism and its clinical significance
Dr. RohiniC Sane

3. Brazil nuts
DIETARY SOURCES OF SELENIUM

4. Selenium metabolism
• Stimulant of Growth
• Requirement : 50-100 microgram /day
• Normal serum Selenium level:
63-160 micrograms/L (adults )and 16-71( <2yrs of age )
Selenium dependent enzymes Site of enzyme
Glutathione peroxidase Human (RBC)
Formate dehydrogenase E. Coli
Glycine reductase Clostridium

5. RDA for Selenium

6. Functions of Selenium
1.Synthesis of T₃ from T₄ : T ₄ T₃ Deiodinase + Selenium ( selenium
deficiency -Hypothyroidism)
2. Prevent liver cirrhosis ,muscular dystrophy
3. Selenium essential for development of spermatozoa ( middle piece )
4. Seleno –Cysteine required for termination of protein biosynthesis
5. Anti oxidant ( vitamin E decreases seleniu requirement )à prevents lipid peroxidationà maintains cell
membrane integrity )
6. Selenium Prevents carcinogenesis ( binds Mercury, cadmium prevents toxic effect )
7.prevents Keshan’s disease à multifocal myocardial infarction , cardiac enlargement

7. Selenium functions as an Antioxidant

8. Selenium functions as an Antioxidant

9. Selenium Metabolism

10. Site of absorption of Selenium in human body

11. Selenosis :Selenium Toxicity
qSelenosis :dietary intake > 900 micrograms/day
• Causes : metal polishes & anti rust compounds
• Symptoms : hair loss ,falling of nails ,weight loss ,diarrhea ,Garlic odor
methylation ( Adenosyl Methionine )
H+Se Hydrogen Se Dimethyl Selenide
vManagement of Selenosis with Halogenated Hydroselenium

12. Effects of Selenosis in human body

13. Functions of Selenocysteine

14. Keshan Disease associated with Selenium deficiency

15. Keshan Disease associated with Selenium deficiency