A comprehensive presentation on Magnesium Metabolism and its clinical significance forMBBS,BDS,B.Tech ,B.Pharma students for self -study.

1. Metabolism of Magnesium
and its clinical applications
Dr. RohiniC Sane

3. Magnesium Metabolism
vMagnesium
a) Intracellular cation
b) 20 g /human body
c) 75% complexes with calcium
Daily dietary Requirement :
Men : à 400 mg/day
Women à 300 mg/day
Daily oral intake > 600 mg leads to diarrhea
Intravenous intake > 600 mg CNS depression

4. Magnesium Metabolism
vMagnesium dietary sources : cereals , beans ,leaf vegetables ,fish
vAbsorption of dietary Magnesium : proximal renal tubules
vNormal serum Magnesium concentration :1.8-2.2 mg /dl
Ionized Magnesium -60%
protein bound Magnesium -30%
Magnesium Bound to other ions -10%
vMagnesium in RBC - 5 meu/lt
vMagnesium in muscles - 20 meu/lt
vHomeostasis is maintained by kidney.
vAbsorption : through carrier protein ,PTH increases absorption of Mg²⁺

6. Magnesium Metabolism

7. Functions of Magnesium
vFunctions of Magnesium:
1. functions as activator of enzymes à Alkaline Phosphatase ,Hexokinase,
Fructokinase , Phosphofructokinase , Adenylate cyclase
C- Amp dependent kinase
2. Decreases Neuromuscular irritability
3. plays role in insulin sensitivity
4. Magnesium supplementation increases Glucose Tolerance
5. Magnesium deficiency decreases insulin dependent uptake of Glucose

8. Functions of Magnesium Metabolism

9. Magnesium deficiency
vHypomagnesaemia : serum concentration of Magnesium < 1.7 mg/dl
vCauses :
a) Diabetes Mellitus
b) Chronic alcoholism
c) Liver cirrhosis
d) Protein caloric malnutrition
e) Diuretic therapy
f) Hypocalcaemia/Hypokalemia
vDeficiency manifestation
1. Neuromuscular irritability
2. Tremors

10. Magnesium deficiency
vDeficiency manifestation
1. Neuromuscular irritability
2. Tremors similar to Hypocalcaemia
3. Carpo pedal spasm
4. Cardiac arrhythmia
Hyper Magnecemia : kidney failure

11. Neurological Manifestations in Magnesium deficiency

12. Common symptoms of Magnesium deficiency

13. Hypomagnesemia

14. Magnesium Metabolism in Hypomagnesemia

15. Magnesium Metabolism in Hypomagnesemia

16. Magnesium Metabolism