Innovatival Functionalized Nanomaterials for Biomedicalm Sensing and Composites Applications
1. 9/16/15
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Electrochemical
pH
Ionic Strength
Biological
Mechanical Electrical
Magnetic
Light
Temperature
What is “SMART”?
External
S+muli
Internal
S+muli
2. 9/16/15
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Increase stability and
promote an ordered
architecture
Decrease
extensive surface
functionalization
for eventual
degradation
Hard
Soft
Inorganic
Organic
Hybrid Materials
Hybrid Materials
3. Yang, X.; Moosa, B.; Deng, L.; Zhoa, L; Khashab, N. M. *
“Polymer Chemistry 2011, 2, 2543–2547.
Biomedical: pH-Triggered Micellar Membrane for
Controlled Release Microchips
!
0 5 10 15 20
0
10
20
30
40
50
b
time (h)
DOXrelease(wt%)
pH=4.0
pH=5.0
pH=6.0
pH=7.0
pH=8.0
pH=9.0
!
General Scheme
Assembly and Application
4. Deng, Lin; Wang, Guangchao; Ren, Jian; Zhang, Bei; Yan, Jingjing; Li, Wengang; Khashab, N. M. * RSC adv. 2012, 2,
12909–12914
Biomedical: Enzymatically Triggered System
Based on Hyaluronic Acid Micelles
General Scheme
5. Deng, Lin; Wang, Guangchao; Ren, Jian; Zhang, Bei; Yan, Jingjing; Li, Wengang; Khashab, N. M. * RSC adv. 2012, 2,
12909–12914.
Biomedical: Enzymatically Triggered System
Based on Hyaluronic Acid Micelles
6. Biomedical: Magnetically Triggered Theranostic Platform
for Remote Cancer Cells Therapy and Imaging
!
General Scheme
Zhang, W.; Deng, L.; Wang, G.; Guo, X.; Li, Q.; Zhang, J.; Khashab, N. M. * Part. Pat. Syst. Charact. 2014, 31, 985–993.
7. Biomedical: Magnetically Triggered Theranostic Platform
for Remote Cancer Cells Therapy and Imaging
!
Zhang, W.; Deng, L.; Wang, G.; Guo, X.; Li, Q.; Zhang, J.; Khashab, N. M. * Part. Pat. Syst. Charact. 2014, 31, 985–993.
8. Biomedical: Photo-Triggered Membrane Based on Inter-
particle Crosslinking for Decreasing Diffusion Rates
PHCA microspheres
EC membrane
IrradiationDrug Reservoir Drug Reservoir
Lower Efflux
Crosslinking
(A)
Membrane
PMMA device
Reservoir for
drug loading
(B)
(C1) (C3)(C2)
b
c
a
d
(A)
(B)
Song, L., Moosa, M., Li, W.; Khashab, N. M.* J. Mater. Chem. B 2015, 3, 1208–1216.
9. Deng, L.; Li, Q.; Yang, Y.;Omar, H; Tang, N.; Zhang,J.; Nie, Z.; Khashab, N. M.* Chem. Eur. J. 2015, accepted (chem.201502522)
.
Biomedical: Graphene Oxide-Wrapped Gold
Nanorods
General Scheme
!
“Two-Step” Raman Imaging-Guided Chemo-Photothermal Cancer Therapy
10. Deng, L.; Li, Q.; Yang, Y.;Omar, H; Tang, N.; Zhang,J.; Nie, Z.; Khashab, N. M.* Chem. Eur. J. 2015, accepted (chem.201502522)
Biomedical: Graphene Oxide-Wrapped Gold
Nanorods
!
11. Deng, L.; Li, Q.; Yang, Y.;Omar, H; Tang, N.; Zhang,J.; Nie, Z.; Khashab, N. M.* Chem. Eur. J. 2015, accepted (chem.201502522)
.
Biomedical: Graphene Oxide-Wrapped Gold
Nanorods
SERS mapping of Doxorubicin (a) and
Graphene oxide (b) on AuNRs, ratio of
Doxorubicin to graphene oxide (c), and
overlap image (d) in Hela cell
12. Deng, L.; Li, Q.; Yang, Y.;Omar, H; Tang, N.; Zhang,J.; Nie, Z.; Khashab, N. M.* Chem. Eur. J. 2015, accepted (chem.201502522)
.
Biomedical: Graphene Oxide-Wrapped Gold
Nanorods
31. Sensing: Protein-Directed Synthesis of Highly
Fluorescent Gold Nanoclusters
Hu, L.; Deng, L.; Alsaiari, S.; Zhang, D.; Khashab, N. M. Anal. Chem., 2014, 86, 4989–4994.
32. Sensing: Protein-Directed Synthesis of Highly
Fluorescent Gold Nanoclusters
Hu, L.; Deng, L.; Alsaiari, S.; Zhang, D.; Khashab, N. M. Anal. Chem., 2014, 86, 4989–4994.
33. Sensing: Protein-Directed Synthesis of Highly
Fluorescent Gold Nanoclusters
Hu, L.; Deng, L.; Alsaiari, S.; Zhang, D.; Khashab, N. M. Anal. Chem., 2014, 86, 4989–4994.
34. Sensing: Protein-Directed Synthesis of Highly
Fluorescent Gold Nanoclusters
Hu, L.; Deng, L.; Alsaiari, S.; Zhang, D.; Khashab, N. M. Anal. Chem., 2014, 86, 4989–4994.
35. Biomedical: Zippered Release from Polymer
Gated Carbon Nanotubes
!
Mashat, A.; Deng, L; Altawashi, A.; Sougrat, R.; Wang, G.; Khashab, N. M. * “Zippered Release from Polymer Gated
Carbon Nanotubes” J. Mater. Chem. 2012, 22, 11503–11508.
General Scheme
36. Biomedical: Zippered Release from Polymer
Gated Carbon Nanotubes
Mashat, A.; Deng, L; Altawashi, A.; Sougrat, R.; Wang, G.; Khashab, N. M. * “Zippered Release from Polymer Gated
Carbon Nanotubes” J. Mater. Chem. 2012, 22, 11503–11508.
!
37. Chen, Ye; Tao, Jing; Deng, Lin; Li, Liang; Li, Jun; Yang, Yang; Khashab, N. M.* ACS App. Mater. Inter. 2013, 5, 7478–
7484. .
Composites: PEI/Bucky Gels Nanocomposites
with Superior Conductivity and Thermal Stability
!
General Scheme
38. Chen, Ye; Tao, Jing; Deng, Lin; Li, Liang; Li, Jun; Yang, Yang; Khashab, N. M.* ACS App. Mater. Inter. 2013, 5, 7478–7484.
Composites: PEI/Bucky Gels Nanocomposites
with Superior Conductivity and Thermal Stability
!
39. Chen, Ye; Tao, Jing; Song, Li; Khashab, N. M. * ACS App. Mater. Inter. 2014, 6, 9013–9022.
Composites: Polyfluorene Wrapped Carbon
nanotubes for Enhanced Interfacial Interactions
General Scheme
40. Chen, Ye; Tao, Jing; Song, Li; Khashab, N. M. * ACS App. Mater. Inter. 2014, 6, 9013–9022.
Composites: Polyfluorene Wrapped Carbon
nanotubes for Enhanced Interfacial Interactions
41. Composites: Surface Modification of Multiwall Carbon
Nanotubes with Cationic Conjugated Polyelectrolytes
General Scheme
Ezzeddine, A.; Chen, Z.; Schanze, K. S.; Khashab, N. M. ACS Appl. Mater. Interfaces, 2015, 7 , 12903–12913.
42. Composites: Surface Modification of Multiwall Carbon
Nanotubes with Cationic Conjugated Polyelectrolytes
Ezzeddine, A.; Chen, Z.; Schanze, K. S.; Khashab, N. M. ACS Appl. Mater. Interfaces, 2015, 7 , 12903–12913.
43. KAUST
on
the
Red
Sea
Spring 2016 internships and graduate students
Applications
are now open for submission
http://visitingstudent.kaust.edu.sa/Pages/Home.aspx
Niveen.khashab@kaust.edu.sa