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Class autonomic NERVOUS SYSTEM

THIS CLASS IS IN BRIEF FOR UNDERGRADUATE EXAMINATION AND UNDERSTANDING PURPOSE

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Class autonomic NERVOUS SYSTEM

  1. 1. Dr. RAGHU PRASADA M S MBBS,MD ASSISTANT PROFESSOR DEPT. OF PHARMACOLOGY SSIMS & RC. 1
  2. 2.  Central Nervous System (CNS) - Brain and spinal cord  Peripheral Nervous System (PNS) - Located outside the brain & spinal cord Autonomic Nervous System (ANS) & the somatic  The PNS receives stimuli from the CNS & initiates responses to the stimuli after it’s interpreted by the brain
  3. 3.  Parasympathetic Nervous Systemcholinergic  Sympathetic Nervous SystemAdrenergic  Enteric Nervous System ENS both
  4. 4. Acetylcholine –preganglionic Post ganglionic Ach Exception-post ganglionic sympathetic fibres to apocrine glands Cholinergic fibres All somatic motar neurons All preganglionic fibres Post ganglionic parasympathetic fibres
  5. 5. ADRENERGICR ECEPTOR LOCATION BETA 1 RECEPTOR BETA2 RECEPTOR BETA 3 RECEPTOR LOCATION HEART AND JG CELLS IN KIDNEY B-BRONCHI BLOOD VESSELS U-UTERUS, URINARY TRACT, L-LIVER G-GIT EYE ADIPOSE TISSUE SELECTIVE AGONIST DOBUTAMINE SALBUTAMOL, TERBUTALINE BRL SELECTIVE ANTAGONIST METAPROLOL ATENOLOL BUTOXAMINE CYANOPINDOLOL POTENCY OF NA AS AGONIST MODERATE WEAK STRONG
  6. 6. ADRENERGIC RECEPTOR ALFA 1 ALFA2 LOCATION POST JUNCTIONAL ON EFFECTOR ORGANS PREJUNCTIONAL ON NERVE ENDINGS , ALSO POST-J UNCTIONAL IN BRAIN, PANCREATIC BETA CELLS AND EXTRA JUNCTIONAL IN BLOOD VESSELS, PLATELETS FUNCTION GI SMOOTH MUSCLES- CONTRACTION GLAND-SECRETION GUT- RELAXATION LIVER-GLYCOGENESIS HEART-ARRHYTHMIAS INHIBITION OF TRANSMITTER RELEASE VASOCONSTRICTION DECREASED SYMPATHETIC FLOW DECREASED INSULIN RELEASE PLATELET AGGREGATION SELECTIVE AGONIST PHENYLEPHRINE METHOXAMINE CLONIDINE SELECTIVE ANTAGONIST PRAZOCIN, TERAZOCIN TAMSULOSIN YOHIMBINE, ROUWOLCINE EFFECTIVE PATHWAY IP3/DAG, PHOSHOLIPASE A2 CAMP K+ channel, Ca CHANNEL, IP3 /DAG
  7. 7. PARASYMPATHETIC RECEPTOR LOCATION AGONIST ANTAGONIST NN GANGLIA , ADRENAL MEDULLA NICOTINE ANATOXIN TRIMETHAPHAN ALFA BUNGAROTIXIN MECAMYLAMINE NM NEUROMUSCULAR JUNCTION NICOTINE EPIBATIDINE TUBOCURARINE m1 GASTRIC GLANDS, AUTONOMIC GANGLIA AND CNS OXOTRIMORINE PIRENZEPINE TELENZEPINE m2 HEART METHACHOLINE METHOCTRAMINE TRIPITRAMINE m3 SMOOTH MUSCLES, GLANDS, ENDOTHELIUM BETHANECHOL DARIFENACIN TOLTERIDINE HEXAHYDROSILDEN AFIL
  8. 8. Homotropic receptor interaction Heterotropic receptor interaction
  9. 9. Purines –ATP, adenosine NO-nitric oxide Endothelin Vascular homeostasis
  10. 10. THANKYOU Download slides from Authorstream-raghuprasada Slideshare-raghuprasada Youtube-raghuprasada

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