THIS CLASS IS IN BRIEF FOR UNDERGRADUATE EXAMINATION AND UNDERSTANDING PURPOSE

1. Dr. RAGHU PRASADA M S
MBBS,MD
ASSISTANT PROFESSOR
DEPT. OF PHARMACOLOGY
SSIMS & RC.
1

2.  Central Nervous System (CNS) - Brain and spinal
cord
 Peripheral Nervous System (PNS) - Located
outside the brain & spinal cord Autonomic
Nervous System (ANS) & the somatic
 The PNS receives stimuli from the CNS & initiates
responses to the stimuli after it’s interpreted by the
brain

4.  Parasympathetic Nervous Systemcholinergic
 Sympathetic Nervous SystemAdrenergic
 Enteric Nervous System ENS both

7. Acetylcholine –preganglionic
Post ganglionic Ach
Exception-post ganglionic sympathetic fibres to
apocrine glands
Cholinergic fibres
All somatic motar neurons
All preganglionic fibres
Post ganglionic parasympathetic fibres

9. ADRENERGICR
ECEPTOR
LOCATION
BETA 1
RECEPTOR
BETA2 RECEPTOR BETA 3 RECEPTOR
LOCATION HEART AND
JG CELLS IN
KIDNEY
B-BRONCHI
BLOOD VESSELS
U-UTERUS, URINARY TRACT,
L-LIVER
G-GIT
EYE
ADIPOSE TISSUE
SELECTIVE
AGONIST
DOBUTAMINE SALBUTAMOL,
TERBUTALINE
BRL
SELECTIVE
ANTAGONIST
METAPROLOL
ATENOLOL
BUTOXAMINE CYANOPINDOLOL
POTENCY OF
NA AS
AGONIST
MODERATE WEAK STRONG

10. ADRENERGIC
RECEPTOR
ALFA 1 ALFA2
LOCATION POST JUNCTIONAL ON
EFFECTOR ORGANS
PREJUNCTIONAL ON NERVE ENDINGS ,
ALSO POST-J UNCTIONAL IN BRAIN,
PANCREATIC BETA CELLS AND EXTRA
JUNCTIONAL IN BLOOD VESSELS,
PLATELETS
FUNCTION GI SMOOTH MUSCLES-
CONTRACTION
GLAND-SECRETION
GUT- RELAXATION
LIVER-GLYCOGENESIS
HEART-ARRHYTHMIAS
INHIBITION OF TRANSMITTER RELEASE
VASOCONSTRICTION
DECREASED SYMPATHETIC FLOW
DECREASED INSULIN RELEASE
PLATELET AGGREGATION
SELECTIVE
AGONIST
PHENYLEPHRINE
METHOXAMINE
CLONIDINE
SELECTIVE
ANTAGONIST
PRAZOCIN, TERAZOCIN
TAMSULOSIN
YOHIMBINE, ROUWOLCINE
EFFECTIVE
PATHWAY
IP3/DAG, PHOSHOLIPASE
A2
CAMP
K+ channel, Ca CHANNEL, IP3 /DAG

11. PARASYMPATHETIC
RECEPTOR
LOCATION AGONIST ANTAGONIST
NN GANGLIA , ADRENAL
MEDULLA
NICOTINE
ANATOXIN
TRIMETHAPHAN
ALFA
BUNGAROTIXIN
MECAMYLAMINE
NM NEUROMUSCULAR
JUNCTION
NICOTINE
EPIBATIDINE
TUBOCURARINE
m1 GASTRIC GLANDS,
AUTONOMIC
GANGLIA AND CNS
OXOTRIMORINE PIRENZEPINE
TELENZEPINE
m2 HEART METHACHOLINE METHOCTRAMINE
TRIPITRAMINE
m3 SMOOTH MUSCLES,
GLANDS,
ENDOTHELIUM
BETHANECHOL DARIFENACIN
TOLTERIDINE
HEXAHYDROSILDEN
AFIL

13. Homotropic receptor interaction
Heterotropic receptor interaction

14. Purines –ATP, adenosine
NO-nitric oxide
Endothelin
Vascular homeostasis

15. THANKYOU
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