The document discusses the World Health Organization's Biological Standardization Programme, which develops recommendations, guidelines, and international biological standards and reference reagents. It outlines the history of standardization beginning in the early 1900s with diphtheria antitoxin and insulin. The challenges of standardizing complex biological materials are discussed. Key organizations involved in biological standardization through the WHO are also named.

1. World Health Organization International Biological Standards Elwyn Griffiths Biologics and Genetic Therapies Directorate

41. Calibration of the current International Reference Preparation for TSH Deviation of any assay result from the mean is composed of two elements; the assay imprecision, and the bias: The WHO multi-method approach, by including all assays, seeks to average out, and therefore eliminate the bias effect. The WHO approach will provide an estimate which is “accurate” but not “ precise” The “reference-method approach will provide an estimate which may be “precise”, but not “ accurate” Method bias, and single method vs multi method calibration

45. Drift in the HBsAg “ng”