The document summarizes several issues encountered with high load on Alibaba MySQL databases and solutions implemented: 1) Hotspot updating of a single row caused deadlocks; implementing queueing on the primary key resolved this. 2) Unexpected long transactions under high load led to clients waiting long periods; committing transactions early where possible addressed this. 3) More than 50,000 active threads overwhelmed MySQL's capabilities; implementing actions based on low and high thread thresholds helped.