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Traquilizers

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Traquilizers

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Tranquilizers-Chlorpromazine*, Prochlorperazine, Trifluoperazine, Thiothixene, Haloperiodol*,
Triperiodol, Oxypertine, Chlordizepoxide, Diazepam*, Lorazepam, Meprobamate.

Tranquilizers-Chlorpromazine*, Prochlorperazine, Trifluoperazine, Thiothixene, Haloperiodol*,
Triperiodol, Oxypertine, Chlordizepoxide, Diazepam*, Lorazepam, Meprobamate.

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Traquilizers

  1. 1. Mr. Pankaj Kusum Ramdas Khuspe M. Pharmacy TRANQUILIZERS
  2. 2. LEARNING OBJECTIVES ©Mr. Pankaj Kusum Ramdas Khuspe Upon Completion of the chapter Student will; a. Understand the definition and classification of Tranquilizers. b. Recall and Rewrite the structure of Haloperidol, Chlorpromazine, Diazepam* c. Able to rewrite the properties and used of Tranquilizers. d. Examine various official preparation in market. e. Select the product as per brand names.
  3. 3. SYLLABUS 1. Chlorpromazine * 2. Haloperidol* 3. Diazepam* 4. Prochlorperazine 5. TrifluoPerazine 6. Thiothixene ©Mr. Pankaj Kusum Ramdas Khuspe 7. Triperidol 8. Oxypertine 9. Chlordiazepoxide 10. Lorazepam 11. Meprobamate
  4. 4. QUESTION BANK 1. Define and classify Tranquilizers.(4M) 2. Classify Tranquilizers . Also give the structure of diazepam with chemical name. (4M) 3. What are tranquilizers? Draw structure and write the chemical name and brand names of Diazepam. (3M) 4. Give structures and IUPAC (chemical) name, properties and uses of chlorpromazine or haloperidol. (3M) 5. Name a tranquilizer belonging to benzodiazepine class. Give its structure, chemical name and popular brand names.(3M) 6. What are tranquilizers? Write structure, give chemical name and popular trade name of Chlorpromazine.(3M) 7. Give structure, properties, stability, storage and uses of (3M) A. Lorazepam B. Triperidol C. Prochlorperazine ©Mr. Pankaj Kusum Ramdas Khuspe
  5. 5. DEFINITION  CNS depressants  which bring about  a calming effect and  induce a mild sedative effect. i.e. Tranquillizers are CNS depressants which bring about a calming effect and induce a mild sedative effect. E.g.: Haloperidol, Chlorpromazine etc ©Mr. Pankaj Kusum Ramdas Khuspe
  6. 6. TRANQUILIZERS These are CNS depressants agents. This bring about a calming effect and induce a mild sedative effect. They may cause some drowsiness but tolerance soon develops to this effect. These are the agents or drugs which reduce anxiety, induce mental repose, and Suppress agitation without significantly diminishing mental alacrity, ©Mr. Pankaj Kusum Ramdas Khuspe
  7. 7. ©Mr. Pankaj Kusum Ramdas Khuspe Major Tranquilizers or Antipsychotics • Chlorpromazine, Pochlorperazine, Phenothiazines • Haloperidol, Trifluperidol Butyrophenones • Reserpine Rauwolfia Alkloid • Thioxanthenes, Oxypertine. Others Minor Tranquilizers • Diazepam, Lorazepam, Nitrazepam Benzodiazepines • Meprobamate Carbamate • Hydroxyzine lithium carbonate Miscellaneous ©Mr. Pankaj Kusum Ramdas Khuspe CLASSIFICATION-I
  8. 8. ©Mr. Pankaj Kusum Ramdas Khuspe 1. Phenothiazine derivatives and related tricyclic compounds • Chlorpromazine, Trifluroperazine a. Phenothiazine derivatives • Chlorprothixene, Fluepenthixol b. Thioxanthenes • Haloperidol, Trifluoperidol 2. Butyrophenones • Clozapine 3.Dibenzodiazepines • Sulpiride 4.Benzamides and salicylamides • Pimozide 5. Diphenylbutyl piperdine derivatives • Reserpine 6. Miscellaneous: ©Mr. Pankaj Kusum Ramdas Khuspe CLASSIFICATION-II
  9. 9. CHLORPROMAZINE ©Mr. Pankaj Kusum Ramdas Khuspe 2-chloro-10-(3-dimethylaminopropyl)phenothiazine
  10. 10. ©Mr. Pankaj Kusum Ramdas Khuspe 2-chloro-10-(3- dimethylaminopropyl)phenothiazine
  11. 11. CHLORPROMAZINE ©Mr. Pankaj Kusum Ramdas Khuspe Phenothiazi ne Chloro Dimethyl amino Propyl
  12. 12. CHLORPROMAZINE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white or cream colored crystalline powder. 2. It is slight odor. 3. It is very less soluble in water. 4. It is freely soluble in alcohol. 5. It affected by light. Storage: It should be stored in well closed light resistant container at cool place away from direct sunlight.
  13. 13. CHLORPROMAZINE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as tranquilizers. 2. It is used to treat a. Schizophrenia b. Mania and hypomania c. Agitation associated with functional or organic psychosis. 3. It is used to control nausea and vomiting. 4. It is used to produce pre and post operative sedation. 5. It is rarely used as vasodilator. 6. It also used to reduces salivary and gastric secretion Official preparation: # Chlorpromazine I.P, B.P, U.S.P # Chlorpromazine tablet I.P, B.P, # Chlorpromazine elixir I.P, B.P, # Chlorpromazine injection I.P, B.P, # Chlorpromazine suppositories I.P Brand Names:
  14. 14. HALOPERIDOL ©Mr. Pankaj Kusum Ramdas Khuspe 4-[4-(4-Chlorophenyl)-4-hydroxy piperidino]-4- fluoro butyrophenone
  15. 15. HALOPERIDOL ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It occurs as a white to faintly yellowish coloured amorphous powder or microcrystalline powder. 2. It is odourless. 3. It is tasteless. 4. It is slightly soluble in water. 5. It is freely soluble in chloroform, acetone, benzene and methanol. Storage conditions: It should be stored in well closed container at cool place away from direct sunlight.
  16. 16. HALOPERIDOL ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as major tranquilizer. 2. It is used to treat a) Acute schizophrenia. b) Mania and hypomania. c) Behavioral disturbances. d) Severe anxiety. e) Childhood development disorders f) Attention-Deficit Hyperactivity Disorder (ADHD) in pediatrics. 3. It is used as anti emetics. 4. It is used to treat intractable disorders.
  17. 17. HALOPERIDOL ©Mr. Pankaj Kusum Ramdas Khuspe Official preparation: # Haloperidol I.P, B.P, U.S.P # Haloperidol tablets I.P, B.P # Haloperidol syrup I.P, B.P # Haloperidol injection I.P, B.P # Haloperidol suspension I.P, B.P # Haloperidol elixir I.P, B.P Brand name: Serenacc, Relinasc, Hexidol, and Estidol.
  18. 18. DIAZEPAM ©Mr. Pankaj Kusum Ramdas Khuspe Chloro-1, 3-dihydro-1-methyl-5-phenyl-2H-1,4- benzodiazepin 2- one.
  19. 19. DIAZEPAM ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is occurs as a white or pale yellow crystalline powder. 2. It is odourless. 3. It is tasteless at first followed by bitter taste. 4. It is sparingly soluble water, soluble in alcohol. 5. It is affected by light and moisture. Storage conditions: It should be stored in well closed light resistant air tight container at cool place away from direct sunlight.
  20. 20. DIAZEPAM ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as major tranquilizers. 2. It is used management of anxiety and tension states. 3. It is used for management of acute alcoholic withdrawal. 4. It is used as an adjunct for relief of skeletal muscle spasm. 5. It is used a. To treat epilepsy. b. To produce sedation. c. To treat excitation states. d. To premedication for surgical procedures.
  21. 21. DIAZEPAM ©Mr. Pankaj Kusum Ramdas Khuspe Official preparation: # Diazepam I.P, B.P, U.S.P # Diazepam Tablet I.P, B.P # Diazepam Capsule I.P, B.P # Diazepam rectal Solution I.P, B.P # Diazepam Gel I.P, B.P # Diazepam Elixir I.P, B.P Brand name: Calmpose, Valium, Placidox, Anaxol, Quietal, Diazewok, Zepose, Microdep
  22. 22. PROCHLORPERAZINE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white to pale yellow crystalline powder. 2. It is odourless. 3. It has a slightly bitter taste. 4. It is very slightly soluble in water and in alcohol 5. It is affected by light Storage: It should be stored in well closed light resistant container at cool place away from direct sunlight.
  23. 23. PROCHLORPERAZINE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as anti tranquilizers. 2. It is used to control nausea and vomiting. 3. It is a vasodilator and brings about reduction in blood pressure. 4. It also reduces salivary and gastric secretion. 5. It has local anesthetic property. 6. It is used to treat a. Schizophrenia b. Mania and Hypomania c. Agitation associated with functional or organic psychosis.
  24. 24. PROCHLORPERAZINE ©Mr. Pankaj Kusum Ramdas Khuspe Official preparation: # Prochlorperazine I.P, B.P, U.S.P #Prochlorperazine tablets. I.P, B.P, #Prochlorperazine capsule I.P, B.P, Brand name: Mentil, Stemetil
  25. 25. TRIFLUOPERAZINE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white to pale yellow crystalline powder. 2. It is odourless 3. It has a bitter taste. 4. It is hygroscopic. 5. It is freely soluble in water. Storage: It should be stored in well closed light resistant air tight container at cool place away from direct sunlight.
  26. 26. TRIFLUOPERAZINE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as tranquilizers. 2. It is used to control nausea and vomiting. 3. It is used to produce pre- and post-operative sedation. 4. It enhances the effects of barbiturates and analgesics. 5. It is a vasodilator and brings about reduction in blood pressure. 6. It is used to treat a. Schizophrenia b. Mania and Hypomania c. Agitation associated with functional or organic
  27. 27. TRIFLUOPERAZINE ©Mr. Pankaj Kusum Ramdas Khuspe Official preparation: # Trifluoperazine I.P, B.P, U.S.P #Trifluoperazine tablets I.P, B.P, # Trifluoperazine capsules I.P, B.P, U.S.P # Trifluoperazine injections. B.P, U.S.P Brand name:  Stelabid, Eskazine, Siquil.
  28. 28. THIOTHIXENE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white crystalline powder. 2. It is odorless 3. It has a bitter taste. 4. It is hygroscopic. 5. It is freely soluble in water. Storage: It should be stored in well closed light resistant air tight container at cool place away from direct sunlight.
  29. 29. THIOTHIXENE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as tranquilizers. Official preparation: # Thiothixene I.P, B.P Brand name:  Navane,thiothixene
  30. 30. TRIPERIDOL (TRIFLUPERIDOL) ©Mr. Pankaj Kusum Ramdas Khuspe Properties:  It is a white or vellowish white crystalline powder,  It is odourless.  It is tasteless.  It is practically insoluble in water. Storage: It should be stored in well closed container at cool place away from direct sunlight.
  31. 31. TRIPERIDOL ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as tranquilizer. 2. It is used to treat a) Acute schizophrenia. b) Mania and hypomania. c) Childhood development disorders 3. It is used as anti emetics. 4. It is used to treat intractable disorders. Official preparation: # Triperidol I.P, B.P, U.S.P # Triperidol tablets I.P, B.P Brand name:  Triperidol
  32. 32. CHLORDIAZEPOXIDE ©Mr. Pankaj Kusum Ramdas Khuspe Properties:  It is a white crystalline powder.  It has slight odour and a  It is having very bitter taste.  It is soluble in water.  It is affected by air, moisture and sunlight. Storage: It should be stored in well closed light resistant air tight container at cool place away from direct sunlight.
  33. 33. CHLORDIAZEPOXIDE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as tranquilizer. 2. It is used to get symptomatic relief during acute alcohol withdrawal. 3. It is also used as premedication in anaesthesia. 4. It is used to treat a. Symptoms of anxiety. (ii) b. Psychosomatic disorders. (iii) c. Insomnia associated with anxiety. d. Muscle spasm (due to muscle relaxant property).
  34. 34. CHLORDIAZEPOXIDE ©Mr. Pankaj Kusum Ramdas Khuspe Official preparation: # Chlordiazepoxide tablets I.P, B.P, U.S.P # Chlordiazepoxide tablets I.P, B.P, #Chlordiazepoxide hydrochloride injection. I.P, B.P Brand name:  Tropium, Librium
  35. 35. LORAZEPAM ©Mr. Pankaj Kusum Ramdas Khuspe Properties:  It is a white to off white powder.  It is odourless or almost odourless.  Ii is practically insoluble in water.  It is slightly soluble in alcohol, Storage: It should be stored in well closed container at cool place away from direct sunlight.
  36. 36. LORAZEPAM ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as tranquilizer. 2. It is used to treat a. (i) anxiety states b. insomnia associated with anxiety c. epileptic seizures (intravenously for rapid effect) 3. It is used for premedication a. before dental or general surgery b. before investigative procedures, when there may be discomfort.
  37. 37. LORAZEPAM ©Mr. Pankaj Kusum Ramdas Khuspe Official preparation: # Lorazepam I.P, B.P, U.S.P # Lorazepam tablets I.P, B.P # Lorazepam injection. I.P, B.P, Brand name:  Ativen, Lorapam, Alzapam
  38. 38. MEPROBAMATE ©Mr. Pankaj Kusum Ramdas Khuspe Properties:  It is a white crystalline powder or granular crystalline aggregate.  It is odouriess.  It has a bitter characteristic taste.  It is slightly soluble in water.  It is freely soluble in alcohol. Storage: It should be stored in well closed container at cool place away from direct sunlight.
  39. 39. MEPROBAMATE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as tranquilizer. 2. . It is used as an adjunct to treat tetanus. 3. It is used to treat : a. Psychoneurotic anxiety and tension states. b. Musculo-skeletal disorders (muscle spasm) due to its skeletal muscle relaxant property. c. Petitmal type of epilepsy.
  40. 40. MEPROBAMATE ©Mr. Pankaj Kusum Ramdas Khuspe Official preparation: # Meprobamate tablets # Meprobamate capsules I.P, B.P, U.S.P # Meprobamate injection I.P, B.P # Meprobamate oral suspension I.P, B.P Brand name:  Equanil, Cadiprom, PMT.
  41. 41. TRIPERIDOL (TRIFLUPERIDOL) ©Mr. Pankaj Kusum Ramdas Khuspe Properties:  It is a white or vellowish white crystalline powder,  It is odourless.  It is tasteless.  It is practically insoluble in water. Storage: It should be stored in well closed container at cool place away from direct sunlight.
  42. 42. TRIPERIDOL ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as tranquilizer. 2. It is used to treat a) Acute schizophrenia. b) Mania and hypomania. c) Childhood development disorders 3. It is used as anti emetics. 4. It is used to treat intractable disorders. Official preparation: # Triperidol I.P, B.P, U.S.P # Triperidol tablets I.P, B.P Brand name:  Triperidol
  43. 43. ©Mr. Pankaj Kusum Ramdas Khuspe Any question??? Thank you…

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