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Anti depressants

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Anti depressants

  1. 1. Mr. Pankaj Kusum Ramdas Khuspe M. Pharmacy ANTI-DEPRESSANTS THYMOLEPTICS
  2. 2. SYLLABUS Imperamine* Amitriptyline Nortryptyline Tranylcypromine Phenelzine
  3. 3. QUESTIONS 1. Define the Antidepressants with example 2. Define and classify Anti-depressants with examples. Draw structure of Imipramine. 3. Define Thymoleptics/Antidepressant. Give structure and uses of imipramine. 4. Draw structure and give chemical name & medicinal uses of Imipramine. 5. Define Anti-depressants. Give properties & uses of Amitryptyline.
  4. 4. DEFINITION drugs which counteract or overcome mental depression. These drugs are therapeutically useful in a variety of cases pertaining to mentally ill patients. “Antidepressants are drugs which counteract or overcome mental depression. These drugs are therapeutically useful in a variety of cases pertaining to mentally ill patients.”
  5. 5. DEFINITION drugs which counteract or overcome  mental depression. E.g. Imipramine, Amitriptyline “Antidepressants are drugs which counteract or overcome mental depression.” E.g. Imipramine, Amitriptyline,
  6. 6. CLASSIFICATION 1. Beta phenyl ethyl amine analogue: Phenelzine Isocarboxid, 2. Tricyclic antidepressants a. Dibenzazepine class: Imipramine b. Dibenzcycloheptene class: Amitriptyline, Nortriptyline 3. Selective serotonin reuptake inhibitors (SSRIs): Citalopream, Fluoxetine 4. Serotonin and Norepinephrine reuptake inhibitors (SNRIs): Venlafaxine, Desvenlafaxine 5. Atypical Antidepressants: Mitrazapine, Trazodone 6. Miscellaneous: Salbutamol,
  7. 7. IMIPRAMINE ©Mr. Pankaj Kusum Ramdas Khuspe 5-(3-Dimethylamino)propyl-10,11- dihydrodibenzoazepine
  8. 8. IMIPRAMINE ©Mr. Pankaj Kusum Ramdas Khuspe Propyl 10,11- dihydrodibenzoazepine N-dimethyl amino
  9. 9. IMIPRAMINE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white or slightly yellow colored crystalline powder 2. It is odorless. 3. It has slightly bitter taste. 4. It is very soluble in water. 5. It is freely soluble in alcohol. 6. It is affected by light and moisture Storage: It should be stored in well closed light resistance air tight container at a cool place away from direct sunlight.
  10. 10. IMIPRAMINE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as tricyclic antidepressant. 2. It is mainly used in the treatment of major depression. 3. It affects chemicals in the brain that may be unbalanced in people with depression. 4. It is used in the treatment of depression, such as depression associated with anxiety. 5. It is sometimes used to treat bed-wetting in children ages 6 and older. 6. It has marked sedative property Official preparation: # Imipramine I.P, B.P, U.S.P # Imipramine injection I.P, B.P, U.S.P # Imipramine tablet I.P, B.P, # Imipramine casule I.P, B.P, # Imipramine mixture I.P,
  11. 11. AMITRIPTYLINE (AMITRYPTYLINE) ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white powder. 2. It is odorless. 3. It is freely soluble in water, in ethanol (95%), in chloroform and in methanol. 4. It is practically insoluble in ether. Storage: It should be stored in well closed container at a cool place away from direct sunlight.
  12. 12. AMITRIPTYLINE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as Antidepressant. 2. It is used in treatment of mental depression. 3. It is also used in treatment of a. Nocturnal enuresis in children. b. Anxiety c. Chronic tension headache. d. Endogenous depression. Official preparation: # Amitriptyline I.P, B.P, U.S.P # Amitriptyline tablet I.P, B.P # Amitriptyline Injection I.P, B.P Brand Names: Amitrip, Tryptanol
  13. 13. NORTRYPTYLINE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white powder. 2. It is odorless. 3. It is sparingly soluble in water. 4. It is freely soluble in ethanol, chloroform and methanol. 5. It is practically insoluble in ether. 6. It is affected by light. Storage: It should be stored in well closed light resistant container at a cool place away from direct sunlight.
  14. 14. NORTRYPTYLINE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as Antidepressant. 2. It is used in treatment of mental depression. 3. It is also used in treatment of a. Nocturnal enuresis in children. b. Anxiety Official preparation: # Nortryptyline I.P, B.P, U.S.P # Nortryptyline Capsule I.P, B.P, U.S.P # Nortryptyline Tablet I.P, B.P, U.S.P Brand Names: Primox, Sensival
  15. 15. TRANYLCYPROMINE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white crystalline powder. 2. It is odorless. 3. It has a acid like taste. 4. It is soluble in water and in alcohol. 5. It is affected by light. Storage: It should be stored in well closed container at a cool place away from direct sunlight.
  16. 16. TRANYLCYPROMINE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as Antidepressant. 2. It is used in treatment of a. Nocturnal enuresis in children. b. Anxiety Official preparation: # Tranylcypromine I.P, B.P, U.S.P # Tranylcypromine tablet I.P, B.P, Brand Names: Parnate, Parstelline
  17. 17. PHENELZINE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white crystalline powder. 2. It is pungent odor. 3. It has a bitter taste. 4. It is very soluble in water. 5. It is slightly soluble in alcohol. 6. It is affected by air & light Storage: It should be stored in well closed light resistant air tight container at a cool place away from direct sunlight.
  18. 18. PHENELZINE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as Antidepressant. 2. It is used in treatment of a. Nocturnal enuresis in children. b. Anxiety. c. Phobic states. d. Obsessive disorder. Official preparation: # Phepelzine I.P, B.P, U.S.P # Phepelzine tablet I.P, B.P, U.S.P Brand Names: Nordil
  19. 19. Any Question??? Thank you...

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