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Anti cholinergic agent

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Anti cholinergic agent

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Adrenergic Drugs-Adrenaline*, Noradrenaline, Isoprenaline*, Phenylephrine Salbutamol, Terbutaline, Ephedrine *, Pseudoephedrine.
Adrenergic Antagoinst-Tolazoline, Propranolol*, Practolol.
Cholinergic Drugs-Neostigmine*,Pyridostigmine, Pralidoxime, Pilocarpine, Physostigmine*.
Cholinergic Antagonists-Atropine*, Hysocine, Homatropine, Propantheline*, Benztrophine, Tropicamide, Biperiden.*

Adrenergic Drugs-Adrenaline*, Noradrenaline, Isoprenaline*, Phenylephrine Salbutamol, Terbutaline, Ephedrine *, Pseudoephedrine.
Adrenergic Antagoinst-Tolazoline, Propranolol*, Practolol.
Cholinergic Drugs-Neostigmine*,Pyridostigmine, Pralidoxime, Pilocarpine, Physostigmine*.
Cholinergic Antagonists-Atropine*, Hysocine, Homatropine, Propantheline*, Benztrophine, Tropicamide, Biperiden.*

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Anti cholinergic agent

  1. 1. Mr. Pankaj Kusum Ramdas Khuspe M. Pharmacy ANTI- CHOLINERGIC DRUGS PARASYMPATHOLYTICS
  2. 2. SYLLABUS Atropine* Homatropine Hyoscine Propantheline* Biperiden* Benztropine Tropicamide
  3. 3. QUESTION 1. Give properties, therapeutic uses and official preparations of Atropine. 2. Write the structure and uses of Atropine. 3. Give structure, properties and uses of Atropine. 4. Give uses & preparation Hyoscine. 5. Write structure of Propantheline bromide, give its chemical name, properties and uses.
  4. 4. DEFINITION substance or agent that reduces the activity of the parasympathetic nervous system. The substance or agent that reduces the activity of the parasympathetic nervous system are called as parasympatholytic agent or Anti cholinergic agent. E.g.: Atropine, Propantheline, Biperiden
  5. 5. DEFINITION substance or agent that inhibit the activity of the acetyl choline. The substance or agent that inhibit the activity of the acetyl choline are called as parasympatholytic agent or Anti cholinergic agent. E.g.: Atropine, Propantheline, Biperiden
  6. 6. CLASSIFICATION 1. Aminoalcohol esters a) Solanaceous alkaloids and synthetic analogues: Atropine, Hyoscine b) Synthetic compounds: Propantheline 2. Amino alcohol ethers: Benzotropine 3. Amino alcohols: Biperiden 4. Amino amides: Tropicamide 5. Miscellaneous: Pirenzepine
  7. 7. ATROPINE ©Mr. Pankaj Kusum Ramdas Khuspe (8 - methyl - 8 - azabicyclo [ 3.2.1 ] oct - 3 - yl ) 3 - hydroxyl - 2 - phenyl propanoate
  8. 8. ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white crystalline powder. 2. It is odorless. 3. It has bitter taste. 4. It is sparingly soluble in water. 5. It is freely soluble in chloroform Storage: It should be stored in well closed containers at cool place away from direct sunlight. ATROPINE
  9. 9. ATROPINE USES: 1. It is used as anti cholinergic agent. 2. It is used in treatment of a) In the treatment of Parkinsonism. b) Pylorospasm, hypertonicity of the small intestine and the hypermotility of the colon. c) Urinary tract disorders. d) Peptic ulcer. 3. To relieve hypertonicity of the uterine muscle. 4. To relax the spasm of biliary and bronchial spasm. 5. In anesthesia to control excessive salivation and bronchial secretions. 6. It used as an antidote for pilocarpine, physostigmine, isoflurophate, choline esters, certain species of ©Mr. Pankaj Kusum Ramdas Khuspe
  10. 10. ATROPINE ©Mr. Pankaj Kusum Ramdas Khuspe Official preparation: # Atropine I.P, B.P, U.S.P # Atropine injection I.P. B.P. # Atropine eye drops B.P. # Atropine eye ointment I.P., B.P. # Atropine sulphate tablets I.P. Brand Names: Eumydrin, Daturin, Atropen
  11. 11. HOMATROPINE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is occurs as colorless crystals 2. It is odorless 3. It has bitter taste. 4. It is freely soluble in water. Storage: It is stored in well closed container at a cool place away from direct sunlight.
  12. 12. HOMATROPINE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as anti cholinergic agent. 2. It is used in treatment of a) In the treatment of Parkinsonism. b) Pylorospasm, hypertonicity of the small intestine and the hypermotility of the colon. c) Treatment of urinary tract disorders. d) Peptic ulcer Official preparation: # Homatropine I.P, B.P, U.S.P # Homatropine methyl bromide tablet. I.P, B.P, # Homatropine ophthalmic solution. I.P, B.P Brand Names: Mydryn Eye, Spasmoverine.
  13. 13. HYOSCINE (Scopolamine) ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is occurs as white crystalline powder 2. It is odorless 3. It has bitter taste. 4. It is freely soluble in water. 5. It is affected by light and air. Storage: It is stored in well closed light resistant air tight container at a cool lace away from direct sunlight.
  14. 14. HYOSCINE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as anti cholinergic agent. 2. Rarely it is used to treat parkinsonism. 3. It is used as CNS depressant so used as; a. Sedative b. Prophylaxis against motion sickness. Official preparation: # Hyoscine . I.P, B.P, U.S.P # Hyoscine tablet. I.P # Hyoscine injection. I.P # Hyoscine Syrup I.P Brand Names: Antispas, Bellaphen
  15. 15. PROPANTHELINE ©Mr. Pankaj Kusum Ramdas Khuspe N,N-di-isopropyl-N-methyl-N-[2-(xanthene-9-yl carbonyloxy)ethyl]ammonium bromide
  16. 16. PROPANTHELINE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is occurs as white or yellowish white powder, 2. It is odorless. 3. It has very bitter taste. 4. It is Slightly hygroscopic. 5. It is soluble in water Storage: It is stored in well closed air tight containers at cool place away from direct sunlight.
  17. 17. PROPANTHELINE ©Mr. Pankaj Kusum Ramdas Khuspe USES: 1. To treat gastric and duodenal ulcers. 2. To treat intestinal hypermotility. 3. To reduce gastric secretion. 4. To produce reactive hypoglycemia (by stimulating insulin release). 5. To reduce biliary and uterine spasm. 6. To control excessive sweating and salivation. 7. To prevent nocturnal enuresis in children. Official preparation: # Propantheline I.P, B.P, U.S.P # Propantheline Tablet I.P, B.P # Propantheline Capsule I.P, B.P Brand Names: Profanthine, Propa, Prolinecare
  18. 18. BIPERIDINE ©Mr. Pankaj Kusum Ramdas Khuspe 1-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3- (1-piperidinyl)-1-propanol
  19. 19. ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white crystalline powder. 2. It has odorless. 3. It is having bitter taste. 4. It is slightly soluble in water. 5. It is freely soluble in chloroform. 6. It affected by light. Storage: It should be stored in well closed light resistant containers at cool place away from direct sunlight. BIPERIDINE
  20. 20. BIPERIDINE ©Mr. Pankaj Kusum Ramdas Khuspe USES: 1. It is used to treat all types of Parkinson's disease. 2. It treat pseudo parkinsonism. 3. To treat acute dystonic reaction. Official preparation: # Biperidine I.P, B.P, U.S.P # Biperidine Injection I.P, B.P, # Biperidine Tablet I.P, B.P, Brand Names: Akineton, Berofin, Biperen, Biperin, Kinex.
  21. 21. BENZTROPINE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white crystalline powder. 2. It is odourless. 3. It is having bitter taste. 4. It is very soluble in water. 5. It is freely soluble in alcohol. 6. It is slightly hygroscopic. Storage: It is stored in well closed air tight container at a cool lace away from direct sunlight.
  22. 22. BENZTROPINE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used to treat parkinsonism. 2. It has anti histaminic effect. 3. It is used to treat dyskinesia. 4. It is used in treatment of a) In the treatment of Parkinsonism. b) Pylorospasm. c) Urinary tract disorders. Official preparation: # Benzotropine I.P, B.P, U.S.P # Benzotropine injection I.P, B.P # Benzotropine tablet I.P, B.P Brand Names: Cogentin
  23. 23. TROPICAMIDE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white crystalline powder. 2. It has odorless. 3. It is having faintly bitter taste. 4. It is slightly soluble in water. 5. It is freely soluble in Chloroform. Storage: It should be stored in well closed container at a cool place away from direct sunlight.
  24. 24. TROPICAMIDE ©Mr. Pankaj Kusum Ramdas Khuspe USES: 1. It is used as mydriatics. 2. It is used in treatment of cycloplegia. Official preparation: # Tropicamide I.P, B.P, U.S.P # Tropicamide eye drops I.P, B.P Brand Names: Mydriacyl
  25. 25. Any Question??? Thank you...

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