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Anti adrenergic agent

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Anti adrenergic agent

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Adrenergic Drugs-Adrenaline*, Noradrenaline, Isoprenaline*, Phenylephrine Salbutamol, Terbutaline, Ephedrine *, Pseudoephedrine.
Adrenergic Antagoinst-Tolazoline, Propranolol*, Practolol.
Cholinergic Drugs-Neostigmine*,Pyridostigmine, Pralidoxime, Pilocarpine, Physostigmine*.
Cholinergic Antagonists-Atropine*, Hysocine, Homatropine, Propantheline*, Benztrophine, Tropicamide, Biperiden.*

Adrenergic Drugs-Adrenaline*, Noradrenaline, Isoprenaline*, Phenylephrine Salbutamol, Terbutaline, Ephedrine *, Pseudoephedrine.
Adrenergic Antagoinst-Tolazoline, Propranolol*, Practolol.
Cholinergic Drugs-Neostigmine*,Pyridostigmine, Pralidoxime, Pilocarpine, Physostigmine*.
Cholinergic Antagonists-Atropine*, Hysocine, Homatropine, Propantheline*, Benztrophine, Tropicamide, Biperiden.*

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Anti adrenergic agent

  1. 1. Mr. Pankaj Kusum Ramdas Khuspe M. Pharmacy ANTI -ADRENERGIC DRUGS ADRENERGIC ANTAGONIST SYMPATHOLYTICS
  2. 2. SYLLABUS Propranolol* Tolazoline, Practolol.
  3. 3. QUESTION 1. What are sympatholytics? Write structure and uses of propranolol. 2. Give structure and use of propranolol.
  4. 4. DEFINITION The drugs which block  response to endogenous or exogenous circulating epinephrine or which block response to adrenergic nerve stimulation or which prevent release of adrenergic transmitter substance at sympathetic nerve endings are called as Sympatholytic or antiadrenergic drugs. E.g.:Propranolol*, Tolazoline, Practolol.
  5. 5. DEFINITION The drugs which block response to endogenous or exogenous circulating epinephrine or which block response to adrenergic nerve stimulation or which prevent release of adrenergic transmitter substance at sympathetic nerve endings are called as Sympatholytic or anti-adrenergic drugs. E.g.:Propranolol*, Tolazoline, Practolol.
  6. 6. DEFINITION The drugs which block response of adrenergic nervous system by producing antagonistic affect are called as Sympatholytic or anti-adrenergic drugs. E.g.:Propranolol, Tolazoline, Practolol.
  7. 7. CLASSIFICATION 1. α-adrenergic blocker: - Tolazoline 2. ß-adrenergic blocker: 2a. Selective ß-adrenergic blocker: - Atenolol 2b. Non-Selective ß-adrenergic blocker: - Propanolol
  8. 8. PROPRANOLOL ©Mr. Pankaj Kusum Ramdas Khuspe 1-isopropylamino, 3(1-napthyloxy) 2- propanol
  9. 9. PROPRANOLOL ©Mr. Pankaj Kusum Ramdas Khuspe Isopropyl amino 2-Propanol 1-napthyloxy
  10. 10. PROPRANOLOL ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white crystalline powder. 2. It has odorless. 3. It is having slightly bitter taste. 4. It is very soluble in water. 5. It affected by light. Storage: It is stored in well closed light resistant containers at a cool place away from direct sunlight.
  11. 11. PROPRANOLOL ©Mr. Pankaj Kusum Ramdas Khuspe USES: 1. It is a used as beta adrenergic receptor blocker, used in the treatment of cardiac diseases and emergencies like a. Angina pectoris b. Cardiac arrhythmia c. Hypertension d. Congestive heart failure e. Myocardial infarction (MI), f. Coronary atherosclerosis 2. It is a used in treatment of Pheochromocytoma. 3. It is a used to reduce symptoms of anxiety such as sweating, tachycardia and diarrhoea, particularly in susceptible individuals prior to public speaking engagements or meetings etc
  12. 12. PROPRANOLOL ©Mr. Pankaj Kusum Ramdas Khuspe Official preparation: # Propranolol I.P, B.P, U.S.P # Propranolol tablet I.P, B.P # Propranolol injection I.P, B.P Brand Names: Ciplar, Procard
  13. 13. ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white or creamy white microcrystalline powder. 2. It has odorless. 3. It is having slightly bitter taste. 4. It is very soluble in water. 5. It is freely soluble in alcohol. 6. It affected by air. Storage: It is stored in well closed light resistant containers at a cool place away from direct sunlight. TOLAZOLINE
  14. 14. TOLAZOLINE ©Mr. Pankaj Kusum Ramdas Khuspe USES: 1. It is used as adrenergic antagonist. 2. It is used to treat peripheral vascular disorders and Reynaud's Disease. 3. It is also used as stimulant to gastric secretions. Official preparation: # Tolazoline I.P, B.P, U.S.P # Tolazoline tablet I.P, B.P, Brand Names: Priscol, Priscophen
  15. 15. PRACTOLOL ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white crystalline powder. 2. It is having bitter taste. 3. It is odorless. 4. It is slightly soluble in water. 5. It is affected by light. Storage: It is stored in well closed light resisstant container at a cool lace away from direct sunlight.
  16. 16. PRACTOLOL ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as adrenergic antagonist. 2. It is used to treat a) To treat hypertension. b) To treat cardiac arrthymia. Official preparation: # Practolol I.P, B.P, U.S.P # Practolol injection I.P, B.P Brand Names: Actifed
  17. 17. Any Question??? Thank you...

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