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Dr prerok regmi

Dr prerok regmi

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The review of literature to the two upavisa from classical text of Ayurveda were evaluated with relation to latest experimental results.

The review of literature to the two upavisa from classical text of Ayurveda were evaluated with relation to latest experimental results.

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Dr prerok regmi

  1. 1. Role of Upavisa in Infertility caused by drug dependence - Review study. Prerok Regmi 1, Ravikrishna S 2, Chaithra H3 . 1 PG Scholar, Agadatantra Department, SDM college of Ayurveda, Udupi, Karnataka, India 2Associate Professor, Agadatantra Department, SDM college of Ayurveda, Udupi, Karnataka, India 3 Professor and HOD, Agadatantra Department, SDM college of Ayurveda, Udupi, Karnataka, India
  2. 2. INTRODUCTION Upavisa (~subpoison) are listed in the schedule-E of Drugs and Cosmetics Act 1940. Drug dependence has been defined as a cluster of behavioral, cognitive and physiological phenomena that develop after repeated substance use. Chemical extract of alkaloids are used in medicinal purpose extensively. The major issue to those chemically extracted medicine is drug dependence leading to drug abuse. Impact of Drug abuse: Potent Upavisa are illegal in trade and commercial purpose.
  3. 3. Drug dependence changes in hormone levels that affect sperm movement and lead to infertility. Women had a slightly elevated risk for infertility due to an ovulatory abnormality due to substance use disorder.  Illicit drug use of anabolic-androgenic steroids, marijuana, opioid narcotics, cocaine etc. are mentioned major cause factor of infertility. Upavisa are added in different formulation for medicinal purpose after Sodhana procedure. This study aims to review two Upavisa with special reference to infertility & drug dependency.
  4. 4. METHODS: 1. The literature of Upavisa "Bhang“ and "Ahiphen" from classical text of Ayurveda were evaluated with relation to infertility. 2. Upavisa "Bhang“ and "Ahiphen" and their impact is searched in peer reviewed journal articles.
  5. 5. RESULTS: 1 • Ahiphena (Papaver somniferum linn ) : It is strength promoter and induces rejuvination (बल्यानि वृष्याणि ). Continuous use for the longer period causes impotency (मुहुमोहकरं रुच्यं सेविात्ुंस्ततविाशिम्) (Bhavprakash Nighantu) • Bhanga (Cannabis sativa): It overcomes the diseases/ or sufferings. In a small quantity, it improves fertility (ग्रहण्यमल््मात्रायां वृष्ययोगे युज्यत्) (Priya Nighantu).
  6. 6. RESULTS: 2 Pubmed (Morphine) AND Infertility N= 19 (Cannabis) AND Infertility N=27 (Upavisa) AND Infertility N = Number of search items. AND= Pubmed Boolean Operator
  7. 7. RESULTS Morphine (obtained from Ahiphene) alone induces anovulatory infertility due to hypothalamus-pituitary-ovary axis dysfunction. Combinational treatment of noscapine (opium alkaloids) and paclitaxel improve efficacy in human prostate cancer treatment. Morphine with Genistein administration increase the quality of spermatozoa and prevent morphine- induced adverse effects on sperm parameters.  Interrelations between the endocannabinoid system and the activity of the endocrine system showing therapeutic target proving effective on infertility treatment. (Borowska M, 2018) Papaver somniferum
  8. 8. Cannabidiol and cannabidivarin (natural cannabinoids of Cannabis) damage the genetic material, signaling interferes with trophoblast biology. Marijuana plays in disrupting the hypothalamus- pituitary-gonadal axis, spermatogenesis, and sperm function such as motility, capacitation, and the acrosome reaction. In combination of Melatonin and vitamin C ameliorate whereas exacerbate C. sativa-induced testicular damage when administered separately Cannabis sativa
  9. 9. DISCUSSION There is increase of the efficacy with addition of two or more compounds or Interrelations of endocannabinoid system. The extracted single chemical showing adverse effect causing infertility and drug dependency.  But in combination or formulation form, their effect is decreased and drug habituation is also minimum.
  10. 10. CONCLUSION • The use of the drugs in formulation or combination method as per Ayurveda is beneficial for prevention of infertility caused by drug dependence or infertility due to other causes. • Prioritization of toxin reduction by Shodhan in comparison to extraction & addition of the complementary ingredients. • Promoting drugs Legal Framer- Pharma-Patient networking THANK YOU !!!

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