Basic Civil Engineering first year Notes- Chapter 4 Building.pptx
Measles surveillance sepio mtg 18 20 may 2011 (ab) v1
1. Measles: Disease, epidemiology and surveillance: Data for Action Dr A S Bose, WHO Workshop on Immunization Programme, GoI Hotel Royal Plaza, New Delhi 19 May 2011
5. Clinical course of measles Incubation period ( 7–18 days before rash) 18 days before rash Exposure happened the earliest 18 days before rash 4 days before rash Is the probable start of infectiousness Prodrome (about 4 days) -18 -17 -16 -15 -14 -13 -12 -11 -10 -9 -8 -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7 8 4 days after rash Is the probable end of infectiousness Rash (about 4–8 days) RASH The case can be identified here
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7. Measles complications Corneal scarring causing blindness Vitamin A deficiency (Common) Encephalitis Older children, adults ≈ 0.1% of cases Chronic disability Pneumonia & Diarrhea (Common) Diarrhea common in developing countries Pneumonia ~ 5-10% of cases, usually bacterial desquamation
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11. Measles control strategies *GIVS target > 90% nationally, > 80% in every district Case Management Surveillance 2 nd dose coverage (routine delivery or SIAs) 1 st dose coverage Vitamin A Supportive Rx Aggregate or case-based > 90%* > 90%* Mortality Reduction Vitamin A Supportive Rx Case-based > 95% > 95% Elimination
13. Measles vaccination valid coverage by 12 months of age, 2005 and 2010 Source: CES 2005 and 2010 2005 2010 81% (52/64) districts achieved ≥80% coverage in 2010
14. Impact of Measles Immunization Campaigns: Marked Reduction of Cases from Lab Confirmed Outbreaks Bangladesh, 2004-2010 (May) Source: Monthly case-based data up to May 2010 Accelerated Measles Surveillance
15. Lack of impact and resurgence of disease: WHO African Region When strategies are not implemented properly or not in a sustained manner
16. No. of reported measles cases and coverage with 1 st dose of measles containing vaccine (MCV1) in infants WHO African Region 2000-2010* *Source: Measles outbreaks and progress towards meeting measles pre-elimination goals: WHO African Region 2009-2010. [Editorial note] Weekly Epidemiological Record. No. 14 1 st April 2011
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19. India: Lab supported measles outbreak surveillance Linkage with program decisions
20. NPSP assisted Measles Surveillance 2006 (Surveillance initiated) 2007 (Surveillance initiated) 2010 (Surveillance initiated) 2009 (Surveillance initiated) Reporting of Clinical Measles cases linked with AFP weekly reporting in these states; Weekly aggregate data should be mutually shared with IDSP One state level lab strengthened in each state. Lab testing for measles and rubella IgM. 2011 2011 2011 2011 (Surveillance planned)
21. Scale-up of laboratory supported measles outbreak surveillance 2006 2007 2010 2009 2011 (Planned) Reporting of Clinical Measles cases linked with AFP weekly reporting in these states; Weekly aggregate data should be mutually shared with IDSP One state level lab strengthened in each state. Lab testing for measles and rubella IgM.
22. Serologically confirmed # measles, rubella and mixed outbreaks, India (Andhra Pradesh, Gujarat, Karnataka, Kerala, Madhya Pradesh, Rajasthan, Tamil Nadu and West Bengal) 216 outbreaks 68 56 41 196 16 4 2009 2010* 165 outbreaks # Outbreak confirmation for Measles: 2009 ≥ 1 cases IgM positive for measles, Similarly for Rubella Outbreak confirmation for Measles: 2010 ≥ 2 cases IgM positive for measles, Similarly for Rubella * data as on 15 th Apr, 2011 Widespread measles virus transmission Low coverage Districts in high coverage states Mixed outbreaks confirmed Rubella outbreaks confirmed Measles outbreaks confirmed
23. 2008 Total cases- 2118 2009 Total cases- 464 Measles cases by age, 2008-2011, Gujarat Cases from serologically confirmed measles and mixed outbreaks % % 2010 Total cases- 973 % 2011* Total cases- 710 % * data as on 15 th Apr, 2011
24. 2010* Total cases- 1453 Measles cases by age, 2008-2011, Madhya Pradesh % 2008 No reporting in 2008 Cases from serologically confirmed measles & mixed outbreaks No reporting in 2009 * data as on 15 th Apr, 2011 2009 2011* Total cases- 197 %
25. 2008 2011* Total cases- 349 Measles cases by age, 2008-2011, Rajasthan % 2009 No reporting in 2008 2010 Total cases- 1141 % Cases from serologically confirmed measles & mixed outbreaks * data as on 15 th Apr, 2011 Total cases- 293 %
26. N=213 Andhra Pradesh N=301 Gujarat N=363 Tamil Nadu N=686 Madhya Pradesh West Bengal N=705 Karnataka Measles cases (1-4 years) by vaccination status, 2010* N=517 Rajasthan N=680 Cases from serologically confirmed measles & mixed outbreaks N=227 Kerala * data as on 15 th Apr, 2011 Vaccinated Not Vaccinated Unknown
27. N=195 Andhra Pradesh N=457 Gujarat N=311 Tamil Nadu N=531 Madhya Pradesh N=649 West Bengal N=464 Karnataka Measles cases (5-9 years) by vaccination status, 2010* Cases from serologically confirmed measles outbreaks N=442 Rajasthan N=243 Kerala * data as on 15 th Apr, 2011 Vaccinated Not Vaccinated Unknown
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29. Total cases- 202 Outbreaks- 2 Total cases- 136 Outbreak- 1 Total cases- 189 Outbreaks- 2 2008 2010 2011 Measles cases by age, Bihar, 2008-2011* Cases from serologically confirmed measles outbreaks % % * data as on 15 th May, 2011 %
30. Serologically confirmed measles outbreaks – Bihar, 2008-2011* Vaccination status of measles cases by age N=22 N=219 N=235 N=37 N=14 1-4 years 5-9 years 10-14 years >=15 years < 1 year * data as on 15 th May, 2011 Vaccinated Not Vaccinated Unknown
31. Case Fatality Ratios in lab confirmed measles outbreaks: catch-up campaign states
36. Serologically confirmed # measles, rubella and mixed outbreaks, India (Andhra Pradesh, Gujarat, Karnataka, Kerala, Madhya Pradesh, Rajasthan, Tamil Nadu and West Bengal) 68 outbreaks 65 2 1 2011* # Outbreak confirmation for Measles: 2011 ≥ 2 cases IgM positive for measles, Similarly for Rubella * data as on 15 th Apr, 2011 Mixed outbreaks confirmed Rubella outbreaks confirmed Measles outbreaks confirmed
37. Measles case fatality ratio, Bihar, 2008-2011* * data as on 15 th May, 2011 3.04 527 16 Total 3.96 202 8 2011 0.00 189 0 2010 5.88 136 8 2008 Fatality rate Total Measles cases Total Measles Deaths Year
Editor's Notes
Corneal scarring Associated with vitamin A defiency Historically the most common cause of blindness in children in Africa, India Encephalitis: Older child more typically - High mortality rate Survivors high rate of disability as here Pneumonia & diarrhea: Pneumonia usually bacterial. Most common cause of post-measles death Note also the skin peeling, a characteristic sign of a healing measles rash
1. Vaccine does not contain a preservative Needs diluent from manufacturer – not saline, not sterile water, not tap water, etc.
This is the result of strengthening routine EPI in Bangladesh. As per the data of 2010 CES 52 of 64 district which is more than 80% had already reached > than 80% measles coverage. And the presented figures are valid coverage of children who vaccinated with the first dose before they reach one year of age.
Imm data: Biases = Recall bias (mostly from verbal recall in absence of imm cards) + Observer Bias as local ANM is often the data collector RJ = Failure to vaccinate; TN = Failure of 1 dose of vaccine.