A breakout session at the Pistoia Alliance Information Ecosystem Workshop proposed several midterm activities the Alliance could undertake, including ways to improve interactions between CROs and pharma. The workshop was held in October 2011

1. Mid-Term Projects
Information Ecosystem Workshop (PA)
10.10.11
Monday, 10 October 2011

2. People
• Henrik Seidel
• William Spooner
• Thomas Blackadar
• Ewan Hunter
• Bryn Williams-Jones
• Misha Kapushesky
Monday, 10 October 2011

3. Mid-Term Project Ideas
• Improving CRO-pharma interaction
• “Common language” tools for integration
• Physical shipping logistics
• Sequence services phase three
Monday, 10 October 2011

4. CRO-Pharma
Environment
• Problem: there are increased costs to
CROs and pharma in data round-tripping
over QC evaluation rounds
• Short-term Assumption: a common
standard can be defined for ELN data
interchange
Monday, 10 October 2011

5. CRO-Environment
Mid-Term Project
• Implementation of ELN interchange
standard
• Dev’p cloud environment for CRO/pharma
• Identity management and validation
• Timestamp, audit trails, verification
• Secure, validated, trusted (PA-approved)
Monday, 10 October 2011

6. CRO-Environment
Beyond Mid-Term
• Standard for protocol reporting with implementation and
servicing
• Look for funding from PA and consider CROs, ELN
developers as stakeholders
• ROI
• Better data quality
• Clearer IP ownership
• Lower total cost
• Improve quality control and reproducibility
Monday, 10 October 2011

7. “Common Language” Tools
Mid-Term Project
• Problem: there is no trusted resource for
unambiguous resolution of named entities
• Short-term Assumption: an identifier
mapping service will be created
Monday, 10 October 2011

8. “Common Language” Tools
Mid-Term Project
• Why? To enable data integration, “disease
explorer”-like use cases
• A canonical, trusted, PA-approved
repository of vocabularies/ontologies
• Collaborative ontology hosting,
development and maintenance environment
Monday, 10 October 2011

9. “Common Language” Tools
Mid-Term Project
• Tools for annotation, tagging and integration of
canonical ontologies/vocabularies into QC
pipelines, ELN, LIMS, DBs and other systems
• Roles for Pistoia:
• Selection, approval: eg animal models ontol’s
• bring together key stakeholders in academia
and industry to result in an SME, non-profit, or
a workgroup to help build and maintain service
and tools
Monday, 10 October 2011

10. Physical Shipping
Logistics
• Chemicals shipping: standards for labelling,
pre- and post-shipping quality control,
tracking, servicing
• Workgroup to mandate and approve
standards, best practices
Monday, 10 October 2011

11. Seq Services Phase 3
• Expanding tools and data types
• Expanding to sensitive data: patients, clinical
• Translational applications
• Healthcare
Monday, 10 October 2011