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Proportion of IgE-Mediated Allergic Reactions to the 2009-2010 pH1N1 Vaccine
1.
Proportion of IgE-mediated
allergic reactions to the 2009-2010 pH1N1 vaccine Isabelle Rouleau, PhD(c) Faculté de médecine, Université Laval
2.
3.
4.
5.
6.
Wheal and flare
7.
8.
9.
10.
11.
12.
Surveillance reports vs.
allergists N=91 22 (24.2) 59 (64.8) 7 (7.7) TOTAL 42 (46.2) 13 (59.1) 26 (44.1) 2 (4.8) Other 10 (11.0) 7 (70.0) 2 (3.4) 1 (14.3) ORS 14 (15.4) 0 (0.0) 13 (22.0) 0 (0.0) Allergy 22 (24.2) 2 (9.1) 15 (25.4) 4 (57.1) Anaphylaxis TOTAL N (col. %) ORS N (col. %) Allergy N (col. %) Anaphylaxis N (col. %) Reports ïš ïȘ Allergists
13.
Proportion of positive
skin tests 2 (5.6) 14 (15.4) 2 (5.6) 17 (18.7) To any vaccine component 1 (2.9) 7 (9.7) 2 (5.7) 7 (9.7) Reconstituted vaccine (day old) 2 (5.6) 9 (9.9) 2 (5.6) 10 (11.0) Reconstituted vaccine (same day) 1 (2.8) 6 (6.6) 1 (2.8) 11 (12.1) AS03 adjuvant 0 (0.0) 4 (4.4) 1 (2.8) 6 (6.6) pH1N1 antigen N (%) N (%) N (%) N (%) Controls Cases Controls Cases N (%) Positive (ID 5 mm) N (%) Positive (ID 3 mm)
14.
Proportion of positive
to prick tests among positives None 0/7 1 (2.9) 7 (9.7) Reconstituted vaccine (day old) None 2/9 (22%) 2 (5.6) 9 (9.9) Reconstituted vaccine (same day) None 2/6 (33%) 1 (2.8) 6 (6.6) AS03 adjuvant None 3/4 (75%) None 4 (4.4) pH1N1 antigen N (%) N (%) N (%) N (%) Controls Cases Controls Cases Positive to Prick test N (%) Positive (ID 5 mm)
15.
Positive skin tests
(prick or ID of 5 mm) by type of case 7(15.6) 1 (10.0) 1 (7.1) 5 (22.7) 2 (5.6) To any vaccine component 3 (7.7) 1 (12.5) 0 (0.0) 3 (15.8) 2 (5.7) Reconstituted vaccine (day old) 6 (13.3) 0 (0.0) 0 (0.0) 3 (13.6) 2 (5.6) Reconstituted vaccine (same day) 2 (4.4) 1 (10.0) 1 (7.1) 2 (9.1) 1 (2.8) AS03 adjuvant 2 (4.4) 0 (0.0) 1 (7.1) 1 (4.6) 0 (0.0) pH1N1 antigen N (%) N (%) N (%) N (%) N (%) Other ORS Allergy Anaphyl. Controls
16.
Positive skin tests
(ID 5mm), by component and type of reaction
17.
18.
19.
20.
21.
22.
23.
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