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Zen Body, Yogic Healing   William C. Bushell, PhD MIT and Tibet House (Director of East/West Studies) New York City Neil Soten Theise, MD Depts. Of Pathology and Medicine Beth Israel Medical Center – Albert Einstein College of Medicine New York City
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What kind of models?
for example, 2 models from Ancient Greece: Is the body made of…  indivisible subunits   or   an endlessly divisible fluid
 
 
 
 
Models of the body are  perspective/technique  dependent Look at it this way (cell membranes):  the body is made of cells Look at it that way (organelles):  the body is an endlessly divisible fluid
Models are  perspective/technique  dependent Look at it this way (cell membranes):  the body is made of cells Look at it that way (organelles):   the body is an endlessly divisible fluid Yet another way (the genome): …  overlapping spatial/temporal fields of molecular organization
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“ There’s no such thing as a central dogma into which everything will fit...any mechanism you can think of, you will find -- even if it is the most bizarre kind of thinking.  “ Anything...  “ So if the material tells you, ‘It may be this,’ allow that.  Don’t turn it aside and call it an exception, an aberration, a contaminant. “ So many good clues have been lost that way.“ “ A Feeling for the Organism” Evelyn Fox Keller, 1983 Nobel-laureate Barbara McClintock:
regeneration  aging longevity protection
regeneration
regeneration  tissue repair & restitution following cell loss or injury
regeneration  longevity
regeneration  aging longevity
regeneration  aging longevity protection
regeneration  aging longevity protection
GLOBAL/SYSTEMIC  interventions
Cognitive Behavioral Practices GLOBAL/SYSTEMIC  interventions
Cognitive ( mindfulness, visualization, analytical etc. ) Behavioral Practices GLOBAL/SYSTEMIC  interventions
Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC  interventions
Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC  interventions LOCAL  effects
Cognitive  ( e.g. mindfulness, contemplative ) Behavioral  ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC  interventions LOCAL  effects Site Specific, Tissue Regeneration
Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC  interventions LOCAL  effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Site Specific, Tissue Regeneration
Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC  interventions LOCAL  effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Humoral factors Nerve signaling Bioelectromagnetism Cell trafficking Site Specific, Tissue Regeneration
Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC  interventions LOCAL  effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Humoral factors Site Specific, Tissue Regeneration
Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC  interventions LOCAL  effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation e.g. Melatonin!! Site Specific, Tissue Regeneration
Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC  interventions LOCAL  effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation e.g. Melatonin!!
 
 
Abbasoglu O et al, 1995. The effect of the pineal gland  On liver regeneration in rats, J Hepatology 23: 578-81. Bellipanni G et al, 2005. Effects of melatonin in  perimenopausal and menopausal women: our personal  experience, Annals of the NY Academy of Sciences 1057: 393-402 Bubenik GA, 2002. Gastrointestinal melatonin: localization, function,  and clinical relevance, Digestive Disease Science 47: 2336-48. Castagnino HE et al, 2002. Cytoprotection by melatonin and growth hormone in early rat myocardial infarction as revealed by Feulgen DNA staining, Neurology Endocrinology Letters 23(5-6): 391-5. Conti et al, 2000.  Evidence for melatonin synthesis in mouse and human bone marrow cells. J Pineal Res. 2000 May;28(4):193-202. Csaba G, 1993. Presence in and effects of pineal indoleamines at very low level of phylogeny,  Experientia  49: 627-34. Danilova N et al, 2004. Melatonin stimulates cell  proliferation in zebrafish embryo and accelerates  its development,  FASEB J  18: 751-3. Dundar K et al, 2005. Protective effects of exogenously administered or endogenously produced  melatonin on hyperbaric oxygen-induced oxidative stress in the rat brain, Clinical & Experimental  Pharmacology and Physiology 32(11): 926-30. Erkanli K et al, 2005. Melatonin protects against  ischemia/reperfusion injury in skeletal muscle, J Pineal Research 39(3): 238-42. Escames G et al, 2006. Melatonin counteracts inducible  mitochondrial nitric oxide synthase-dependent mitochondrial  dysfunction in skeletal muscle of septic mice, J Pineal  Research 40(1): 71-8. Esrefoglu M et al, 2005. Potent therapeutic effect of melatonin on aging skin in pinealectomized rats, J Pineal Research 39(3): 231-7. Feng Z et al, 2006. Early melatonin supplementation alleviates  oxidative stress in a transgenic mouse model of Alzheimer’s disease,  Free Radicals in Biology & Medicine 40(1): 101-9.   Girotti L et al, 2003. Low  urinary 6-sulfatoxymelatonin levels in  patients with severe congestive heart  failure, Endocrine 22(3): 245-8. Karasek M, 2004. Melatonin, human aging, and age-related diseases, Experimental Gerontology 39(11-12): 1723-9. Kobayashi H, et al, 2005.  A role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors. FASEB J. 2005 Oct;19(12):1710-2. Lesnikov VA & Pierpaoli W, 1994. Pineal cross-transplantation (old-to-young and young-to-old) as evidence for an endogenous “aging clock” Annals of the NY Academy of Sciences 719: 456-60. Maestroni GJM et al, 1988. Pineal melatonin, its fundamental immunoregulatory role in aging and cancer, Annals of the NY Academy of Sciences 521: 140-8. Pierpaoli W, 1998. Neuroimmunomodulation of aging: a program in the pineal gland Annals of the NY Academy of Sciences 840: 491-7.  Pierpaoli & Maestroni GJM, 1987. Melatonin: a principal neuroimmunoregulatory and anti-stress hormone: its antiaging effects, Immunology Letters 16: 355-62. Sainz RM et al, 2003. Melatonin and cell death: differential  actions on normal and cancer cells, Cellular & Molecular Life Science 60: 1407-26. Slominski A, et al, 2005. On the role of melatonin in skin physiology and pathology.   Endocrine. 2005 Jul;27(2):137-48. MELATONIN
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[object Object],[object Object],[object Object],[object Object],[object Object]
 
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC  interventions LOCAL  effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Humoral factors Cell trafficking Site Specific, Tissue Regeneration
Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC  interventions LOCAL  effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Humoral factors Cell trafficking Nerve signaling Site Specific, Tissue Regeneration
Neil’s stuff #2
Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC  interventions LOCAL  effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Humoral factors Cell trafficking Nerve signaling Site Specific, Tissue Regeneration
Bill’s stuff #2
Bill’s stuff #2 NOT ONLY!
A  MIND – BODY CONNECTION nerves connect to liver stem cells
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC  interventions LOCAL  effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Humoral factors Nerve signaling Bioelectromagnetism Cell trafficking
Bioelectromagnetism Definitions!
Bioelectromagnetism NOT necessarily “ energy” or “chi” or or or or or…
Bioelectromagnetism Electron or ionic flux
Bioelectromagnetism Electron or ionic flux Nerve conduction Tissue flux Molecular level ( DNA )
Bioelectromagnetism Electron or ionic flux Nerve conduction Tissue flux Molecular level ( DNA )
 
 
 
Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC  interventions LOCAL  effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Humoral factors Nerve signaling Bioelectromagnetism Cell trafficking Site Specific, Tissue Regeneration
 
Nerves Cell Trafficking Humoral factors Bioelectomagnetic
Nerves Cell Trafficking Humoral factors Bioelectomagnetic Yoga Asanas Chi Kung Acupuncture Pranayama Meditation
Macroscopic body Microscopic body Nanoscopic body Quantum body
Macroscopic body Microscopic body Nanoscopic body Quantum body e.g. physical therapy surgery e.g.  cell therapies e.g. molecular medicine antibiotics e.g.  electromagnetics
Macroscopic body Microscopic body Nanoscopic body Quantum body e.g. yoga tai chi e.g. acupuncture? e.g. traditional remedies e.g. energy healing? meditation?
Macroscopic body Microscopic body Nanoscopic body Quantum body Coarse Body ? Energy Body ? Subtle Body ? Indo-Tibetan Medicine/Physiology
Macroscopic body Microscopic body Nanoscopic body Quantum body Coarse Body ? Energy Body ? Subtle Body ? Indo-Tibetan Medicine/Physiology
From the global to the local: Pathways for the transduction of Indo-Sino-Tibetan cognitive behavioral practices  into site specific, tissue regenerative effects. William C Bushell & Neil D. Theise Beyond cell doctrine: Complexity thery informs alternate models of the bdy For cross cultural dialogue Neil D. Theise www.neiltheise.com
 

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Theise Upaya 2 2008

  • 1. Zen Body, Yogic Healing William C. Bushell, PhD MIT and Tibet House (Director of East/West Studies) New York City Neil Soten Theise, MD Depts. Of Pathology and Medicine Beth Israel Medical Center – Albert Einstein College of Medicine New York City
  • 2. Put group portrait from menla conference HERE
  • 3. What kind of models?
  • 4. for example, 2 models from Ancient Greece: Is the body made of… indivisible subunits or an endlessly divisible fluid
  • 5.  
  • 6.  
  • 7.  
  • 8.  
  • 9. Models of the body are perspective/technique dependent Look at it this way (cell membranes): the body is made of cells Look at it that way (organelles): the body is an endlessly divisible fluid
  • 10. Models are perspective/technique dependent Look at it this way (cell membranes): the body is made of cells Look at it that way (organelles): the body is an endlessly divisible fluid Yet another way (the genome): … overlapping spatial/temporal fields of molecular organization
  • 11. Put group portrait from menla conference HERE
  • 12. “ There’s no such thing as a central dogma into which everything will fit...any mechanism you can think of, you will find -- even if it is the most bizarre kind of thinking. “ Anything... “ So if the material tells you, ‘It may be this,’ allow that. Don’t turn it aside and call it an exception, an aberration, a contaminant. “ So many good clues have been lost that way.“ “ A Feeling for the Organism” Evelyn Fox Keller, 1983 Nobel-laureate Barbara McClintock:
  • 13. regeneration aging longevity protection
  • 15. regeneration tissue repair & restitution following cell loss or injury
  • 17. regeneration aging longevity
  • 18. regeneration aging longevity protection
  • 19. regeneration aging longevity protection
  • 21. Cognitive Behavioral Practices GLOBAL/SYSTEMIC interventions
  • 22. Cognitive ( mindfulness, visualization, analytical etc. ) Behavioral Practices GLOBAL/SYSTEMIC interventions
  • 23. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions
  • 24. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects
  • 25. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects Site Specific, Tissue Regeneration
  • 26. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Site Specific, Tissue Regeneration
  • 27. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Humoral factors Nerve signaling Bioelectromagnetism Cell trafficking Site Specific, Tissue Regeneration
  • 28. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Humoral factors Site Specific, Tissue Regeneration
  • 29. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation e.g. Melatonin!! Site Specific, Tissue Regeneration
  • 30. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation e.g. Melatonin!!
  • 31.  
  • 32.  
  • 33. Abbasoglu O et al, 1995. The effect of the pineal gland On liver regeneration in rats, J Hepatology 23: 578-81. Bellipanni G et al, 2005. Effects of melatonin in perimenopausal and menopausal women: our personal experience, Annals of the NY Academy of Sciences 1057: 393-402 Bubenik GA, 2002. Gastrointestinal melatonin: localization, function, and clinical relevance, Digestive Disease Science 47: 2336-48. Castagnino HE et al, 2002. Cytoprotection by melatonin and growth hormone in early rat myocardial infarction as revealed by Feulgen DNA staining, Neurology Endocrinology Letters 23(5-6): 391-5. Conti et al, 2000. Evidence for melatonin synthesis in mouse and human bone marrow cells. J Pineal Res. 2000 May;28(4):193-202. Csaba G, 1993. Presence in and effects of pineal indoleamines at very low level of phylogeny, Experientia 49: 627-34. Danilova N et al, 2004. Melatonin stimulates cell proliferation in zebrafish embryo and accelerates its development, FASEB J 18: 751-3. Dundar K et al, 2005. Protective effects of exogenously administered or endogenously produced melatonin on hyperbaric oxygen-induced oxidative stress in the rat brain, Clinical & Experimental Pharmacology and Physiology 32(11): 926-30. Erkanli K et al, 2005. Melatonin protects against ischemia/reperfusion injury in skeletal muscle, J Pineal Research 39(3): 238-42. Escames G et al, 2006. Melatonin counteracts inducible mitochondrial nitric oxide synthase-dependent mitochondrial dysfunction in skeletal muscle of septic mice, J Pineal Research 40(1): 71-8. Esrefoglu M et al, 2005. Potent therapeutic effect of melatonin on aging skin in pinealectomized rats, J Pineal Research 39(3): 231-7. Feng Z et al, 2006. Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer’s disease, Free Radicals in Biology & Medicine 40(1): 101-9. Girotti L et al, 2003. Low urinary 6-sulfatoxymelatonin levels in patients with severe congestive heart failure, Endocrine 22(3): 245-8. Karasek M, 2004. Melatonin, human aging, and age-related diseases, Experimental Gerontology 39(11-12): 1723-9. Kobayashi H, et al, 2005. A role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors. FASEB J. 2005 Oct;19(12):1710-2. Lesnikov VA & Pierpaoli W, 1994. Pineal cross-transplantation (old-to-young and young-to-old) as evidence for an endogenous “aging clock” Annals of the NY Academy of Sciences 719: 456-60. Maestroni GJM et al, 1988. Pineal melatonin, its fundamental immunoregulatory role in aging and cancer, Annals of the NY Academy of Sciences 521: 140-8. Pierpaoli W, 1998. Neuroimmunomodulation of aging: a program in the pineal gland Annals of the NY Academy of Sciences 840: 491-7. Pierpaoli & Maestroni GJM, 1987. Melatonin: a principal neuroimmunoregulatory and anti-stress hormone: its antiaging effects, Immunology Letters 16: 355-62. Sainz RM et al, 2003. Melatonin and cell death: differential actions on normal and cancer cells, Cellular & Molecular Life Science 60: 1407-26. Slominski A, et al, 2005. On the role of melatonin in skin physiology and pathology. Endocrine. 2005 Jul;27(2):137-48. MELATONIN
  • 34.
  • 35.
  • 36.
  • 37.  
  • 38.  
  • 39.
  • 40.  
  • 41.
  • 42. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Humoral factors Cell trafficking Site Specific, Tissue Regeneration
  • 43. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Humoral factors Cell trafficking Nerve signaling Site Specific, Tissue Regeneration
  • 45. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Humoral factors Cell trafficking Nerve signaling Site Specific, Tissue Regeneration
  • 47. Bill’s stuff #2 NOT ONLY!
  • 48. A MIND – BODY CONNECTION nerves connect to liver stem cells
  • 49.
  • 50.
  • 51.
  • 52.
  • 53. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Humoral factors Nerve signaling Bioelectromagnetism Cell trafficking
  • 55. Bioelectromagnetism NOT necessarily “ energy” or “chi” or or or or or…
  • 57. Bioelectromagnetism Electron or ionic flux Nerve conduction Tissue flux Molecular level ( DNA )
  • 58. Bioelectromagnetism Electron or ionic flux Nerve conduction Tissue flux Molecular level ( DNA )
  • 59.  
  • 60.  
  • 61.  
  • 62. Cognitive ( e.g. mindfulness, contemplative ) Behavioral ( e.g. prostrations, yoga asanas, pranayama, caloric restriction ) Practices GLOBAL/SYSTEMIC interventions LOCAL effects e.g. Stabilization of stem cell niche and stem cell integrity Proliferation and organization of repopulating cells Inhibition of scar formation Humoral factors Nerve signaling Bioelectromagnetism Cell trafficking Site Specific, Tissue Regeneration
  • 63.  
  • 64. Nerves Cell Trafficking Humoral factors Bioelectomagnetic
  • 65. Nerves Cell Trafficking Humoral factors Bioelectomagnetic Yoga Asanas Chi Kung Acupuncture Pranayama Meditation
  • 66. Macroscopic body Microscopic body Nanoscopic body Quantum body
  • 67. Macroscopic body Microscopic body Nanoscopic body Quantum body e.g. physical therapy surgery e.g. cell therapies e.g. molecular medicine antibiotics e.g. electromagnetics
  • 68. Macroscopic body Microscopic body Nanoscopic body Quantum body e.g. yoga tai chi e.g. acupuncture? e.g. traditional remedies e.g. energy healing? meditation?
  • 69. Macroscopic body Microscopic body Nanoscopic body Quantum body Coarse Body ? Energy Body ? Subtle Body ? Indo-Tibetan Medicine/Physiology
  • 70. Macroscopic body Microscopic body Nanoscopic body Quantum body Coarse Body ? Energy Body ? Subtle Body ? Indo-Tibetan Medicine/Physiology
  • 71. From the global to the local: Pathways for the transduction of Indo-Sino-Tibetan cognitive behavioral practices into site specific, tissue regenerative effects. William C Bushell & Neil D. Theise Beyond cell doctrine: Complexity thery informs alternate models of the bdy For cross cultural dialogue Neil D. Theise www.neiltheise.com
  • 72.