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Hantaviruses are primarily rodent-borne pathogens, which have received considerable attention in recent decades due to their high mortality rate. In order to find the causes of emergence of hantavirus-associated diseases anthropogenic changes are a priority. These include urbanization, deforestation, noise pollution, light pollution and electromagnetic fields, all of which have been shown to profoundly affect rodent physiology and immunology. These transformations act as chronic stressors to rodents and cause elevated concentrations of glucocorticoids, which are a major class of immunosuppressive hormone. Glucocorticoids are responsible for altering the immune tolerance of rodents, thereby rendering them susceptible to infection. A perspective of these events affords an insight into the extent to which anthropogenic stressors are responsible for the emergence and persistence of hantaviruses in rodents. Glucocorticoids induce T regulatory (Treg) lymphocytes to reduce inflammatory and antiviral responses and to activate regulatory responses, principally through production of the cytokines interleukin-10 and transforming growth factor-β to support viral persistence. It is concluded that in order to develop a low-cost intervention strategy consideration should be given to a systemic approach to therapy of hantavirus infection. This would target both a reduction of anthropogenic stressors and a greater understanding of host-parasite interactions.

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After hours of googling “URL redirection with Apache”, I found lots of resources but it is hard to understand and too much complicated information. To make people clearly understand, this presentation provides clear explanation on the difficult things and good examples. It will give you a basic knowledge that you should know before digging deep into the details such as “http status code” and “rewrite rule”. There are a few examples to guide you how to do. I really hope it will be useful not only for the beginners, but also for the more advanced developers. Please let me know if you have any comments or suggestions.

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Study on Suppressive Effect of Anthropogenic Stress and Regulation of Hantavi...

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