13. Acitretin 노출
Abstract
We assessed the pregnancy outcome of nine women inadvertently transfused with acitretin-
contaminated blood products in South Korea. A total of 18 women matched to cases by age,
gravidity, and singleton- or twin-pregnancy, and who were transfused with blood products not
contaminated with acitretin, was also recruited. There were nine babies born in the case group.
No differences (p > 0.05) were observed between cases and controls in the gestational age at
delivery (38.3 +/- 1.6 weeks vs 37.8 +/- 2.2 weeks), birth weight (3,146 +/- 874 g vs 3,106 +/-
568 g), rate of pre-term deliveries (22.2% vs 11.1%) and rate of low birth weight (<2,500 g)
(33.3% vs 16.7%). There was no case of malformation or neurological abnormalities born in
either group. In conclusion, inadvertent exposure to acitretin-contaminated blood products
was not associated with adverse pregnancy outcomes, probably because of the removal of
acitretin and etretinate during the manufacturing process of blood products.
15. 베이비플랜의 정의
“ 예방과 관리를 통해 여성의 건강
또는 임신결과에 영향을 미치는
생의학적, 행동적, 사회적 위험을
찾아 개선하는 일련의 중재”
- CDC 2006 -
16. 베이비플랜을 위해 클리닉 방문한 이유
Paternal chronic disease
Genetic disease N=686
Previous abnormal baby 2004.10~2009.12
Bad OB history No specific reason
Previous miscarriage
핚국마더세이프젂문상담센터 2010
24. 당뇨병
0.5% (3/572)
핚국마더세이프젂문상담센터 2010
9
Malformations
Percent of
8 8.8
In diabetic women
7
6 Counseling(n=601)
5 5.6 No counseling(n=612)
Counseling
No counseling
4
All women(n=1855)
All women
3
2
1 (Lancet 1992)
1.0
0
1
31. 0.5% (3/572)
핚국마더세이프젂문상담센터 2010
간질(Epilepsy)
Drug Abnormalities Affected Catego.
1-2% with monotherapy
Valproate NTD, Clefts, Skeletal abnormalities, developmental delay
9-12% with polytherapy
D
Fetal hydantoin sd: craniofacial anomalies, finger nail
hypoplasia,
Phenytoin Growth deficiency, cardiac defects, clefts, developmental
5-11% D
delay
Carbamazepine Fetal hydantoin sd, spina bifida 1-2% D
Phenobarbital Clefts, cardiac anomalies, Urinary tract malformations 10-20% D
Inhibits dihydrofolate reductase, lowering fetal folate levels, 4-fold with monotherapy
Lamotrigine Registry data suggest increased risk for clefts 10-fold with polytherapy
C
Topiramate Registry data suggest increased risk for clefts 2% C
Theoretical-skeletal abnormalities and impaired growth in a
Too few cases reported to
Levetriacetam nimals ant doses similar to or greater than human therapeu
assess risk
C
tic doses
