When Worlds Collide discusses the momentous events of 1492, when Columbus arrived in the Americas, forever altering life in Europe by introducing new commodities and wealth from the Americas. It describes the conventional narrative that views Native Americans as primitive peoples easily conquered by a superior European culture. It also discusses Spain's choice between religious unity or wealth from the Americas, and how a son of an Incan princess and Spanish conquistador became the first American-born author, honoring his indigenous heritage.