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1. Chemical Process Industry - 2
Arham Veerayatan Institute
of Engineering, Technology &
Research

2. Presentation On
Production of
Aspirin
Name : Bhatt Milan L.
Branch : Chemical 2nd Year
En. No. : 140920105002
Roll No. : 03

3. INDEX
1. About Aspirin
2. Production Of Salicylic Acid
3. Production Of Aspirin
4. Uses Of Aspirin
5. Side Effects

4. What is
Aspirin
• its IUPAC name is: 2- Acetyloxybenzoic Acid and
It is also commonly known by the name Acetyl
Salicylic Acid.
• Aspirin is in group of drugs called salicylates

5. Aspirin
• Structural
Formula of
aspirin is :
• Its molecular formula is: C9H8O4
• molecular weight is: 180.157 g/mole

6. Raw Materials
• Phenol
• Caustic Soda
• Carbon Dioxide.
For Salicylic Acid :

7. Chemical Reaction
2 2NaOH 2H2O
OH
ONa
ONa
CO2Na
H2SO4+
+ CO2
Sodium Phenolate
ONa
OH
OH
CO2Na
ONa
Sodium Salicylate
+ Na2SO4
CO2H
+
+ +
Salicylic Acid
2
100* C
130* C

8. Phenol
Mixer
Autoclave
130* C
Caustic Soda
Precipitation
Carbon Dioxide
100* C
Sulphuric acid
Packing
Salicylic Acid
Production Of Salicylic Acid
Phenol Recovery
Decoloriser

9. Raw Materials
• Salicylic Acid
• Toluene
• Acetic Anhydride
Chemical Reaction
OH
CO2H
Salicylic Acid
O2CCH3
CO2H
Aspirin
+ H2O
(CH3CO)2O
For Aspirin :
90* C

10. Reactor
90* C
Cooling Tank
Packing
Salicylic Acid
Acetic Anhydride
In toluene
Filter
Aspirin
Production Of Aspirin

11. Uses Of Aspirin
• It is used to treat pain and fever.
• Aspirin is also used long-term, at low doses, to
help prevent heart attacks, strokes, and blood
clot formation in people at high risk of developing
blood clots.
• Aspirin may be effective at preventing certain types
of cancer, particularly colorectal cancer.
• Over-the-counter pain relief, especially for
headaches.

12. SIDE Effects :
• Risk of increase in gastrointestinal bleeding.
• It inhibits the ability of kidney to excrete uric acid
and exacerbate these conditions.
• Large dosages results in tinnitus (ringing in ears).
• May result in fatty liver and acute encephalopathy.
• May cause swelling of skin tissues.
• It increases the risk of cerebral microbleed.